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PHSI3011 02-2 Cardiac Electrophysiology #1 - Ventricular action potential

Description

Cardiac Electrophysiology divided into two lectures: 1 - Ventricular action potential (this one) 2 - Pacemaker action potentials Outline: - During exercise, the heart increases CO (Cardiac Output) - This is achieved by increasing HR and SV (Heart Rate and Stroke Volume) - These two lectures are devoted to the electrophysiological aspects of these changes - For most of us the terminal event will be a cardiac arrhythmia...but what causes them?
Michael Jardine
Quiz by Michael Jardine, updated more than 1 year ago
Michael Jardine
Created by Michael Jardine over 7 years ago
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Resource summary

Question 1

Question
The Ventricular Action Potential duration is:
Answer
  • ~300 ms; ~100X longer than APs in nerves and skeletal muscle.
  • ~300 ms; roughly equal to APs in nerves and skeletal muscle.
  • ~300 ms; ~100X shorter than APs in nerves and skeletal muscle.
  • 3-4 ms; ~100X longer than APs in nerves and skeletal muscle.
  • 3-4 ms; roughly equal to APs in nerves and skeletal muscle.
  • 3-4 ms; ~100X shorter than APs in nerves and skeletal muscle.

Question 2

Question
What is ICa?
Answer
  • Intracellular [Ca]
  • Inside [Ca]
  • Inward [Ca] current
  • Intracellular [Ca], measured relative to extracellular [Ca]

Question 3

Question
There are three main functions of ICa. These are? (select all that apply)
Answer
  • Provides inward current, which helps maintain long AP.
  • Provides a small fraction of the Ca, which triggers contraction.
  • Triggers Ca release from the SR (through the process of CICR - Calcium-Induced Calcium Release).
  • Helps marble meat properly.

Question 4

Question
Do Potassium channels contribute to the long action potential?
Answer
  • Yes
  • No

Question 5

Question
Potassium channels are largely responsible for which of the following? (not necessarily their only role, though)
Answer
  • Depolarisation
  • Repolarisation
  • [none of the above]

Question 6

Question
K[ATP] channels ("ATP" should be subscript) are:
Answer
  • Potassium-induced ATP channels.
  • ATP-induced Potassium channels.
  • Lack-of-Potassium -induced ATP channels.
  • Lack-of-ATP -induced Potassium channels.

Question 7

Question
Ischaemia is [blank_start]____[blank_end] of blood flow
Answer
  • restriction
  • an excess
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