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Appleton & Lange - Pharmaceutical Compounding

Description

Compounding is considered an intrinsic skill of the pharmacist. Pharmacists in institutional settings are expected to prepare parenteral admixtures, reconstitute parenteral powders and advise other health professionals in the handling, storage, administration, and potential incompatibilities of sterile products. This chapter reviews some of the compounding techniques, ingredients, and calculations that the practicing pharmacist may need to use.
Alexxis De Paz
Quiz by Alexxis De Paz, updated more than 1 year ago
Alexxis De Paz
Created by Alexxis De Paz over 6 years ago
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Resource summary

Question 1

Question
The prescription balance needed for weighing chemicals is currently designated as a Class ___ balance by the NBS.
Answer
  • I
  • II
  • III
  • P
  • Q

Question 2

Question
Which ONE of the following statements concerning single-pan electronic balances are replacements for the Class III balance is true?
Answer
  • they cannot be used since they are too accurate for routine weighings.
  • They are not suitable since the official shift and rider balance tests cannot be performed.
  • They may be used if they have a sensitivity requirement of 6 mg or better.
  • They are not recommended since their total weight capacity is often less than 120 g.
  • They may be used if their total weight capacity is not greater than 120 g.

Question 3

Question
Standards for chemicals being used for extemporaneous compounding are found in the
Answer
  • FDA Good Manufacturing Practices
  • USP/NF
  • Remington
  • Merck Index
  • USP/DI

Question 4

Question
A clinical trial using capsules requires 200 grams of theophylline monohydrate. How many grams of anhydrous theophylline must be used if its label also indicates the presence of 0.4% water? (mol. wt. anhydrous theophylline = 180; monohydrate theophylline = 198)
Answer
  • 181.1
  • 181.8
  • 182.5
  • 220
  • 220.8

Question 5

Question
How many mg of sodium fluoride are required to prepare this prescription?
Image:
Image (binary/octet-stream)
Answer
  • 0.5
  • 30
  • 50
  • 300
  • 500

Question 6

Question
Problem(s) that the pharmacist should anticipate in preparing this prescription include
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Image (binary/octet-stream)
Answer
  • caustic nature of sodium fluoride
  • poor water solubility of sodium fluoride
  • difficulty in weighing a small quantity of powder

Question 7

Question
The best choice of a diluent for stock powders, especially when preparing capsules, is
Image:
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Answer
  • ascorbic acid
  • lactose
  • sodium chloride
  • starch
  • talc

Question 8

Question
The pharmacist fills a #2 capsule and finds that the net weight of the powder is 40 mg less than needed. She may elect to
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Answer
  • use a #1 capsule
  • place additional powder into the head of the capsule
  • use a #3 capsule

Question 9

Question
NOTE: The pharmacist has 50-mg dimenhydrinate tablets; each weighing 200 mg, and 30-mg codeine sulfate tablets, each weighing 100 mg. Aspirin is available as a powder. Which of the following statements concerning the prescription is (are) true?
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Answer
  • The amount of codeine being consumed per day is an overdose.
  • There is a chemical incompatibility between dimenhydrinate and codeine.
  • The patient should be cautioned about the possibility of drowsiness from the capsules.

Question 10

Question
NOTE: The pharmacist has 50-mg dimenhydrinate tablets; each weighing 200 mg, and 30-mg codeine sulfate tablets, each weighing 100 mg. Aspirin is available as a powder. When compounding this prescription, the pharmacist must
Image:
Image (binary/octet-stream)
Answer
  • use a rubber spatula rather than stainless steel
  • add lactose to the formula
  • take into consideration the weight of the excipients in the codeine and dimenhydrinate tablets

Question 11

Question
NOTE: The pharmacist has 50-mg dimenhydrinate tablets; each weighing 200 mg, and 30-mg codeine sulfate tablets, each weighing 100 mg. Aspirin is available as a powder. The final weight of each capsule will be approximately
Image:
Image (binary/octet-stream)
Answer
  • 150 mg
  • 210 mg
  • 235 mg
  • 360 mg
  • 385 mg

Question 12

Question
Aminophylline is available in 20-mL ampules (25 mg/mL). How many ampules are needed daily for this order?
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Answer
  • 1
  • 2
  • 3
  • 4
  • 5

Question 13

Question
When reviewing this order, the pharmacist should
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Answer
  • inform the prescriber that an incompatibility exists between aminophylline solution & potassium chloride solution
  • inform the prescriber that the dose of aminophylline is too high
  • inform the nursing staff that the mixture must be protected from sunlight
  • inform the prescriber that aminophylline will precipitate when added to D5W
  • fill the order as written

Question 14

Question
Correct method(s) for preparing the previously shown admixture include
Image:
Image (binary/octet-stream)
Answer
  • adding the potassium chloride solution to the D5W, followed by the aminophylline solution
  • adding the aminophylline solution to the D5W first, then add the potassium chloride solution
  • mixing the aminophylline solution and the potassium chloride solution, then add this mixture to the D5W

Question 15

Question
The total amount (mg) of potassium administered in each admixture bottle is [K = 39.1; Cl = 35.5]
Image:
Image (binary/octet-stream)
Answer
  • 780
  • 1180
  • 2340
  • 4480
  • 2240

Question 16

Question
Which of the following commercial parenteral solutions would be incompatible with the original admixture?
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Answer
  • dobutamine
  • morphine
  • heparin
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