3094603
Questão 1
Questão
What is the most common cancer in males?
Responda
-
Non Melanoma Skin Caner
-
Prostrate cancer
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Lung cancer
-
Colorectal
Questão 2
Questão
What is the most common cancer in females?
Responda
-
Breast cancer
-
Non Melanoma Skin Cancer
-
Lung cancer
-
Colorectal cancer
Questão 3
Questão
How do Tobacco smoke and coal tar form cancer?
Responda
-
Forming aldehyde adducts
-
Forming DNA adducts
Questão 4
Questão
Exposure to what substances increases the liver cancer incidence?
Responda
-
Aflatoxin B1 and Hepatitits B
-
alcohol and tobacco
Questão 5
Questão
Protooncogene inheritance is classified as
Responda
-
Loss of function
-
Gain of function
-
Both
-
None of the above
Questão 6
Questão
Tumor suppressor gene inheritance is classified as?
Responda
-
Loss of function
-
Gain of function
-
Both
-
None of the above
Questão 7
Questão
In Familial cancer syndrome what is the gene that is mutated?
Responda
-
RET
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MET(HGFR)
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BCR
-
ABL
Questão 8
Questão
In Hereditary renal papillary carcinoma what is the gene that is mutated?
Responda
-
MET (HGFR)
-
RET
-
ABL
-
BCR
Questão 9
Questão
What is the translocation in follicular lymphoma
Responda
-
14:18
-
15:17
-
9:22
-
11:22
Questão 10
Questão
CML translocation is seen between what chromosomes?
Responda
-
9:22
-
15:17
-
11:22
-
14:18
Questão 11
Questão
What translocation is seen in Promyelocytic leukemia?
Responda
-
15:17
-
9:22
-
11:22
-
14:18
Questão 12
Questão
Translocation in Ewing's Sarcoma?
Responda
-
11:22
-
14:18
-
15:17
-
9:22
Questão 13
Questão
How does translocation cause cancer?
Responda
-
The novel product promotes proliferates like an oncogene
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It makes a transcription factor that promotes proliferation
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It makes a novel factor that inhibits apoptosis
-
None of the above
Questão 14
Questão
N-MYC is amplified in what tumor?
Responda
-
Neuroblastoma
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Pheochromocytoma
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Wilms tumor
Questão 15
Questão
In Knudson's 2 hit model what are the mechanisms for the second hit?
Responda
-
Loss of heterozygosity
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Deletion
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recombination
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non-dysjunction
-
All of the above
Questão 16
Questão
Which of the following is not inherited by Autosomal Dominance?
Responda
-
Retinoblasotma
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Li-Fraumeni Syndrome
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Hereditary Breast cancer
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Neurofibromatosis 1
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FAP / HNPCC
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None of the above
Questão 17
Questão
What are the mutations in FAP?
Responda
-
APC
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BCR
-
ABL
Questão 18
Questão
What are the mutations in HNPCC?
Responda
-
MLH 1 and 3
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MSH 2 and 6
-
PMS 1 and 2
-
All of the above
Questão 19
Questão
Wnt binds to Frizzled and activates dishevelled which in turn inhibits APC/Axin/GSK-3Beta
Responda
- True
- False
Questão 20
Questão
Beta Catenin is not phosphorylated so not destroyed so it accumulates and promotes proliferation
Responda
- True
- False
Questão 21
Questão
Microsatellite instability/ replication error positive is seen in HNPCC - true or false
Responda
- True
- False
Questão 22
Questão
What are the mutations that are seen in sporadic cancer?
Responda
-
PTEN
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TGFBR2
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SMAD4
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WT1
-
All of the above
Questão 23
Questão
In Xeroderma Pigmentosum the most common nucleotide repair mechanism is excision endonuclease deficiency - true or false?
Responda
- True
- False
Questão 24
Questão
In Ataxia Telegectasia (ATM) mutation of what gene promotes proliferation?
Responda
-
p53
-
RB
-
myc
-
none of the above
Questão 25
Questão
Bloom syndrome - DNA helicase deficiency - true or flase
Responda
- True
- False
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