Question 1
Question
According to their mechanism of action the adrenergic agonists can be divided in:
Question 2
Question
α1-adrenoceptors are located on:
Question 3
Question
β1-adrenoceptors are located on:
Answer
-
postsynaptic neuronal endings
-
presynaptic neuronal endings
-
myocardial cells
-
juxtaglomerular apparatus in the kidney
Question 4
Question
β2-adrenoceptors are located on:
Question 5
Question
β3-adrenoceptors are located in:
Question 6
Question
Pharmacological effects of Epinephrine are:
Answer
-
positive chronotropic effect
-
blood pressure elevation
-
bronchial smooth muscles dilation
-
elevated levels of blood sugar
Question 7
Question
Indications for the clinical use of Epinephrine are:
Question 8
Question
Potential adverse drug reactions of Epinephrine are:
Answer
-
hypoglycaemia
-
arrhythmia
-
tremor
-
anxiety and restlessness
Question 9
Question
Clinical indications for prescribing α1-agonists are:
Answer
-
arterial hypotension
-
acute rhinitis
-
asthma attack
-
heart block
Question 10
Question
Pharmacological effects of the selective β2-agonists are:
Question 11
Question
Which of the following drugs are selective β2-agonists?
Answer
-
lsoprenalini sulfas
-
Orciprenalini sulfas
-
Salbutamol
-
Salmeterol
Question 12
Question
β2-agonists are indicated in:
Answer
-
bronchial asthma
-
digitalis intoxication
-
arterial hypertension
-
threatening abortion
Question 13
Question
Adverse drug reactions of β2-agonists are:
Answer
-
finger tremor
-
bronchial dilatation
-
hyperglycemia
-
tolerance
Question 14
Question
What are the main features of the indirect-acting adrenergic agonists?
Answer
-
stimulation of central nervous system
-
drug tolerance and dependence
-
have no effect on the cardio-vascular system
-
used for treatment of narcolepsy and attention deficiency hyperactivity disorder (ADHD)
Question 15
Question
Clinically desirable interactions can occur between β2-agonists and:(find correct answer)
Question 16
Question
Mechanisms of action of the presynaptic adrenolytics are:
Answer
-
blockade of the presynaptic α2-receptors
-
activation of the presynaptic α2-receptors
-
conversion to a “false“ neurotransmitter
-
blockade of the phosphodiesterase enzyme
Question 17
Question
Which of the following drugs act as agonists of the presynaptic α2-adrenoceptors?
Answer
-
Salbutamol
-
Clonidini hydrochloridum
-
α-Methyldopum (Dopegyt)
-
Sotalol
Question 18
Question
Pharmacological effects of Clonidin are:
Question 19
Question
Adverse drug reactions of Clonidin are:
Question 20
Question
For Methyldopa is true:
Answer
-
has antihypertensive effect
-
it is safe in pregnancy
-
could cause drug-induced parkinsonism
-
used to treat threatening abortion
Question 21
Question
Which of the following drugs are α1-adrenoblockers?
Answer
-
Prazosin
-
Doxazosin
-
Clonidin
-
Chlorpromazin
Question 22
Question
Pharmacological effects of Prazosin are:
Question 23
Question
Adverse drug reactions of α1-adrenoblockers are:
Answer
-
orthostatic collapse
-
hypokalemia
-
fluid retention
-
hypoglycaemia
Question 24
Question
Which of the following drugs are non-selective β-blockers?
Answer
-
Atenolol
-
Pindolol
-
Acebutolol
-
Propranolol
Question 25
Question
Which of the following drugs are selective β1-blockers?
Answer
-
Atenolol
-
Pindolol
-
Propranolol
-
Metoprolol
Question 26
Question
β-blockers are indicated in case of:
Answer
-
hypertension
-
bronchial asthma
-
arrhythmia
-
ischaemic heart disease
Question 27
Question
Pharmacological effects of B-blockers are:
Answer
-
bronchodilation
-
negative inotropic effect
-
positive chronotropic effect
-
negative chronotropic effect
Question 28
Question
β-blocker approved for topical use in treatment of glaucoma is:
Answer
-
Bisoprolol
-
Metoprolol
-
Timolol
-
Propranolol
Question 29
Question
When applied topically in the eye the B-blocker Timolol will:
Question 30
Question
Potential adverse drug reactions of β-blockers are.
Answer
-
hypoglycaemia
-
bronchoconstriction
-
hyperglycaemia
-
nightmares
Question 31
Question
For long-term treatment with β-blockers is true:
Answer
-
up-regulation of B-adrenergic receptors
-
down-regulation of B-adrenergic receptors
-
the therapy should be ceased abruptly
-
the therapy should not be ceased abruptly