3097502
Questão 1
Questão
All of the following are the subphases of interphase except?
Responda
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G1 phase
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S Phase
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G2 phase
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M phase
Questão 2
Questão
A restriction point is when
Responda
-
a cell is irreversibly committed to cell cycle progression or apoptosis
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a cell is reversibly committed to cell cycle progression or apoptosis
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None of the above
Questão 3
Questão
Cell cycle is regulated by Cyclin-dependent kinases true or false
Responda
- True
- False
Questão 4
Questão
All of the following about Cdks are true except
Responda
-
Cdk levels are usually constant
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Cdks are inactive in the absence of Cyclin
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Cdks are activated by binding to Cyclins
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Cdks phosphorylate cell regulatory proteins
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Cdk levels vary with cell cycle
Questão 5
Questão
All of the following are true about Cyclin D except?
Responda
-
It is made at the start of G1 by growth factor mediated gene transcription
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Cyclin D binds and activates CDK4,6
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Cyclin D is degraded at the end of G1
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Cdk 4/6 is active in the absence of cyclin D
Questão 6
Questão
all of the following are true except?
Responda
-
Cyclin D-CDK 4/6 will phosphorylate Rb
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Activated Rb will release E2F
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E2F will cause Cyclin E synthesis
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Cyclin E binds and activates CDK-2
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Dephosphylated Rb is active
Questão 7
Questão
DNA damage-induced pathways target degradation of Cyclin D first and then Cyclin E which stops cell cycle progression true or false
Responda
- True
- False
Questão 8
Questão
hypophosphorylated Rb prevents E2F activity thereby preventing cell cycle progression true or false
Responda
- True
- False
Questão 9
Questão
All of the following about negative regulators of cell cycle are correct except?
Responda
-
INK4 (inhibitors of kinase4) family bind and inhibit only cyclin D-Cdk4/6 complexes at restriction point p15,p16
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CIP (Cdk inhibitory protein) family bind and inhibit all cyclin-Cdk complexes at the restriction point p21
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p16 normally inhibits Cdk4
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in the absence of p16 Cdk 4 is active and phosphorylate Rb wichin in turn activates E2F
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p16 normally activates Cdk4
Questão 10
Questão
Normally p53 levels are kept low by MDM2 true or false
Responda
- True
- False
Questão 11
Questão
All of the following about p53 are correct except?
Responda
-
p53 expressed at very high levels normally
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DNA damage leads to phosphorylation of p53 stabilizing it and increasing its concentration
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p53 acts as transcriptional activator increasing synthesis of Cdk inhibitor p21
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p21 inhibits Cdk/ cyclin G1 and S complexes --> cell cycle arrest in G1
Questão 12
Questão
Abnormally high level of Myc causes systhesis of ARF which binds and inhibits MDm2 causing increase p53 which causes cell cycle arrest true or false
Responda
- True
- False
Questão 13
Questão
Cell cycle progression at check point 2 (G2-M) is regulated by phosphorylation of Cdk1-Cyclin B complex true or false
Responda
- True
- False
Questão 14
Questão
All of the following are inducers of apoptosis except?
Responda
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Virus infected cells
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DNA damage
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Growth factor withdrawal
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Ionising radiation
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Calcium eflux
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tumor necrosis factor
Questão 15
Questão
Following is the sequence of Extrinsic apoptotic pathway except?
Responda
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Extrinsic apoptotic pathway is initiated by binding of death-inducing ligand to a death receptor (Cys-rich repeat in the extracellular domain)
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Death receptor are FasR and TNF receptor which are integral membrane proteins with their receptor domains exposed at the surface of te cell
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binding of the death activator (FasL and TNF-alpha) leads to activation of caspase -9
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which in turn initiates a cascade of caspase activation leading to cell death
Questão 16
Questão
All of the following are pro-apoptotic genes except
Responda
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Bcl-2
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Bax
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Diva
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Bad
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Bik, Bim
Questão 17
Questão
Bid links he 2 apoptotic pathways (extrinsic and intrinsic) true or false
Responda
- True
- False
Questão 18
Questão
Both pathways converge on the activation of Caspase-3,6,7 true or false
Responda
- True
- False
Questão 19
Questão
All of the following stimulate angiogenesis except
Responda
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VEGF
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FGF
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EGF
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Angiotropin
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Angiogenin
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Angiostatin
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TIP Statin anywhere stops (from static)
Questão 20
Questão
Hypoxia --> HIF which induces VEGF which binds to RTK and dramatically decreases metastatic potential - true or false
Responda
- True
- False
Questão 21
Questão
VEGF is secreted by all of the following except?
Responda
-
Healthy tissues needing more blood
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Hypoxic tissues
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Tumors
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Highly oxygenated tissues
Questão 22
Questão
All the following statements are true except?
Responda
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Bevacizumab blocks VEGF
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Sunitinib, Sorafenib block VEGFR
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Angiostatin inhibits plasminogen fragment
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Endostatin inhibits endothelial cell BM collagen XVIII fragment
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Tumstatin inhibits collagen IV fragment
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Thrombospondin inhibits Fas-R expression
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Cefuximab inhibits EGFR
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Herceptin (Trastuzumab) inhibits HER2
Questão 23
Questão
All of the following are true except?
Responda
-
Serine proteases (uPA, tPA, plasminogen) activate MMPs
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MMPs digest ECM by digesting type IV collagenase
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Plasminogen promotes clotthing
Questão 24
Questão
Tumor motility factors AMF,HGF, EGF all promote motility via Rho GTPases - true or false
Responda
- True
- False
Questão 25
Questão
Tumor arrest in a specific tissue is by chance only true or false
Responda
- True
- False
Questão 26
Questão
Breast cancer cell express CXCR4, which bind to ligand CXCL12 in the lung,liver and bone - true or false
Responda
- True
- False
Questão 27
Questão
Major limiting step of the metastasis is the hospitability of the host microenvironment true or false
Responda
- True
- False
Questão 28
Questão
The following are matched properly except
Responda
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Topisomerase II inhibitors: Doxorubicin and Daunorubicin
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Vinca alkaloids (Vinblastine and Vincristine) enhances polymerization of microtubles
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Taxol(Paclitaxel) binds and stabilizes microtubles
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Borezomib (Velcade) blocks proteasome activity which prevents IkB degradation build up of Bax and Bak which leads to apoptosis
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Tarceva and Iressa inhibit EGFR TKi
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Imatinib?Gleevec inhibit TKi in CML
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