Questão 1
Questão
Select all that apply. Which of the following are β-lactamase penicillins?
Responda
-
Ampicillin
-
Ticarcillin
-
Methicillin
-
Piperacillin
-
Nafcillin
-
Amoxicillin
Questão 2
Questão
What does PBP1A bind to?
Responda
-
Transpeptidase
-
Carboxypeptidase
-
Endopeptidase
Questão 3
Questão
Penicillin G is stable in gastric acid.
Questão 4
Questão
Which of the following penicillins have rapid elimination times less than or equal to 90 minutes?
Responda
-
Penicillin G
-
Nafcillin
-
Ampicillin
-
Piperacillin
-
Amoxicillin
-
All of the above
Questão 5
Questão
One RARE side effect of Penicillin G K+ is [blank_start]_______________[blank_end].
Questão 6
Questão
Select all that apply. The mechanism of action for penicillins are:
Responda
-
concentration dependent bactericidal action
-
time dependent bactericidal action
-
works best against rapidly dividing bacteria
-
works best against slowly dividing bacteria
-
inhibits transpeptidase activity of PBP3
Questão 7
Questão
Which of the following cause neutropenia?
Questão 8
Questão
Which of the following is the correct mechanism for how Polymyxins act as antibiotics?
Responda
-
Binds to ribosome 30s to prohibit protein synthesis
-
Disrupts the integrity of the baceterial cell wall by displacing calcium and magnesium
-
Inhibits the cross-linkages between the peptidoglycan polymer strands
-
Disrupts the integrity of the cell membrane by displacing calcium and magnesium
Questão 9
Questão
Which bacteria are susceptible to enzyme inactivation by beta lactamases?
Responda
-
Cephalosporins
-
Macrolides
-
Metronidazole
-
Tetracyclines
Questão 10
Questão
Penicillins are narrow spectrum drugs
Questão 11
Questão
Select all of the bactericidal antibiotics.
Responda
-
Macrolides
-
Penicillin
-
Tetracycline
-
Cephalexin
-
Aminoglycosides
-
Clindamycin
Questão 12
Questão
Which of the following is NOT a concern of antibiotic (antibacterial specifcially) use?
Questão 13
Questão
Which of the following is incorrect regarding Penicillin G/Penicillin V
Responda
-
Used for mixed aerobic-anaerobic infections
-
Used against gram positive and gram negative bacteria
-
One of these two can be used for treatment of Rheumatic fever
-
These are all correct
Questão 14
Questão
Which of the following is not an antistaphylococcal penicillin?
Questão 15
Questão
Penicillins work by inhibiting with enzyme?
Responda
-
Integrase
-
Peptidyl transferase
-
Transpeptidase
-
Transcriptase
Questão 16
Questão
Penicillin V is administered by IV only
Questão 17
Questão
Which of the following is NOT a possible adverse effect from penicillins?
Responda
-
Allergy
-
Phlebitis
-
Fungal overgrowth
-
Hemolytic anemia
Questão 18
Questão
Which of the following is true regarding aminopenicillins?
Responda
-
Resistant to beta lactamases
-
Narrow spectrum
-
Ampicillin has less side effects than amoxicillin
-
Effective against gonorrhea and meningitis
Questão 19
Questão
Select the following that are ineffective against beta lactamases:
Responda
-
Penicillin V
-
Penicillin G
-
Dicloxacillin
-
Amoxicillin
Questão 20
Questão
Which of the following best represents first generation cephalosporins?
Responda
-
Includes Cefotaxime and Ceftriaxone
-
Used for UTI (urinary tract infections) and soft tissue abscesses
-
Effective against Klebsiella and H influenza
-
Used for treatment of community-acquired pneumonia
Questão 21
Questão
Which of the following best describes the second generation of cephalosporins?
Responda
-
Drug of choice for surgical prophylaxis
-
Used to treat meningitis
-
Includes the drug Cefuroxime
-
Includes the drug Cefepime
Questão 22
Questão
Protein synthesis inhibitors are considered narrow spectrum antibiotics
Questão 23
Questão
Tetracyclines are broad spectrum antibiotics
Questão 24
Questão
Which of the following best matches the mechanism of tetracyclines?
Responda
-
Inhibition of beta 1-3 glycan of bacterial cell wall, preventing cross linkages
-
Becomes mechanically reduced to toxic metabolite, interacting with DNA
-
Binds to 50s subunit, preventing binding of tRNA to mRNA
-
Binds to 30s subunit, preventing binding of tRNA to mRNA
Questão 25
Questão
Which of the following are targeted by tetracyclines?
