473842
Descrição
Quiz por gina_evans0312, atualizado more than 1 year ago
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Criado por gina_evans0312
quase 11 anos atrás
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Questão 1
Questão
The vascular endothelium protects platelets from subendothelial aggregating substances i.e. collagen
Responda
- True
- False
Questão 2
Questão
Vasoconstriction around injured site helps coagulation how?
Responda
-
Reduced blood flow decreases pressure and loss of blood
-
Reduced blood flow brings coagulation factors into tissue contact more readily
-
Reduced blood flow decreases wall diameter, decreasing size of breach
Questão 3
Questão
Why is Fibrinolysis necessary?
Responda
-
It prevents inappropriate extension of the fibrin plug
-
Prevents clotting from damaging nearby cell
-
Prevents clotting in case of infected blood
Questão 4
Questão
To prevent inappropriate prevention of coagulation, where are coagulation inhibitors limited to?
Responda
-
Intact endothelium
-
Breached endothelium
-
Free flowing blood
Questão 5
Questão
Inhibitors are triggered by late products of coagulation
Responda
- True
- False
Questão 6
Questão
What is inhibited by the Tissue Factor Pathway Inhibitor?
Responda
-
FX reversibly
-
FX permanently
-
FVII
-
FV
Questão 7
Questão
Anthithrombin deactivates several enzymes of the coagulation system
Responda
- True
- False
Questão 8
Questão
Protein S & C work the same way
Responda
- True
- False
Questão 9
Questão
The Protein C pathway is initiated by what?
Responda
-
Thrombin
-
Antithrombomodulin
-
Antithrombin
Questão 10
Questão
Thrombomodulin works in the free flowing blood
Responda
- True
- False
Questão 11
Questão
Both thrombin and thrombomodulin work on the endothelial cell surface
Responda
- True
- False
Questão 12
Questão
What is the role of thrombomodulin?
Responda
-
Conversion of Thrombin to Antithrombin
-
Conversion of Thrombin to a Coagulation Inhibitor
-
Removal of platelets
Questão 13
Questão
Excess thrombin binds to thrombomodulin on intact cells, which allows it to be altered
Responda
- True
- False
Questão 14
Questão
Protein C acts as an anticoagulant by degrading Factors
Responda
-
V
-
VIII
Questão 15
Questão
Protein C needs Mg in order to function
Responda
- True
- False
Questão 16
Questão
Which of the following support Protein C activity?
Responda
-
Protein S
-
Inactive F V
-
Active F V
Questão 17
Questão
60% of patients with thrombophilia have a
Responda
-
Factor II deficiency
-
Protein C deficiency
-
Protein S deficiency
Questão 18
Questão
VTE = Venous Thromboembolism
Responda
- True
- False
Questão 19
Questão
What is thrombosis?
Responda
-
An increased liklihood of spontaneous clotting
-
An inability to form blood clots
Questão 20
Questão
Name the risk factors for thrombophilia
Responda
-
Alteration in blood components i.e. pregnancy
-
Circulatory stasis i.e. venous problems
-
Artificial surfaces i.e. a STENT
Questão 21
Questão
VTE occurs when blood coagulation overwhelms fibrogenlysis/anticoagulant mechanisms
Responda
- True
- False
Questão 22
Questão
Thrombophilia is linked to Lupus Anticoagulant Syndrome
Responda
- True
- False
Questão 23
Questão
Name some examples where Anticoagulation therapy is necessarry
Responda
-
Patient with a myocardial infarction (MI)
-
Patients with Lupus/APS
-
Deep Vein Thrombosis/ Primary Embolism
Questão 24
Questão
How is Heparin administered?
Responda
-
Intravenously
-
Subcutaneously
-
Ingestion
Questão 25
Questão
How does Heparin work?
Responda
-
Increases action of Antithrombin
-
Increases Protein C activity
-
Increases degredation of platelets
Questão 26
Questão
Why is Low Molecular Weight Heparin better?
Responda
-
100% bioavalibility
-
Longer half life
-
Less frequent osteoporosis
Questão 27
Questão
Dabigatran is only used in cases of Atrial Fibrilation
Responda
- True
- False
Questão 28
Questão
Dabigatran is a FX inhibitor, Rivaroxabin is a thrombin inhibitor
Responda
- True
- False
Questão 29
Questão
Warfarin works how?
Responda
-
Directly inhibits thrombin
-
Inhibits Vit K metabolism
-
Lyses platelets
Questão 30
Questão
Without Vitamin K, why is coagulation so much slower?
Responda
-
Non carboxylated factors cannot bind to Ca2+
-
Non carboxylated factors cannot bind to phosphorylated
-
Non carboxylated factors cannot be inhibited
Questão 31
Questão
Warfarin is used when all four clotting factors are low
Responda
- True
- False
Questão 32
Questão
What is the leading dose of Warfarin?
Responda
-
6mg for 3 days
-
3mg for 6 days
Questão 33
Questão
What test is used to monitor warfarin activity?
Responda
-
Prethrombin time
-
Activated Partial Thromboplastin Time
-
Fibrin Assay
Questão 34
Questão
What is the reference for Prethrombin Time?
Responda
-
Standard reference thromboplastin
-
Potency is ISI- International Sensitivity Index
-
Standard reference antithrombin
Questão 35
Questão
INR = Prethrombin Time/ Mean Normal Prethrombin Time
Responda
- True
- False
Questão 36
Questão
Match the dangerous INR ranges-
A= (2-3)
B= (3-4)
Responda
-
A= Prosthetic Heart Valves B = DVT
-
A = DVT B = Prosthetic Heart Valves
Questão 37
Questão
When using Warfarin, stop if the INR <2 for two consecutive days
Responda
- True
- False
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