5395403
Descrição
Quiz por Sam Watkins, atualizado more than 1 year ago
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Criado por Sam Watkins
mais de 8 anos atrás
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Questão 1
Questão
what does NCE mean?
Responda
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New clinical entity
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National chemical entity
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National clinical entity
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New chemical entity
Questão 2
Questão
biological drugs (also known as [blank_start]biologics[blank_end]) are [blank_start]large[blank_end] molecule drugs. They are usually [blank_start]proteins[blank_end] such as [blank_start]peptides[blank_end] or antibodies but could be a nucleic acid. When discovered they are referred to as a [blank_start]NBE[blank_end]
Responda
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biologics
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chemologics
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biologists
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large
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small
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under 500 daltons
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proteins
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carbohydrates
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vitamins
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peptides
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starches
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glucose
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NBE
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NBB
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NBC
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NBA
Questão 3
Questão
a blockbuster drugs earns over $10 billion a year
Responda
- True
- False
Questão 4
Questão
where DON'T novel small molecules come from
Responda
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Nature
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Endogenous compounds
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In silico drug design
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you too drugs
Questão 5
Questão
which of the following is NOT a reason why analogue synthesis is required for endogenous lead compounds?
Responda
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natural ligand may have undesirable duration of action
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natural ligand may be metabolised too quickly
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natural ligand may be chemically unstable
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natural ligand may not have pharmacophore
Questão 6
Questão
synthetic drugs can be designed with computer modelling software
Responda
- True
- False
Questão 7
Questão
a me too drug has a similar structure to an existing drug, modified enough to make the compound [blank_start]novel[blank_end], but not so much that [blank_start]activity[blank_end] is affected.
Responda
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novel
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similar
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typical
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normal
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activity
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functional groups
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side effects
Questão 8
Questão
which one of the following is true
Responda
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side effects caused by drugs are never useful
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side effects from drugs can be useful by providing a new lead compound for the same condition
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side effects from drugs can be useful by providing a new lead compound for a different condition
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side effects from drugs are always useful even if no new lead compounds are found
Questão 9
Questão
The definition for a lead compound is - a novel compound discovered to have pharmaceutical potential which is a good starting point for drug development.
Responda
- True
- False
Questão 10
Questão
natural product derivatives are a natural derivative of a synthetic molecule
Responda
- True
- False
Questão 11
Questão
Natural product derivatives are used as drug compounds because they are [blank_start]less[blank_end] complex and [blank_start]smaller[blank_end] so easier to deliver, and possibly [blank_start]easier to deliver[blank_end]. The active part of the molecule may be used to save [blank_start]time and money[blank_end].
Responda
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less
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more
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equally as
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smaller
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larger
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have a higher LogP
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easier to deliver
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more lipinski like
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better formulated as creams
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time and money
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space
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wastage and filtration
Questão 12
Questão
Which of the following are challenges with natural products
Responda
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chrial centres which leads to 10,000's of isomers
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unusual functional groups causes complex chemistry
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difficult and ineffective multistep synthesis
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novel structures means scientists cannot predict LogP values
Questão 13
Questão
The large molecular weight of many natural products causes:
Responda
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I.V to often be the route of administration
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Good absorption through SGLT channels in the duodenal epithelium
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them to be stable in the stomach due to oxygen (ether) groups
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