Questão 26
Questão
Which of the following is INCORRECT regarding macrolides?
Responda
-
Broad spectrum
-
Used as an alternative for patients allergic to penicillins
-
Can be bacteriostatic or bacteriocidal, depending on dose (concentration)
-
Kills gram positive and gram negative bacteria
Questão 27
Questão
Which of the following is incorrect regarding Chloramphenicol?
Questão 28
Questão
Chloramphenicol can cause gray baby syndrome.
Questão 29
Questão
Which of the following is NOT a use for Clindamycin?
Responda
-
Pseudomembranous colitis
-
Anthrax
-
Toxic shock syndrome
-
Odontogenic infection
Questão 30
Questão
Which of the following is NOT a concern for use of Clindamycin?
Questão 31
Questão
What is the clinical use of sulfonamides?
Questão 32
Questão
Sulfonamide is a structural analog of DFHR
Questão 33
Questão
Sulfonamides can cause which of the following adverse effects?
Responda
-
Photosensitivity
-
Pseudomembranous colitis
-
Neutropenia
-
Seizures
Questão 34
Questão
Clotrimazole can be used for UTI (urinary tract infections)
Questão 35
Questão
How do fluoroquinolones kill bacteria?
Responda
-
They bind to topoisomerase-DNA complexes and form an inactive complex
-
They bind to bacterial ribosomes 30s
-
They inhibit transpeptidases
-
They compromise the integrity of the bacterial cell membrane
Questão 36
Questão
Which of the following can cause Red Man Syndrome?
Responda
-
Penicillin
-
Erythromycin
-
Vancomycin
-
Sulfamethoxazole
Questão 37
Questão
Which of the following is NOT a side effect of drugs such as gentamicin, tobramycin, and amikacin?
Responda
-
nephrotoxicity
-
vestibular toxicity
-
tooth discoloration
-
cochlear toxicity
Questão 38
Questão
Which of the following cannot be used to treatment of MRSA?
Responda
-
Linezolid
-
Vancomycin
-
Streptogramins
-
Clindamycin
Questão 39
Questão
MRSA is resistant to ALL penicillins and cephalosporins
Questão 40
Questão
Which of the following does NOT increase risk of nephrotoxicity?
Responda
-
Aminoglycosides
-
Amphoterecin B
-
Cisplatin
-
Macrolides
Questão 41
Questão
Nystatin is not related to Amphoterecin B and can therefore be used systemically.
Questão 42
Questão
What type of fungal infection does nystatin treat?
Responda
-
Cryptococcal meningitis
-
Candida infections
-
Histoplasmosis
-
Asperillosis
Questão 43
Questão
Choose all of the trizoles.
Responda
-
Ketoconazole
-
Itraconazole
-
Fluconazole
-
Voriconazole
-
Miconazole
-
Clotrimazole.
Questão 44
Questão
What is the correct mechanism of azoles?
Responda
-
Disrupts microtubule function and inhibits dermatophyte growth
-
Binds to membrane Ergosterol
-
Inhibits viral DNA polymerase
-
Inhibits the lanosterol 14 alpha enzyme, preventing the conversion of lanosterol to ergosterol and disrupts the struction of fungal membrane
Questão 45
Questão
Which of the following is NOT an adverse effect of Azoles
Questão 46
Questão
Which of the following antifungals are used to disrupt microtubule (spindle) function?
Responda
-
Terbinafine
-
Griseofulvin
-
Echinocandins
-
Ketoconazole
Questão 47
Questão
Which of the following antifungals is used for onychomychosis and tinea?
Responda
-
Griseofulvin
-
Terbinafine
-
Echinocandins
-
Ketoconazole
Questão 48
Questão
Which antiviral drug prevents formation of DNA chain by inhibiting viral DNA synthesis?
Responda
-
Acyclovir
-
Ganciclovir
-
Raltegravir
-
Retrovir
Questão 49
Questão
Ganciclovir causes myelosuppression
Questão 50
Questão
What is the therapeutic use for Penicillin?
Responda
-
Drug of choice for streptococci, pneumococcal, and staphylococcal infections
-
Treat infections due to bacteria that have developed resistance to earlier generations of cephalosporins
-
Treatment of a broad range of gram positive and gram negative organisms
-
Treatment of patients who are unable to tolerate penicillins
Questão 51
Questão
What is the pharmacological class for Penicillin G?
