3190698
Questão 1
Questão
All of the following are part of Fab region of Ig except?
Responda
-
VH
-
VL
-
CH 2
-
CL
Questão 2
Questão
VH and VL determines the idiotype and CH2 and CH3 determine the isotype of Ig
Responda
- True
- False
Questão 3
Questão
Antigen Binding site
Responda
-
Specificity is determined by hypervariable regions within the variable domain
-
Each variable region has 3 hypervariable regions called complementary determining regions (CDRs)
-
An antigen binding site is composed of 3 light chain CDRs and 3 heavy chain CDRs
-
All of the above are true
-
None of the above
Questão 4
Questão
Ig Determinants
Responda
-
Isotypic : constant domain, present in all individuals of a species
-
Allotypic: constant domain; different alleles within a species
-
Idotypic: antigen binding site
-
all of the above are true
-
1&2 are true
Questão 5
Questão
Antibodies interact with molecules by the Fc receptors (constant region)
Responda
- True
- False
Questão 6
Questão
Regarding different classes of Ig a
Responda
-
IgG - Monomer - circulating - Most abundant in serum - crosses transplacentally via brambell receptor
-
IgM - Pentamer - Surface of B cells or circulating - Ag receptor on B cell - First class of Ab released by B cells during primary response
-
IgA - Monomer - Surface of B cells - Important for B cell activation - Co-expressed with IgM on B cells due to differential RNA splicing
-
IgD - circulating monomer, secreted dimer - circulating in plasma or secreted in saliva ,tears, milk etc - protects mucosal surfaces
-
IgE - Monomer - circulating or cell bound - found in mast cells and basophils - High affinity IgE receptors binds in the absence of Ag
-
All are correct
-
1,2,5 are correct
-
3,4 are correct
-
All are wrong
Questão 7
Questão
Regarding Pro-B cell all are true except?
Responda
-
No Ig is expressed
-
Recombination Signal Sequences (RSS) & 12/23 rule regulate arrangement & ensure that proper joining occurs: D-J --> V-DJ
-
RAG1/RAG2 recognised and binds to Il-7R
-
Palindromic nucleotide addition at hairpin loop formation by DNA polymerase
-
Non-template nucleotide addition at hairpin loop formation by TdT
Questão 8
Questão
Regarding Pre-B cell
Responda
-
IgM expressed
-
Allelic Exclusion: RAG1/RAG2 is repressed to stop VDJ rearrangement of H locus
-
RAG1/RAG2 is re-expressed for VJ rearrangement - Somatic Recombination - of each daughter cell's L chain
-
Kappa light chain recombines 1st
-
all of the above are correct
Questão 9
Questão
Immature B cell - all are true except
Responda
-
IgG expressed
-
Negative Selection for Tolerance - Immature B cell with no self reaction will continue on to maturity and leave the bone marrow
-
Light chain rearranges for a chance to make BCR with new specificity
-
Immature B cell binds multivalent self-antigen and fails receptor editing --> Clonal deletion (apoptosis)
-
mmature B cells bind soluble self-antigen --> Clonal anergy
Questão 10
Questão
Mature B cell express IgM + IgD due to differential RNA splicing
Responda
- True
- False
Questão 11
Questão
CD21 co-receptor binds Fc of Ig (ITIM) - positive co-receptor --> activation
FcyR binds to C3d - negative co-receptor --> no activation
Responda
- True
- False
Questão 12
Questão
Following is the sequence of events 1st T_B cell interaction - all of the following are true except?
Responda
-
Antigen activated B cell (APC) migrates toward T-B boundary and present antigen by MHC II to CD4+ Helper T cell
-
CD40 activates T Helper to express CD40-L and cytokines
-
CD40-CD40-L bind and T Helper releases cytokines toward B cell
-
Mutated CD40-L results in X-Linked agammaglobulinemia
-
Proliferation of activated B cell to form germinal centers (Clonal expansion)
-
AID (Activation Induced Deaminase) inserts point mutations in the variable regions of BCR for diversification of BCR
Questão 13
Questão
All of the following regarding 2nd T-B cell interaction are true except?
Responda
-
Class/Isotypic Switching : The constant region of the heavy chain undergoes change of Ig Isotype but the selected variable region stays the same maintaining antigenic specificity and affinity
-
Isotype is determined by cytokines released from Helper T cell
-
Enables the same assembled Vh exon to be associated with different CH genes in the course of an immune response thus increasing the divrsity of Ig function
-
Il-4 secreting T cell stimulate Plasma cell production and Il-10 secreting T cell stimulate memory B cell production
Questão 14
Questão
Thymus independent response the antigens are polysaccharides and the antibody made is always IgM because there is no class switching, no affinity maturation and no memory cell formation
Responda
- True
- False
Questão 15
Questão
MHC Class I is expressed on the surface of all nucleated cells including RBC
Responda
- True
- False
Questão 16
Questão
Endogenous pathway MHC I and Exogenous pathway MHC II
Responda
- True
- False
Questão 17
Questão
Antign processing is proteolytic deradation of proteins into peptides of a suitable size for binding to MHC
Antigen Presentation - actual display of the processed peptide bound to MHC molecules on the surgace of an APC or target cell
Responda
- True
- False
Questão 18
Questão
T cell recognize non linear and conformational determinants
Responda
- True
- False
Questão 19
Questão
Dendritic cells are exception to the rule - Cross presentation allows exogenous proteins to be presented on MHC I and endogenous proteins to be presented by MHC II by autophagy
Responda
- True
- False
Questão 20
Questão
Viral proteins interfere with MHC I
Responda
-
Inhibit peptide transport
-
Inhibit peptide loading
-
Cause MHC I degradation
-
all of the above
-
none of the above
Questão 21
Questão
Intracellular bacteria evade MHC II by
Responda
-
Escape endosomes
-
Neutralize endosome acidification
-
Block fusion with lysosomes
-
Sequesters MHC II molecules after vesicle fusion
-
All of the above
Quer criar seus próprios Quizzes gratuitos com a GoConqr? Saiba mais.