Antihelminths/Antibacterials/Antifungal/Antiviral/Antimicrobial Susceptibility Testing

Descrição

Let's f*cking do this
Zainab Hassoun
Quiz por Zainab Hassoun, atualizado more than 1 year ago
Zainab Hassoun
Criado por Zainab Hassoun aproximadamente 9 anos atrás
12
0

Resumo de Recurso

Questão 1

Questão
Select all that apply. Which of the following are β-lactamase penicillins?
Responda
  • Ampicillin
  • Ticarcillin
  • Methicillin
  • Piperacillin
  • Nafcillin
  • Amoxicillin

Questão 2

Questão
What does PBP1A bind to?
Responda
  • Transpeptidase
  • Carboxypeptidase
  • Endopeptidase

Questão 3

Questão
Penicillin G is stable in gastric acid.
Responda
  • True
  • False

Questão 4

Questão
Which of the following penicillins have rapid elimination times less than or equal to 90 minutes?
Responda
  • Penicillin G
  • Nafcillin
  • Ampicillin
  • Piperacillin
  • Amoxicillin
  • All of the above

Questão 5

Questão
One RARE side effect of Penicillin G K+ is [blank_start]_______________[blank_end].
Responda
  • hyperkalemia

Questão 6

Questão
Select all that apply. The mechanism of action for penicillins are:
Responda
  • concentration dependent bactericidal action
  • time dependent bactericidal action
  • works best against rapidly dividing bacteria
  • works best against slowly dividing bacteria
  • inhibits transpeptidase activity of PBP3

Questão 7

Questão
Which of the following cause neutropenia?
Responda
  • Penicillin V
  • Piperacillin
  • Penicillin G
  • Amoxicillin-Clavulanic Acid Combo
  • Vancomycin
  • A, B, and D
  • A and C
  • B, C, and E

Questão 8

Questão
Which of the following is the correct mechanism for how Polymyxins act as antibiotics?
Responda
  • Binds to ribosome 30s to prohibit protein synthesis
  • Disrupts the integrity of the baceterial cell wall by displacing calcium and magnesium
  • Inhibits the cross-linkages between the peptidoglycan polymer strands
  • Disrupts the integrity of the cell membrane by displacing calcium and magnesium

Questão 9

Questão
Which bacteria are susceptible to enzyme inactivation by beta lactamases?
Responda
  • Cephalosporins
  • Macrolides
  • Metronidazole
  • Tetracyclines

Questão 10

Questão
Penicillins are narrow spectrum drugs
Responda
  • True
  • False

Questão 11

Questão
Select all of the bactericidal antibiotics.
Responda
  • Macrolides
  • Penicillin
  • Tetracycline
  • Cephalexin
  • Aminoglycosides
  • Clindamycin

Questão 12

Questão
Which of the following is NOT a concern of antibiotic (antibacterial specifcially) use?
Responda
  • Stevens Johnsons
  • Superinfection
  • Teratology
  • Increased effects of oral contraceptives

Questão 13

Questão
Which of the following is incorrect regarding Penicillin G/Penicillin V
Responda
  • Used for mixed aerobic-anaerobic infections
  • Used against gram positive and gram negative bacteria
  • One of these two can be used for treatment of Rheumatic fever
  • These are all correct

Questão 14

Questão
Which of the following is not an antistaphylococcal penicillin?
Responda
  • Amoxicillin
  • Methicillin
  • Nafcillin
  • These are all antistaphylococcal penicillins

Questão 15

Questão
Penicillins work by inhibiting with enzyme?
Responda
  • Integrase
  • Peptidyl transferase
  • Transpeptidase
  • Transcriptase

Questão 16

Questão
Penicillin V is administered by IV only
Responda
  • True
  • False

Questão 17

Questão
Which of the following is NOT a possible adverse effect from penicillins?
Responda
  • Allergy
  • Phlebitis
  • Fungal overgrowth
  • Hemolytic anemia

Questão 18

Questão
Which of the following is true regarding aminopenicillins?
Responda
  • Resistant to beta lactamases
  • Narrow spectrum
  • Ampicillin has less side effects than amoxicillin
  • Effective against gonorrhea and meningitis

Questão 19

Questão
Select the following that are ineffective against beta lactamases:
Responda
  • Penicillin V
  • Penicillin G
  • Dicloxacillin
  • Amoxicillin

Questão 20

Questão
Which of the following best represents first generation cephalosporins?
Responda
  • Includes Cefotaxime and Ceftriaxone
  • Used for UTI (urinary tract infections) and soft tissue abscesses
  • Effective against Klebsiella and H influenza
  • Used for treatment of community-acquired pneumonia

Questão 21

Questão
Which of the following best describes the second generation of cephalosporins?
Responda
  • Drug of choice for surgical prophylaxis
  • Used to treat meningitis
  • Includes the drug Cefuroxime
  • Includes the drug Cefepime

Questão 22

Questão
Protein synthesis inhibitors are considered narrow spectrum antibiotics
Responda
  • True
  • False

