Question 1
Question
[blank_start]Sterile[blank_end] means free from all microbiological contaminants i.e. living organisms, particles, and pyrogens.
[blank_start]Aseptic[blank_end] means produced from sterile components in a sterile environment – however it does NOT guarantee sterility.
Pharmacists generally work in [blank_start]aseptic[blank_end] conditions with [blank_start]sterile[blank_end] starting materials to prepare aseptic products.
Answer
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Sterile
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Aseptic
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Aseptic
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Sterile
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aseptic
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sterile
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sterile
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aseptic
Question 2
Question
Contamination/L
• Viable ([blank_start]live[blank_end]): Bacteria, fungi, and viruses.
Administration of viable material could result in fever; infection; septicemia; multi-organ failure; death.
• Non-viable: [blank_start]Undissolved[blank_end] particulate matter e.g. plastic or rubber material, glass shards, and chemical precipitates.
Non-viable material may [blank_start]occlude[blank_end] vessels e.g. if >12 μm they may become trapped in the lungs leading to respiratory failure and death.
Question 3
Question
What is laminar flow air?
Question 4
Question
Clean air eg a [blank_start]particle[blank_end]-free working environment, is made by drawing laminar air into the [blank_start]cabinet[blank_end], through the [blank_start]filtration[blank_end] system.
• HEPA-filtered air ([blank_start]high-efficiency particulate air[blank_end] filter)
• High airflow, [blank_start]constantly[blank_end] filtered and replenished
Question 5
Question
In horizontal air flow the product is protected but the operator is not. Vertical air flow protects both the product and operator.
Question 6
Question
Choose the incorrect statement.
Answer
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Critical points on equipment should never be exposed to clean air
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Starting materials are removed from their outer wrapping before entering the clean room – minimises the generation of particulate matter in the clean room.
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Needles are mostly used for one manipulation only, either withdrawing from a container or transferring into a container.
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After spraying with 70% ethanol, allow time for the ethanol to evaporate.
Question 7
Question
Critical Points on a Syringe:
Any ‘connection’ point:
• Tip of [blank_start]needle[blank_end]
• Hub of needle & tip of filter
• Hub of filter & tip of syringe
• Syringe [blank_start]plunger[blank_end]
Question 8
Question
Pharmacist involvement:
• [blank_start]Preparation[blank_end] of cytotoxics
– Preserve safety of self and product
• [blank_start]Dispensing[blank_end] of cytotoxics
– Calculations
– Precise and accurate [blank_start]instructions[blank_end] must be given
• Advising nursing staff how to administer cytotoxic products
• Providing medicines information and advice
Answer
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Preparation
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Dispensing
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instructions
Question 9
Question
Administration of any IV medicine carries a risk of extravasation ([blank_start]leakage[blank_end] from vein into tissue). This is NOT a side effect. Regarding extravasation:
• Common term is “tissued”
• Can result in pain, swelling, and [blank_start]damage[blank_end] at the injection site
• If the drug is a [blank_start]vesicant[blank_end] (causes blistering) it can cause severe tissue damage and necrosis (and can continue for months after injury)
• Oncology nurses take [blank_start]extreme[blank_end] care to ensure extravasation does not occur
• Patients must be educated to report any discomfort and/or pain [blank_start]during[blank_end] administration
Answer
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leakage
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damage
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vesicant
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extreme
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during
Question 10
Question
Central lines (catheters for administration)
• Via jugular or subclavian [blank_start]vein[blank_end] with tip at superior vena cava (e.g. Hickman port, double/single lumen).
• PICC (peripherally-inserted central catheter), starts at the [blank_start]arm[blank_end] and is placed centrally
Question 11
Question
Cytotoxic drugs are potentially lethal especially if delivered via the [blank_start]wrong[blank_end] route.
• Dose varies [blank_start]greatly[blank_end] between intramuscular (IM), intravenous (IV), and intrathecal (IT – the space that holds the [blank_start]CSF[blank_end]) routes
• The formulation may vary between routes
eg [blank_start]Methotrexate[blank_end] is often given intrathecally, but [blank_start]vincristine[blank_end] is fatal by this route
Answer
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wrong
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greatly
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CSF
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vincristine
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Methotrexate