451716
Descrição
Quiz por gina_evans0312, atualizado more than 1 year ago
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Criado por gina_evans0312
aproximadamente 11 anos atrás
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Questão 1
Questão
Describe the structure of Sec61
Responda
-
Trimeric- Alpha, beta and gamma subunits
-
Dimeric- 1A & 1B subunits
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Tetrameric- A, B, C & D subunits
Questão 2
Questão
What of the role of Sec 61 in ER transport?
Responda
-
Forms the pore itself
-
Binds the nascent polypeptide
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Folds the nascent polypeptide once it's passed through
Questão 3
Questão
Which pore-associated protein interacts with the signal recognition particle?
Responda
-
SR-alpha
-
SR-beta
-
SR-gamma
Questão 4
Questão
What is the role of the Sec62/63 complex?
Responda
-
Contains a J domain
-
Contains a G/F domain
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That signals the ATPase domain of Hsp40 in the ER (Bip)
-
That signals the ATPase domain of Hsp70 in the ER (Bip)
Questão 5
Questão
The Bip protein acts as a ratchet, pulling the protein through and preventing it moving backwards
Responda
- True
- False
Questão 6
Questão
The first Asparagine to enter the ER has what added to it?
Responda
-
Mannose
-
Acetyl-N Glucosamine
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Acetyl-N Galactosamine
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Moiety
Questão 7
Questão
The sugar added to the Asparagine is 12 residues long
Responda
- True
- False
Questão 8
Questão
Once the sugar has been added, what happens?
Responda
-
Glucosidase 1 & 2 remove glucose residues
-
Fructosidase 1 & 2 remove fructose residues
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Galactosidase 1 & 2 remove galactose residues
Questão 9
Questão
Once the residues have been removed, the protein is folded by one of which chaperones?
Responda
-
Calnexin
-
Calreticulin
-
Cal-Chaperonin
-
Calregulin
Questão 10
Questão
The Cal_ protein doing the folding will be bound to Erp57
Responda
- True
- False
Questão 11
Questão
What happens after the protein has been folded?
Responda
-
Another glucose is removed
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Another fructose is removed
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Another galactose is removed
Questão 12
Questão
Once the final residue is removed, the protein enters ERAD quality control, in which 2 things can happen
Responda
- True
- False
Questão 13
Questão
Other than exiting the ER as a correctly folded protein, what can happen after protein folding is complete?
Responda
-
Protein is reglycosylated
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Protein has mannose residues removed
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Protein has ions added
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Protein is degraded
Questão 14
Questão
In the case of a misfolding that the ER can correct, what protein is used to signal this?
Responda
-
Glycoprotein Glycosyl Transferase
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Mannosidase I
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EDM's
Questão 15
Questão
What proteins remove mannose resiudes of proteins to be degraded?
Responda
-
Glucosidase
-
Glycoprotein Glycosyl Transferase
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Mannosidase
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EDM's
Questão 16
Questão
Which protein leads a misfolded protein out of the ER to be degraded in the protesome?
Responda
-
Hrd1-E3
-
Glycoprotein Glycosyl Transferase
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Sec53
-
YDJ1
Questão 17
Questão
What is the role of Epr-57?
Responda
-
To make/break disulphide bonds
-
To cleave Signal Recognition Particle
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To bind Calreticulin to the membrane
Questão 18
Questão
Calnexin is membrane bound, Calreticulin is not
Responda
- True
- False
Questão 19
Questão
In Cal_ and Cal_, where on the protein to be folded to they bind?
Responda
-
Lectin domain- an exposed glucose residue
-
Pectin domain- an exposed Fructose residue
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Plectrin domain- an exposed mannose residue
Questão 20
Questão
The protein end not bound to the sugar residue binding site is bound to what?
Responda
-
The membrane
-
Erp-57
-
SSa
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