454011
Descrição
Quiz por gina_evans0312, atualizado more than 1 year ago
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Criado por gina_evans0312
quase 11 anos atrás
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Questão 1
Questão
Which of the following are caused by hydrolysis?
Responda
-
Nicks
-
Abasic Sites
-
Cross Links
-
Ds Breaks
Questão 2
Questão
Which of the following are caused by Radical Oxygen Species?
Responda
-
Bulky alkylation damage
-
Abasic sites
-
ds breas
-
ss breaks
-
Nicks
Questão 3
Questão
What causes Alkylation Damage?
Responda
-
S-adenosyl methionine
-
Radical oxygen species
-
Interacts with 6th O on guanine
-
Interacts with 3rd O on guanine
Questão 4
Questão
Methylation of guanine results in unstable base pairing
Responda
- True
- False
Questão 5
Questão
Over two cycles of replication, a methylated C-G will be replaced with an?
Responda
-
A-T
-
C-C
-
G-T
Questão 6
Questão
What protein catalyses Direct Reversal of Guanine methylation?
Responda
-
Alkyl-Guanine Transferase
-
Adenosyl-Guanine Transferase
-
Adenyl-Guanine Transferase
Questão 7
Questão
The enzyme involved in direct reversal catalyses the transfer of CH3 to the enzyme, killing it
Responda
- True
- False
Questão 8
Questão
How does the Direct Reversal enzyme 'flip out' the damaged guanine?
Responda
-
A helix-helix motif
-
A helix-turn-helix motif
-
A sheet-turn-sheet motif
Questão 9
Questão
The enzyme for direct reversal is not specific and so works globally
Responda
- True
- False
Questão 10
Questão
What is the reading head of the Direct Reversal enzyme made of?
Responda
-
Ala & Gly
-
Ser & Val
-
Tyr & Ser
Questão 11
Questão
The enzyme binds to the major groove using an HTH motif
Responda
- True
- False
Questão 12
Questão
Which happens first in the CH3 transfer?
Responda
-
Lys pushes H onto Tyr
-
Lys pushes CH3 onto Tyr
-
Tyr pushes H onto Lys
Questão 13
Questão
The new H+ pushes e-....
Responda
-
Onto CH3
-
Onto O bound to CH3
-
Onto Lys bound to CH3
Questão 14
Questão
The e- added to the O pushes the CH3 onto the Lysine
Responda
- True
- False
Questão 15
Questão
Which of the following recognises the widowed G and fills the gap?
Responda
-
Arg on the head of the reading head
-
Lys on the head of the reading head
-
Val on the head of the reading head
Questão 16
Questão
UV irradiation of _ causes _?
Responda
-
Consecutive pyrimidines
-
Consecutive purines
-
Opens a 5-6 bond
-
Opens a 3-4 bond
-
Opens a 4-6 bond
Questão 17
Questão
A phosphobutane photo-dimer is formed
Responda
- True
- False
Questão 18
Questão
Why is UV radiation dangerous?
Responda
-
It alters DNA conformation
-
So helicases make mistakes
-
Bases are deleted
-
Bases are duplicated
Questão 19
Questão
How do 6-4 lesions form?
Responda
-
An O is transfered from on thymine to another
-
An N is transfered from on thymine to another
-
A C is transfered from on thymine to another
Questão 20
Questão
Damage is recognised by bases
Responda
- True
- False
Questão 21
Questão
How does photolyase work on 6-4 bonds?
Responda
-
Uses light to reverse the reaction
-
Uses UV to reverse the reaction
-
Binds to DNA and excises damaged bases
Questão 22
Questão
A 'protein wedge' forces DNA apart so it can work
Responda
- True
- False
Questão 23
Questão
An e- from diazaflavin is removed by UV and is passed onto what?
Responda
-
FADH
-
NAD
-
NADH
Questão 24
Questão
The electron will hopefully break the distorted bonds
Responda
- True
- False
Questão 25
Questão
The photolyase process can only work once
Responda
- True
- False
Questão 26
Questão
Which residues bind to the phosphate backbone in photolyase?
Responda
-
Glu
-
Arg
-
Gln
Questão 27
Questão
What does the widowed base pair bind to?
Responda
-
Water
-
Methyl
-
ATP
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