3095561
Questão 1
Questão
Loss of WT-1 gene results in what cancer?
Responda
-
Neuroblastoma
-
Wilms tumor
Questão 2
Questão
All of the following are Autosomal recessive cancer predisposition disorders except?
Responda
-
Xeroderma Pigmentosum (XP)
-
Bloom syndrome
-
Fanconi anemia
-
Ataxia Telengiectasia
-
Breast cancer associated with BRCA2
Questão 3
Questão
All of the following are features of fanconi anemia except
Responda
-
Pancytopenia (bone marrow failure)
-
Risk of AML
-
Upper limb skeletal abnormalities
-
DNA repair defect
-
none of the above
Questão 4
Questão
Glioblastoma multiforme is due to 100x expression of an miRNA true or false?
Responda
- True
- False
Questão 5
Questão
Translocation in Burkitt's lymphoma
Responda
-
8:14
-
9:22
-
11:22
-
none of the above
Questão 6
Questão
All of the following are true statements except
Responda
-
Kaposis sarcoma caused by HHV-8
-
Non-Hodgkin lymphoma - EBV
-
Cervical cancer - HPV
-
T-Cell leukemia - HTLV-I retrovirus
-
CML - HPV
Questão 7
Questão
HPV oncogenes E6 & E7 act by?
Responda
-
inactivating p53 thereby activating cell proliferation
-
activating P21 Transciption
Questão 8
Questão
In which cells telomeres are renewed (by activation of telomerase)?
Responda
-
Germ cells
-
cancer cells
-
all of the above
-
None of the above
Questão 9
Questão
Replicative senescence is due to the absence of telomerase - true or false
Responda
- True
- False
Questão 10
Questão
TERC : reverse transcriptase and TERT : RNA template true or false
Responda
- True
- False
Questão 11
Questão
Upregulation of what gene upregulates telomerase
Responda
-
MYC
-
ABL
-
BCR
-
RET
Questão 12
Questão
Telomerase reactivation in cancer is the initiating event true or false
Responda
- True
- False
Questão 13
Questão
Telomerase reactivation in cancer is an important step in cancer progression true or false
Responda
- True
- False
Questão 14
Questão
Which of the following receptors belong to RTK family (receptor tyrosine kinases)
Responda
-
GFR
-
Insulin receptor
-
both
-
none of the above
Questão 15
Questão
Activated RTKs phosphorylate what effector proteins?
Responda
-
PLC
-
PI3K
-
both PLC PI3K
-
Adenylate cyclase
Questão 16
Questão
RTK activation -> reveals docking site for adapter protein GRB2 -> binds to SOS (RAS GEF) --> activates RAS -> activates MAPK --> activates TFs ( FOS, JUN, MYC) true or false
Responda
- True
- False
Questão 17
Questão
Her2/EGFR2 genes are amplified in 30% breast cancers true or false
Responda
- True
- False
Questão 18
Questão
RAS-Gap gene codes for neurofibromin (NF1) true or false
Responda
- True
- False
Questão 19
Questão
Estrogen receptor = Transcription factor which binds to estrogen response element enhancing transcription of cyclin D true or false
Responda
- True
- False
Questão 20
Questão
Tamoxifen is an estrogen receptor antagonist true or false
Responda
- True
- False
Questão 21
Questão
Prostate cancer occurs in the transition zone and BPH occurs primarily in the peripheral zone true or false
Responda
- True
- False
Questão 22
Questão
Flutamide and bicalutamide are androgen receptor antagonists true or false
Responda
- True
- False
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