Questão 23

Questão
Tetracyclines are broad spectrum antibiotics
Responda
  • True
  • False

Questão 24

Questão
Which of the following best matches the mechanism of tetracyclines?
Responda
  • Inhibition of beta 1-3 glycan of bacterial cell wall, preventing cross linkages
  • Becomes mechanically reduced to toxic metabolite, interacting with DNA
  • Binds to 50s subunit, preventing binding of tRNA to mRNA
  • Binds to 30s subunit, preventing binding of tRNA to mRNA

Questão 25

Questão
Which of the following are targeted by tetracyclines?
Responda
  • Rickettsia
  • MRSA infections
  • P. vivax malaria
  • All are targeted by tetracyclines

Questão 26

Questão
Which of the following is INCORRECT regarding macrolides?
Responda
  • Broad spectrum
  • Used as an alternative for patients allergic to penicillins
  • Can be bacteriostatic or bacteriocidal, depending on dose (concentration)
  • Kills gram positive and gram negative bacteria

Questão 27

Questão
Which of the following is incorrect regarding Chloramphenicol?
Responda
  • It is bacteriostatic
  • Binds to 50s ribosome
  • Can be used to treat typhoid fever
  • Can be used for Neisseria gonorrhea

Questão 28

Questão
Chloramphenicol can cause gray baby syndrome.
Responda
  • True
  • False

Questão 29

Questão
Which of the following is NOT a use for Clindamycin?
Responda
  • Pseudomembranous colitis
  • Anthrax
  • Toxic shock syndrome
  • Odontogenic infection

Questão 30

Questão
Which of the following is NOT a concern for use of Clindamycin?
Responda
  • Neuromuscular block
  • Skin rashes
  • Pseudomembranous colitis
  • Fulminant hepatic necrosis

Questão 31

Questão
What is the clinical use of sulfonamides?
Responda
  • Skin infections
  • UTI (urinary tract infections)
  • Alternative for patients allergic to penicillins
  • Pseudomembranous colitis

Questão 32

Questão
Sulfonamide is a structural analog of DFHR
Responda
  • True
  • False

Questão 33

Questão
Sulfonamides can cause which of the following adverse effects?
Responda
  • Photosensitivity
  • Pseudomembranous colitis
  • Neutropenia
  • Seizures

Questão 34

Questão
Clotrimazole can be used for UTI (urinary tract infections)
Responda
  • True
  • False

Questão 35

Questão
How do fluoroquinolones kill bacteria?
Responda
  • They bind to topoisomerase-DNA complexes and form an inactive complex
  • They bind to bacterial ribosomes 30s
  • They inhibit transpeptidases
  • They compromise the integrity of the bacterial cell membrane

Questão 36

Questão
Which of the following can cause Red Man Syndrome?
Responda
  • Penicillin
  • Erythromycin
  • Vancomycin
  • Sulfamethoxazole

Questão 37

Questão
Which of the following is NOT a side effect of drugs such as gentamicin, tobramycin, and amikacin?
Responda
  • nephrotoxicity
  • vestibular toxicity
  • tooth discoloration
  • cochlear toxicity

Questão 38

Questão
Which of the following cannot be used to treatment of MRSA?
Responda
  • Linezolid
  • Vancomycin
  • Streptogramins
  • Clindamycin

Questão 39

Questão
MRSA is resistant to ALL penicillins and cephalosporins
Responda
  • True
  • False

Questão 40

Questão
Which of the following does NOT increase risk of nephrotoxicity?
Responda
  • Aminoglycosides
  • Amphoterecin B
  • Cisplatin
  • Macrolides

Questão 41

Questão
Nystatin is not related to Amphoterecin B and can therefore be used systemically.
Responda
  • True
  • False

Questão 42

Questão
What type of fungal infection does nystatin treat?
Responda
  • Cryptococcal meningitis
  • Candida infections
  • Histoplasmosis
  • Asperillosis

Questão 43

Questão
Choose all of the trizoles.
Responda
  • Ketoconazole
  • Itraconazole
  • Fluconazole
  • Voriconazole
  • Miconazole
  • Clotrimazole.

Questão 44

Questão
What is the correct mechanism of azoles?
Responda
  • Disrupts microtubule function and inhibits dermatophyte growth
  • Binds to membrane Ergosterol
  • Inhibits viral DNA polymerase
  • Inhibits the lanosterol 14 alpha enzyme, preventing the conversion of lanosterol to ergosterol and disrupts the struction of fungal membrane

Questão 45

Questão
Which of the following is NOT an adverse effect of Azoles
Responda
  • Steven Johnson
  • Increased levels of warfarin
  • Decreased fluconazole levels with isoniazid
  • Nephrotoxicity

Questão 46

Questão
Which of the following antifungals are used to disrupt microtubule (spindle) function?
Responda
  • Terbinafine
  • Griseofulvin
  • Echinocandins
  • Ketoconazole

Questão 47

Questão
Which of the following antifungals is used for onychomychosis and tinea?
Responda
  • Griseofulvin
  • Terbinafine
  • Echinocandins
  • Ketoconazole

Questão 48

Questão
Which antiviral drug prevents formation of DNA chain by inhibiting viral DNA synthesis?
Responda
  • Acyclovir
  • Ganciclovir
  • Raltegravir
  • Retrovir

