471718
Descrição
Quiz por gina_evans0312, atualizado more than 1 year ago
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Criado por gina_evans0312
quase 11 anos atrás
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Questão 1
Questão
Define leukamia
Responda
-
Neoplastic proliferation of haemopeoietic or lymphoid cells
-
Neoplastic proliferation of lymphoid cells
-
Neoplastic proliferation of bone marrow
Questão 2
Questão
In acute leukaemia, abnormality occurs in mature cells
Responda
- True
- False
Questão 3
Questão
Acute leukaemia is described as a block in differentiation
Responda
- True
- False
Questão 4
Questão
Acute leukaemia is caused by acute proliferation of...
Responda
-
Myeloblasts
-
Lymphoblasts
-
Both (rare)
-
Both (most common)
Questão 5
Questão
What are the symptoms of chronic leukaemia?
Responda
-
No block in differentiation
-
Block in differentiation
-
Low proliferation
-
High proliferation
Questão 6
Questão
Acute leukaemia is recognised by a certain type of cell being up to 50% of bone marrow cells?
Responda
-
Blasts
-
Reticulocytes
-
Lympocytes
Questão 7
Questão
In A.L, there are often reticulocytes in the peripheral blood
Responda
- True
- False
Questão 8
Questão
Leukaemia is caused by clonal proliferation from a single cell
Responda
- True
- False
Questão 9
Questão
How can you (sometimes) differentiate between a myeloblast and a lymphoblast?
Responda
-
Myeloblasts have auer rods
-
Lymphoblasts have auer rods
-
Myeloblasts have a large, pale nucleus
-
Lymphoblasts have a large, pale nucleus
Questão 10
Questão
MUD stands for
Responda
-
Matched Unrelated Donor
-
Myeloblast Unknown Death
-
Myeloblasts Under Duress
Questão 11
Questão
Remission - no disease in the blood
Responda
- True
- False
Questão 12
Questão
Why use the Minimal Residual Disease (MUD)?
Responda
-
Assess chances at relapse/need for further treatment
-
Assess effectiveness of drug
-
Prevent remission
Questão 13
Questão
BMT - Bone Marrow Transplant
Responda
- True
- False
Questão 14
Questão
B Cell Acute Lymphoblastic Leukaemia has a poor prognosis for children but a good one for adults
Responda
- True
- False
Questão 15
Questão
Which of the following is has the poorer prognosis
Responda
-
Acute T-Cell Precursor Lymphoblastic
-
Acute B-Cell Precursor Lymphoblastic
Questão 16
Questão
What is found in cytogenetic testing of ALL?
Responda
-
Hyperploidy
-
Aneuploidy
-
Nullosomy
Questão 17
Questão
Which of the following are found in ALL cytochemistry?
Responda
-
MPX/SB are neg
-
MPX/SB are pos
-
PAS block pos
-
PAS block neg
Questão 18
Questão
Which of the following are found in Immunophenotyping for ALL?
Responda
-
CD19
-
CD7
-
CD10
Questão 19
Questão
What is true of AML?
Responda
-
Inc WBC
-
Dec RBC
-
Dec Plateles
-
Inc RBC
-
Inc Platelets
Questão 20
Questão
AML means there is no normal cells
Responda
- True
- False
Questão 21
Questão
What markers are used in Flow Cytometry to identify AML?
Responda
-
CD13
-
CD33
-
CD12
-
CD4
Questão 22
Questão
AML is more common in adult women
Responda
- True
- False
Questão 23
Questão
When is AML called 'De Novo'
Responda
-
When it occurs for the first time
-
If it occurs secondary to other malignancies
-
If it never relapses
Questão 24
Questão
Which of the following is common in AML (as opposed to ALL)
Responda
-
CNS leukaemia
-
Lymph, spleen and gum problems
-
Lymphodenopathy
Questão 25
Questão
Match up the following- A = Fatigue, B= Fever/Infections, C= Spontaneous Bruising
1 = Low Platelets 2= Low Hb 3 = Low WBC
Responda
-
A2, B3, C1
-
A1, B2, C3
-
A3 B2 C1
Questão 26
Questão
CML- accumulation of mature myeloid cells
Responda
- True
- False
Questão 27
Questão
Genetic anomalies in CML occur low down where they effect cells
Responda
- True
- False
Questão 28
Questão
What happens in 95% of cases to cause AML?
Responda
-
Chromosome 22 shortens
-
Linking BCR & ABL genes together
-
Chromosome 22 inverts
-
Chromosome 22 lengthens
Questão 29
Questão
In indentifying CML, immunophenotyping is useless
Responda
- True
- False
Questão 30
Questão
CML is more common in adult men
Responda
- True
- False
Questão 31
Questão
What is the WBC in CML?
Responda
-
>50 x 10^9/l
-
<30 x 10^9/l
-
>75 x 10^9/l
Questão 32
Questão
What will be found in a CML bone marrow sample?
Responda
-
Bone marrow is hypercellular
-
Bone marrow is hypocellular
-
Myeloid cells are present at all developmental stages
-
Inc Neutraphil Alkaline Phosphatase
-
Red Neutraphil Alkaline Phosphatase
Questão 33
Questão
Glivec stops CML cells dividing, but is expensive
Responda
- True
- False
Questão 34
Questão
CLL- Neoplastic proliferation of mature looking lymphocytes
Responda
- True
- False
Questão 35
Questão
What ususally happens in CML?
Responda
-
Lymphoids form masses in the bone marrow, spleen and lymph nodes
-
Lymphoids lyse and release contents as they are made poorly
-
Lymphs begin attacking body cells
Questão 36
Questão
In CLL, the lymph population can be over 300x the normal
Responda
- True
- False
Questão 37
Questão
What are smear cells?
Responda
-
Cells that rupture during a smear
-
Cells so malleable they look like smudges
-
Cells so deformed they form masses, which look like smears
Questão 38
Questão
In CLL, the bone marrow is <25% lymphocytes
Responda
- True
- False
Questão 39
Questão
What does immunophenotyping in CLL tell us?
Responda
-
Clonality
-
Which lymph cells they are
-
The markers
Questão 40
Questão
CLL is more common in old men
Responda
- True
- False
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