3953058
Descrição
Quiz por Phil Oklam, atualizado more than 1 year ago
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Criado por Phil Oklam
aproximadamente 9 anos atrás
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Questão 1
Questão
Where is the TATA box?
Responda
-
-31 to -26
-
-32 to -37
-
-2 to +4
-
+28 to +32
Questão 2
Questão
Where is Inr?
Responda
-
-2 to +4
-
-37 to -32
-
-31 to -26
-
+28 to +32
Questão 3
Questão
Where is DPE?
Responda
-
+28 to +32
-
-2 to +4
-
-37 to -32
-
-31 to -26
Questão 4
Questão
Where is BRE?
Responda
-
-37 to -32
-
-31 to -26
-
-2 to +4
-
+28 to +32
Questão 5
Questão
Which are true of CpG Islands?
Responda
-
rich in CG sequences
-
TXN occurs at a lower rate and at several start sites
-
C residues escape methylation
-
Methylation is associated with silencing of the gene
-
Extensively phosphorylated at CTD
-
Form a complex on TATA box to recruit RNA Pol II to the promoter
Questão 6
Questão
Which of the following are associated with RNA Pol II?
Responda
-
tRNA
-
snRNA
-
mRNA
-
miRNA
-
rRNA
Questão 7
Questão
Which RNA Polymerase is found in the nucleolus?
Responda
-
RNA Pol I
-
RNA Pol II
-
RNA Pol III
Questão 8
Questão
Which of the following is the correct sequence for the formation of PIC?
Responda
-
DABPolFEH
-
DBAPolFEH
-
DABPolEFH
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DAPolEBFH
Questão 9
Questão
Which GTF interacts with RNA Pol II during formation of PIC?
Responda
-
TFIIB
-
TFIID
-
TFIIA
-
TFIIE
-
TFIIH
-
TFIIF
Questão 10
Questão
What happens to RNA Pol II as it transcribes along RNA?
Responda
-
Phosphorylated at CTD
-
Methylated at CTD
-
Acetylated at CTD
-
Phosphorylated at N terminal tail
-
Acetylatetd at N terminal tail
Questão 11
Questão
Which of the following are true of TFIIH?
Responda
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It binds over Inr
-
It binds over TATA
-
It requires ATP to separate template strand
-
It requires NAD to separate template strand
-
It is released as RNA Pol II moves
-
It stays bound as RNA Pol II moves
-
Its CAK subunit contains kinase for phosphorylation
-
Its Core subunit contains kinase for phosphorylation
-
It contains helicases XPB and XPD
-
It contains helicases XPC and XPB
Questão 12
Questão
Which of the following is a trilobular structure containing TBP and TAFs?
Responda
-
TFIID
-
TFIIH
-
TFIIE
-
TFIIA
-
TFIIB
-
RNA Pol II
Questão 13
Questão
TBP directs assembly of PIC on the TATA complex and only requires TAFs to do so in a TATA-less promoter
Responda
- True
- False
Questão 14
Questão
Which of the following are UAS common sequence elements?
Responda
-
GC box
-
Octamer
-
CAAT box
-
HSE
-
SRE
-
BRE
-
DPE
Questão 15
Questão
What are leucine zippers, zinc fingers, homeodomains and helix loop helixes all examples of?
Responda
-
DNA binding domains
-
Activation domains
-
Enhancer elements
-
GTFs
Questão 16
Questão
Which of the following are true of Activation domains in activators?
Responda
-
They have a lack of sequence conservation
-
They are generally unstructured
-
They contain multiple short segments working together in an additive fashion
-
They can be gln rich, proline rich or acidic patches
Questão 17
Questão
How do activators work?
Responda
-
Promote binding of other activators
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Stimulate complex assembly (Recruitment)
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Release stalled RNA Pol II
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Modulation of chromatin
Questão 18
Questão
Which of the following are true of Mediator?
Responda
-
22 polypeptide complex
-
Comprised of a head, middle and tail
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Associates with RNA Pol through CTD
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Enhances PIC formation
-
Forms a bridge between RNA Pol II and activators
Questão 19
Questão
Which of the following is not a core histone?