Questão 49

Questão
Ganciclovir causes myelosuppression
Responda
  • True
  • False

Questão 50

Questão
What is the therapeutic use for Penicillin?
Responda
  • Drug of choice for streptococci, pneumococcal, and staphylococcal infections
  • Treat infections due to bacteria that have developed resistance to earlier generations of cephalosporins
  • Treatment of a broad range of gram positive and gram negative organisms
  • Treatment of patients who are unable to tolerate penicillins

Questão 51

Questão
What is the pharmacological class for Penicillin G?
Responda
  • Aminoglycoside, protein synthesis inhibitor
  • Fluroquinolone, bacterial DNA synthesis inhibitor
  • Natural penicillin, cell wall inhibitor, beta lactam
  • Mycolic acid inhibitor

Questão 52

Questão
What is the pharmacological class of Cefotaxime?
Responda
  • Beta lactam antibiotic, cell wall inhibitor
  • Tetracycline, protein synthesis inhibitor
  • Macrolide, protein synthesis inhibitor

Questão 53

Questão
Mechanism of action for Cefotaxime?
Responda
  • Inhibits cell wall synthesis
  • Inhibits bacterial protein synthesis and prevents replication
  • Inhibits synthesis of mycolic acid

Questão 54

Questão
Tetracycline mechanism of action?
Responda
  • Inhibits bacterial protein synthesis and prevents cell replication
  • Inhibits bacterial gyrase
  • Inhibits cell wall synthesis

Questão 55

Questão
What is the pharmacologic class for erythromycin?
Responda
  • Macrolide, protein synthesis inhibitor
  • Aminoglycoside, protein synthesis inhibitor
  • Beta lactam antibiotic

Questão 56

Questão
What is the mechanism of action for erythromycin?
Responda
  • Inhibits protein synthesis
  • Inhibits cell wall synthesis
  • Binds to peptidoglycan
  • Inhibits bacterial protein synthesis and prevents cell replication

Questão 57

Questão
What is the pharmacologic class for gentamicin?
Responda
  • Fluoroquinolone
  • Sulfonamide, folic acid inhibitor
  • Aminoglycoside, protein synthesis inhibitor
  • Mycolic acid inhibitor

Questão 58

Questão
What is the mechanism of action for Gentamicin?
Responda
  • Inhibits bacterial metabolism of folic acid
  • Inhibits protein synthesis, disrupting cell membrane and killing bacteria
  • Inhibits synthesis of mycolic acids
  • Inhibits bacterial DNA gyrase, interfering with bacterial replication and DNA error

Questão 59

Questão
Which of the following drugs would be used as treatment of UTI, GI, STDs, soft tissue, bone and joint infections?
Responda
  • Trimetoprim-sulfamethoxazole
  • Ciprofloxacin
  • Isoniazid
  • Gentamicin

Questão 60

Questão
What is the pharmacological class and mechanism of action for ciprofloxacin?
Responda
  • Fluoroquinolone, inhibits bacterial DNA gyrase
  • Mycolic acid inhibitor, inhibits mycolic acid
  • Aminoglycoside, inhibits protein synthesis
  • Sulfonamide, inhibits bacteiran metabolism of folic acid

Questão 61

Questão
Which drug would be used as a treatment for urinary tract infections, nocardiosis infections, and toxoplasmosis?
Responda
  • Ciprofloxacin
  • Gentamicin
  • Penicillin
  • Trimethoprim-sulfamethoxazole

Questão 62

Questão
What is the mechanism of action and pharmacological class for trimethoprim-sulfamethoxazole?
Responda
  • fluroquinolone, inhibits bacterial DNA gyrase
  • sulfonamide, inhibits bacterial metabolism of folic acid
  • aminoglycoside, inhibits protein synthesis, disrupts membrane, kills bacteria

Questão 63

Questão
Which of the following drugs is a broad spectrum treatment of a wide range of helminth infections?
Responda
  • Mebendazole
  • Amphotericin B
  • Fluconazole
  • Cloroquine

Questão 64

Questão
What is the mechanism of action for Mebendazole?
Responda
  • Concentrates in food vacuoles of plasmodium residing in red blood cells
  • Inhibits microtubule formation and glucose uptake
  • Binds to ergosterol in fungal cell membranes and causes them to leak
  • Interferes with ergosterol synthesis

Questão 65

Questão
What is the therapeutic class for Amphotericin B?
Responda
  • Antihelminth
  • Antifungal
  • Antifungal (systemic)
  • Antimalarial

Questão 66

Questão
Which of the following drugs is the treatment of most fungi pathogenic to humans, the preferred drug for most systemic mycoses?
Responda
  • Fluconazole
  • Cloroquine
  • Mebendazole
  • Amphotericin B

Questão 67

Questão
Select all the following drugs that are polyenes.
Responda
  • Amphotericin B
  • Echinocandin
  • Griseofulvin
  • Nystatin

Questão 68

Questão
What is the therapeutic class for the drug Fluconazole?
Responda
  • Antihelminth
  • Antifungal
  • Antibacterial
  • Antiviral

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