Lecture 29 (Disorders of secondary haemostasis)

What are the major mechanisms responsible for defective secondary haemostasis?

Which mechanism is the most common cause of secondary haemostasis in domestic animals?

Clinical signs suggestive of defective secondary haemostasis may include?

In what domestic species are inherited coagulation factor deficiencies most often identified?

Deficiencies in relation to which of the below factors are yet to be confirmed in domestic animals?

Why does factor XI deficiency (haemophilia C) usually only cause mild bleeding?

When might deficiencies in factor XI result in massive bleeding?

The most severe haemorrhage is associated with inherited deficiencies of factor(s)?

Which inherited factor deficiency is the most common inherited coagulopathy in domestic animals and humans?

Haemophilia A it is inherited as an X-linked recessive disorder and manifests almost exclusively in hemizygous females (usually in the first six months of post-natal life)

Which factors are vitamin K-dependent? Choose the correct combination

A mutation in which gene (what does it encode for) causes a deficiency of the vitamin k-dependent factors?

Ingestion of which of the below can cause haemorrhage via antagonism of vitamin K epoxide reductase?

Mild intoxication by ingestion of anticoagulant rodenticides is a common cause of haemorrhage in cats and dogs. How can this be treated?

Dietary vitamin K deficiency although rare, is most commonly reported in what species of domestic animals?

What can cause vitamin K deficiency?

Which coagulation factors are deficient in the inherited coagulopathy recognised in Devon rex cats?

Where in the body are most of the coagulation factors produced?

What percentage reduction of functional liver mass causes significant decreases in coagulation factor activity?

Surprisingly, most animals with hepatic disease of enough severity to cause inadequate synthesis of coagulation factors do not bleed spontaneously, instead, they are at risk of uncontrollable haemorrhage if haemostatic capacity is challenged (e.g. if a liver biopsy is undertaken)

What is mandatory before subjecting an animal with known hepatic disease to a liver biopsy or other invasive surgery?

Why are animals with significant hepatic disease not only at risk of haemorrhage but also at risk of thrombosis?

Why would excessive fibrinolysis be an issue?

[blank_start]Fibrinolysis[blank_end]- enzymatic lysis of fibrin by plasmin [blank_start]Fibrinogenolysis[blank_end]- enzymatic lysis of fibrinogen by plasmin

In which conditions is excessive fibrinogenolysis thought to be a contributor to defective secondary haemostasis in domestic animals?

In which condition is excessive fibrinolysis a contributor to defective secondary haemostasis in domestic animals?

In what circumstances might a dog develop deficiency of vitamin K?