Questão 1
Questão
The Extrinsic Pathway operates on the initiating cell
Questão 2
Questão
What is the role of the Extrinsic Pathway?
Questão 3
Questão
The Intrinsic Pathway works on...
Responda
-
The endothelium
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The vW factor
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The platelet surface
Questão 4
Questão
The Intrinsic pathway is designed to generate thrombin bursts
Questão 5
Questão
Name the three steps of Coagulation
Responda
-
Initiation
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Amplification
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Propagation
Questão 6
Questão
What begins the Initiation phase?
Responda
-
Vascular injury initiates trigger factor
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Vascular injury exposes collagen for platelets to bind
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Vascular injury causes blood cells to lyse
Questão 7
Questão
Trigger factor activates VII, which activates smal amounts of
Questão 8
Questão
X & XI bind to platelets and produce small amounts of Thrombulin
Questão 9
Questão
Thrombin initiates Amplification
Questão 10
Questão
The platelets act as a surface for the assembly of what factor complexes?
Responda
-
IX & VIII
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Prethrombinase (X & V)
Questão 11
Questão
What happens in Propogation
Responda
-
Activated platelets/complexes generate Thrombin Burst
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Activated platelets/complexes generate Thrombulin Burst
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Activated platelets/complexes generate Thromblin Burst
Questão 12
Questão
What two things are required for Fibrin Clot formation?
Responda
-
Fibrinogen --> Fibrin
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F IIa
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F III
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F V
Questão 13
Questão
Thrombin production is the crucial step in haemostasis
Questão 14
Questão
The first step in Coagulation Disorder diagnosis is a family & drug history
Questão 15
Questão
Name the two main clinical presentation of coagulation disorders
Responda
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Bleeding in deep tissues
-
Bleeding in joints
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Flushed skin
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Easy cutting of skin
Questão 16
Questão
Prethrombin Time is anassessment of the _ Pathway
Questão 17
Questão
Prethrombin time is expressed as an international, normalised ratio
Questão 18
Questão
Activated Partial Thromboplastin Time is an indicator of...
Responda
-
Intrinsic pathway
-
Extrinsic pathway
Questão 19
Questão
Which of the following are not Coagulation Disorder investigations?
Responda
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Fibrinogen Assay
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FXIII Screen
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Thrombin Clotting Time
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Fibin Clotting Time
Questão 20
Questão
How do you evaluate increased prethrombin time?
Questão 21
Questão
How do you evaluate Activated Partial Thromboplastin Time (APPT)?
Questão 22
Questão
Lack o Factor X causes no symptoms
Questão 23
Questão
Factor I assay is used if bot PT and APTT is elevated
Questão 24
Questão
If both PT and APTT is normal, what is tested for?
Questão 25
Questão
Aquired Coagulation Deficiencies are caused by a lack of what?
Questão 26
Questão
What can cause Aquired Vit K deficiency?
Questão 27
Questão
Vit-K deficiency can be drug induced i.e. in the case of liver disease
Questão 28
Questão
Haemophilia A is caused by what?
Responda
-
Factor VIII deficiency
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Factor VI deficiency
-
Factor V deficiency
Questão 29
Questão
Haemophilia A is sex linked
Questão 30
Questão
Haemophilia B is a Factor IX deficiency
Questão 31
Questão
The mutations for Haemophilia A & B are found on which chromosome?
Questão 32
Questão
How do you identify Haemophilia B?
Responda
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Inc PT
-
Inc APTT
-
Factor IX assay
Questão 33
Questão
Von Willebrands disease is caused by a lack of factor
Questão 34
Questão
vW disease is detected by
Questão 35
Questão
Since many things can effect the levels of vWF, testing is difficult
Questão 36
Questão
vW disease can be qualitative or quantitative