Responda
-
Aminoglycoside, protein synthesis inhibitor
-
Fluroquinolone, bacterial DNA synthesis inhibitor
-
Natural penicillin, cell wall inhibitor, beta lactam
-
Mycolic acid inhibitor
Questão 52
Questão
What is the pharmacological class of Cefotaxime?
Responda
-
Beta lactam antibiotic, cell wall inhibitor
-
Tetracycline, protein synthesis inhibitor
-
Macrolide, protein synthesis inhibitor
Questão 53
Questão
Mechanism of action for Cefotaxime?
Responda
-
Inhibits cell wall synthesis
-
Inhibits bacterial protein synthesis and prevents replication
-
Inhibits synthesis of mycolic acid
Questão 54
Questão
Tetracycline mechanism of action?
Responda
-
Inhibits bacterial protein synthesis and prevents cell replication
-
Inhibits bacterial gyrase
-
Inhibits cell wall synthesis
Questão 55
Questão
What is the pharmacologic class for erythromycin?
Responda
-
Macrolide, protein synthesis inhibitor
-
Aminoglycoside, protein synthesis inhibitor
-
Beta lactam antibiotic
Questão 56
Questão
What is the mechanism of action for erythromycin?
Responda
-
Inhibits protein synthesis
-
Inhibits cell wall synthesis
-
Binds to peptidoglycan
-
Inhibits bacterial protein synthesis and prevents cell replication
Questão 57
Questão
What is the pharmacologic class for gentamicin?
Responda
-
Fluoroquinolone
-
Sulfonamide, folic acid inhibitor
-
Aminoglycoside, protein synthesis inhibitor
-
Mycolic acid inhibitor
Questão 58
Questão
What is the mechanism of action for Gentamicin?
Responda
-
Inhibits bacterial metabolism of folic acid
-
Inhibits protein synthesis, disrupting cell membrane and killing bacteria
-
Inhibits synthesis of mycolic acids
-
Inhibits bacterial DNA gyrase, interfering with bacterial replication and DNA error
Questão 59
Questão
Which of the following drugs would be used as treatment of UTI, GI, STDs, soft tissue, bone and joint infections?
Questão 60
Questão
What is the pharmacological class and mechanism of action for ciprofloxacin?
Responda
-
Fluoroquinolone, inhibits bacterial DNA gyrase
-
Mycolic acid inhibitor, inhibits mycolic acid
-
Aminoglycoside, inhibits protein synthesis
-
Sulfonamide, inhibits bacteiran metabolism of folic acid
Questão 61
Questão
Which drug would be used as a treatment for urinary tract infections, nocardiosis infections, and toxoplasmosis?
Questão 62
Questão
What is the mechanism of action and pharmacological class for trimethoprim-sulfamethoxazole?
Responda
-
fluroquinolone, inhibits bacterial DNA gyrase
-
sulfonamide, inhibits bacterial metabolism of folic acid
-
aminoglycoside, inhibits protein synthesis, disrupts membrane, kills bacteria
Questão 63
Questão
Which of the following drugs is a broad spectrum treatment of a wide range of helminth infections?
Responda
-
Mebendazole
-
Amphotericin B
-
Fluconazole
-
Cloroquine
Questão 64
Questão
What is the mechanism of action for Mebendazole?
Responda
-
Concentrates in food vacuoles of plasmodium residing in red blood cells
-
Inhibits microtubule formation and glucose uptake
-
Binds to ergosterol in fungal cell membranes and causes them to leak
-
Interferes with ergosterol synthesis
Questão 65
Questão
What is the therapeutic class for Amphotericin B?
Responda
-
Antihelminth
-
Antifungal
-
Antifungal (systemic)
-
Antimalarial
Questão 66
Questão
Which of the following drugs is the treatment of most fungi pathogenic to humans, the preferred drug for most systemic mycoses?
Responda
-
Fluconazole
-
Cloroquine
-
Mebendazole
-
Amphotericin B
Questão 67
Questão
Select all the following drugs that are polyenes.
Responda
-
Amphotericin B
-
Echinocandin
-
Griseofulvin
-
Nystatin
Questão 68
Questão
What is the therapeutic class for the drug Fluconazole?
Responda
-
Antihelminth
-
Antifungal
-
Antibacterial
-
Antiviral