Question 1
Question
.Which of the following statement is correct about viruses?
Answer
-
obligate intracellular parasites and have both RNA or DNA
-
obligate intracellular organism and have only RNA or DNA
-
they replicate by binary fission
-
Icosahedral helical form cannot exist without an envelope
Question 2
Question
.A 35 years old man who is HIV antibodies positive and has a CD 4 count of 85 cells. He recently had a seizure and an MRI scan indicates a lesion in the temporal lobe.A brain biopsy specimen reveals multinucleated giant cells with intra-nuclear inclusions.Which of the following is the most likely cause?
Question 3
Question
A 35 year old man who is HIV antibody positive and has a CD 4 count of 30 says “I can not remember the simplest things”.You are concerned about dementia. An MRI indicates several widely scattered lesions in the brain.Over the next 4 months he develops visual field defects,becomes paralysed and dies.Autopsy reveals that many neurons of the brain has lost myeline and contained intra-nuclear inclusions.Electrone microscopy reveals the inclusions contain non-enveloped viruses.Which of the following is the most likely cause?
Answer
-
Adenovirus
-
Cytomegalovirus
-
J-C virus
-
Coxsackie virus
Question 4
Question
A 12 year old girl had a seizure this morning and was rushed to the hospital. On examination her temperature was 400 C and she had no nuchal rigidity.CT scan revealed no abnormality. A spinal tap was done and the protein and glucose were normal.Gram stain of CSF shows no organism or polymorphs.Routine blood culture and CSF cultures grew no organisms.She was treated with various antibiotics but became comatose and died 2 days later.Autopsy of brain showed eosinophilic inclusion bodies in the cytoplasm of the neurons.Which of the following is the most likely cause?
Question 5
Question
Aspergillosis is recognized in tissues by the presence of
Answer
-
Budding cells
-
Septate hyphae
-
Metachromatic granules
-
Pseudohyphae
Question 6
Question
Which of the following media is used to culture fungi?
Answer
-
mac conkey medium
-
chocolate agar
-
sabouraud`s agar
-
owenstein jensen mediu
Question 7
Question
An AIDS patient with a persistent cough has shown progressive behavioral changes in the past few weeks after visiting a zoo. A CSF sample is collected and encapsulated yeast like organism is observed. What is the most likely organism?
Answer
-
aspergillus
-
cryptococcus neoformans
-
histoplasma
-
pseudomonas aeruginosa
Question 8
Question
The mycobacterium tuberculosis Contains complex lipids including Mycolic acids, which property is conferred to the mycobacterium by them?
Answer
-
Acid fastness
-
Freunds adjuvant
-
Caseation necrosis
-
Cord factor
Question 9
Question
Selective media needed for isolation of shigella species can be:
Answer
-
blood agar
-
ss agar
-
chocolate agar
-
sabaroud`s agar
Question 10
Question
Which of the following is true of Haemophilus influenzae?
Answer
-
Most invasive infections occur in infants during the neonatal period
-
The organism can be readily cultured on sheep blood agar in an environment of elevated CO2
-
Most human infections are acquired from domestic pets
-
Invasive infections are most commonly associated with encapsulated strains
Question 11
Question
Listeria monocytogenes shows which of the following characteristics?
Answer
-
It can grow at refrigerator temperatures (4 degree calcius)
-
It is an extracellular pathogen
-
It is catalase-negative
-
It is a gram-negative coccus
Question 12
Question
A diagnosis of diphtheria is confirmed by:
Answer
-
Microscopic appearance of organisms stained with methylene blue
-
Isolation of typical organisms from materials such as blood, showing invasiveness
-
Detection of " phage plagues in cultures of suspicious isolates
-
Demonstration of toxin production by a suspicious isolate.
Question 13
Question
In association with anaerobic fusiform bacteria gingivo-stomatitis and Vincent’s angina is caused by
Answer
-
Borellia burgdoferri
-
Borrelia vincenti
-
Leptospira interogans
-
Treponema carateum
Question 14
Question
Spore-forming anaerobic bacteria are usually present as normal flora of colon of animals, which one of them is responsible for causing flaccid paralysis after food poisoning.
Answer
-
C. perfringens
-
C. tetani
-
C. botulinum
-
C. difficile
Question 15
Question
A 35 years old man with the history of pain and swelling of his axillary lymph nodes, high grade fever, myalgias and generalized weakness. On examination the affected nodes are extremely tender. Pus from the node is sent for evaluation to microbiology lab.Waysonn’s staining of his specimen’s smear shows safety pin appearance of the organism. What is the most probable organism responsible for his illness?
Answer
-
Yerisinea pestis
-
fransicella tularensis
-
pasturella multocida
-
mycobacterium avium
Question 16
Question
Infection with the Malassezia furfur organism causes skin hypopigmentation.It is found most frequently in hot and humid regions. It is also responsible for causing one of the cutaneous mycosis. Infectin with malassezia furfur also causes which of the following disorders:
Answer
-
tinea capitis
-
tinea cruris
-
tinea nigra
-
tinea versicolor
Question 17
Question
Peptic ulcer disease: An ulcer is now known to be the result of an imbalance between aggressive and defensive mechanisms in the stomach and duodenum. Part of that imbalance can be attributed to infection by H. pylori. The organism is
Answer
-
Gram negative rod, urease negative,oxidase positive
-
Gram negative rod,urease positive,curved shaped
-
Gram negative rod,urease negative ,curved shaped
-
Gram negative rod,oxidase positive ,curved shaped
Question 18
Question
which of the following is RNA virus
Question 19
Question
the antiphagocytic property of group A strept. is associated with which of the following :
Answer
-
streptolysin S
-
M.protein
-
peptidoglycan
-
hyalurindase
Question 20
Question
general steps in viral multiplication cycle are
Answer
-
adsorption , penetration , rep;ication, maturation and release
-
endocytosis , uncoating , replication , assembly and budding
-
adsorption , uncaoting , duplication , assembly and lysis
-
endocytosis , penetration , replication , maturation , exocytosis
Question 21
Question
which of the following is associated with a deficiency of third component of complement C3
Answer
-
pyogenic infection
-
immune complex disease
-
SLE
-
xeroderma pigmentosum
Question 22
Question
which of the following components enchances the binding of antigen antibody complex to macrophages :
Question 23
Question
Naturally acquired active immunity would be most likely acquired through which of the following processes?
Question 24
Question
Which of the following substances will not stimulate an immune response unless they are bound to a larger molecule?
Answer
-
Antigen
-
Virus
-
Hapten
-
Antibody
Question 25
Question
The ability of the immune system to recognize self antigens versus nonself antigen is an example of:
Answer
-
Specific immunity
-
Tolerance
-
Cell mediated immunity
-
Antigenic immunity