enantiomers are non identical mirror images with a plane of symettry
Responda
True
False
Questão 2
Questão
enantiomers are a pair of stereoisomers that are non identical mirror images of eachother
Responda
True
False
Questão 3
Questão
diastereoisomers are
Responda
a pair of non identical stereoisomers that are not mirror images of eachother
a pair of non identical stereoisomers that are mirror images of eachother
a pair of identical mirror images with a plane of symettry
Questão 4
Questão
when describing chiral centres.. (select all that are true)
Responda
R/S classifies a chiral centre by the groups around it
D/L classifies a chiral centre by comparison to a reference compound glyceraldehyde
d/l classifies a molecule by the direction it rotates polarised light d is clockwise
+/- is the same as R/S. R = + S = -
Questão 5
Questão
Biosynthesis (synthesis of molecules in a biological system) is often stereoselective
Responda
True
False
Questão 6
Questão
Chiral synthesis in the laboratory is often very [blank_start]difficult[blank_end]. It is even harder to scale up to industrial scale. Two approaches to obtaining pure chiral molecules are [blank_start]Chiral separation[blank_end] (use a physical method e.g chromatography to separate the desired stereoisomer from a mixture) and [blank_start]The Chiral Pool[blank_end] (use a starting material that already contains a chriral centre.)
Responda
difficult
straightforward
fast
Chiral separation
chiral synthesis
HPLC/MS
The Chiral Pool
The chemical pool
chiral separation
chiral splitting
Questão 7
Questão
about 25% of drugs are administered as a racemate - an equal mixture of stereoisomers
Responda
True
False
Questão 8
Questão
some drugs are given as a single isomer which means a larger dose is required
Responda
True
False
Questão 9
Questão
which of the following is FALSE
Responda
for a pair of stereoisomers the one with the greater activity is the eutomer
for a pair of stereoisomers the one with the lesser activity is the distomer
the ratio between the distomer and the eutomer is the disumic ratio
Questão 10
Questão
select which apply about the ADME of stereoisomers:
Responda
during ABSORPTION by transmembrane proteins stereoisomers of chiral drugs can absorb differently
during ABSORPTION by passive diffusion stereoisomers of chiral drugs absorb differently
DISTRIBUTION leads to the stereoisomers having different effects because they bind to the plasma proteins
METABOLISM causes stereoisomers to be the broken down same as the same enzymes are used for both R and S forms of the drug
Questão 11
Questão
The development of a [blank_start]single[blank_end] isomer drug from a previously marketed [blank_start]racemate[blank_end] is known as the [blank_start]chiral switch[blank_end]
Responda
single
R-
multi
racemate
eutomer
tablet
distomer
chiral switch
chiral pool
chiral centre
Questão 12
Questão
which are advantages of the chiral switch?
Responda
improved biological activity
opportunity to market a new product
reduced side effects
simpler pharmacokinetics
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