Responda
-
H1
-
H3
-
H4
-
H2A
-
H2B
Questão 20
Questão
N terminal tails of histones are highly acidic
Responda
- True
- False
Questão 21
Questão
What do nucleosomes consists of?
Responda
-
2 x H2A-H2B dimers
-
H2A-H2B tetramer
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H1 linker histones
-
H3-H4 tetramer
-
2 x H3-H4 dimers
-
147 bp DNA wrapped around the octamer
-
471 bp DNA wrapped around the octamer
Questão 22
Questão
Mitotic chromosomes are condensed, interphase chromosomes occupy a distinct territory in the nucleus and are decondensed to about 100-400nm fibres
Responda
- True
- False
Questão 23
Questão
Which of the following switches off the Gal4 promoter?
Responda
-
Galactose
-
Glucose
Questão 24
Questão
Which of the following are methods of remodelling chromatin?
Responda
-
Histone variants
-
ATP dependent chromatin remodelling
-
Post translational modifications
Questão 25
Questão
Which histone does not express variants?
Responda
-
H4
-
H3
-
H1
-
H2A
-
H2B
Questão 26
Questão
Where do post translational modifications of histones occur?
Responda
-
N-terminal tail
-
Histone variants
-
C Terminal domain
-
DPD
-
TBP
Questão 27
Questão
The GNAT and MYST family are which enzymes?
Responda
-
HATs
-
HDACs
-
HKMTs
-
SWI/SNF ATPase
Questão 28
Questão
Histone methylation is readily reversible and has no affect on charge
Responda
- True
- False
Questão 29
Questão
Specific methylated lysines are recognised by specific proteins, which of the following are markers for repression?
Responda
-
H3 Lys 9
-
H3 Lys 27
-
H3 Lys 4
-
H3 Lys 36
Questão 30
Questão
Which of the following are SWI2/SNF2 ATPase subfamilies?
Responda
-
SWI2/SNF2
-
ISWI
-
CHD/Mi2
-
Ino80
Questão 31
Questão
What is the deletion of SWI/SNF associated with?
Responda
-
Tumours
-
Tumour suppression
Questão 32
Questão
Which class of HDACs is not zinc dependent?
Responda
-
Class III
-
Class I
-
Class II
-
Class IV
Questão 33
Questão
Regions of DNA that are hypoacetylated by HDACs are what?
Responda
-
Repressed
-
Activated
Questão 34
Questão
Which of the following is an example of an ATP dependent remodeller that commonly mediates repression?
Responda
-
NuRD
-
SWI/SNF
-
Ume3
-
Rpd3
-
Sin3
-
HP1
Questão 35
Questão
What is the name of the enzyme that methylates H3K9?
Responda
-
Suvar39
-
HP1
-
NuRD
-
Sin3
-
Ume6
Questão 36
Questão
Is Tsix or Xist on the antisense strand of DNA?
Responda
-
Tsix
-
Xist
Questão 37
Questão
What is the Role of NF-KB family of transcription factors?
Responda
-
Regulating inflammation, DNA damage, cell death, cell adhesion and proliferation.
-
The guardian of the genome.
Questão 38
Questão
NF-KB is pre-synthesised and retained within the cytoplasm in an active form bound to inhibitor protein IxB
Responda
- True
- False
Questão 39
Questão
Cellular [blank_start]stimulation[blank_end] > IkB phosphorylated > ubiquitination by E3 Ubiquitin ligase > degradation by 26S proteasome > NF-kB free to translocate to the nucleus.
Responda
-
stimulation
-
degradation
Questão 40
Questão
In diseased cells NF-kB control is lost (aberrantly nuclear)
Responda
- True
- False
Questão 41
Questão
Which of the following do all members of the mammalian NF-KB family contain?
Responda
-
Rel homology domains
-
Leucine zipper like domain
-
Non conserved transcription activation domains
-
PEST domains
-
ankyrin repeat motifs
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