Question 1
Question
The use of atypical antipsychotic or second-generation antipsychotic medications in children, adolescents and adults is associated with a number of side effect issues. Which of the following is of most concern for the physical well-being of those so treated
Question 2
Question
: In the treatment of major depression in adolescents many of the drugs come with a so-called “black box” warning. What does this mean in practical terms?
Answer
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The drugs are ineffective in children
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The drugs have been associated with an increase in suicidal ideation
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The side effects are more severe in adolescents than in adults
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The drugs cause sleep disturbance
Question 3
Question
: In treating bipolar disorder which of the following classes of agents is most likely to be prescribed?
Answer
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Anticonvulsant agents
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Stimulants
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Benzodiazepines
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Atomoxetine
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Antidepressants
Question 4
Question
Among the various classes of medication used to treat major depression in adolescents and adults agents from which general class are most likely to be used as a drug of first choice?
Answer
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Tricyclic antidepressants (for example imipramine)
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SNRIs (venlafaxine for example)
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SSRIs (e.g., Fluoxetine)
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Atypical antipsychotic (olanzapine for example)
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Benzodiazepine (diazepam for example)
Question 5
Question
Most textbooks would suggest that antidepressant drugs exert their therapeutic effects when?
Answer
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Immediately
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After two to three days
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Only at the recommended doses
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Provided there are no co-morbid somatic illnesses
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Within two to four weeks with optimal benefits after six to eight weeks
Question 6
Question
In the treatment of Bipolar Disorder there are several alternatives to the use of lithium as a prophylactic agent. From among the following which agents have been used in clinical practice?
Answer
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Antidepressants
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Some atypical antipsychotics
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Some anticonvulsant medications
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Antidepressants and some atypical antipsychotics
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Some atypical antipsychotics and Some anticonvulsant medications
Question 7
Question
In the treatment of bipolar disorder lithium salts are frequently used. It is described as having a narrow therapeutic index. What does this mean?
Answer
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Lithium is not safe for use
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There is a wide gap between toxic and therapeutic doses of the drug
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Blood levels need monitoring to check that concentrations are within the therapeutic range
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The drug should only be administered to men
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Lithium is not useful in any other disorder
Question 8
Question
The use of anticonvulsant drugs to treat bipolar disorder is associated with a number of side effects. The most serious, indeed life threatening, of these is:
Question 9
Question
In recent years the so called “atypical” or second generation antipsychotic drugs have been introduced for the treatment of schizophrenia. Which statement best characterises the difference between typical or first generation and atypical antipsychotic medications?
Answer
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Atypicals are characterised by less EPS symptoms and little or no tardive dyskinseia
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Atypical antipsychotic drugs are not as effective as typicals
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Typical antipsychotic drugs never cause Parkinson like symptoms
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Typical antipsychotic drugs do not affect the secretion of prolactin
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Atypical antipsychotic drugs do not affect dopamine D2 receptors
Question 10
Question
Venlafaxine, duloxetine and desvenlafaxine are all antidepressant medications from the same general class of agents. To which class of agent are they usually considered to belong?
Answer
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Monoamine oxidase inhibitors
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Dual acting agents or SNRIs
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Weak antidepressants
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Herbs and antioxidants
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Tricyclic antidepressants
Question 11
Question
Selective serotonin reuptake inhibitors such as fluoxetine are effective treatments for major depression. When first administered they can cause a number of side effects. Which of the following effects may cause the drug to be stopped due to an association with increased suicidal ideation, especially in adolescents?
Answer
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Orthostatic hypotension
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Lower toxicity in overdose
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Fewer sexual side effects than tricyclic antidepressants
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Transient increase in agitation and anxiety (akathisia)
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Haematological disorders
Question 12
Question
For antidepressants of the monoamine oxidase inhibitor type which of the following statements is true?
Answer
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Are associated with a so called ‘cheese effect
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Are not as effective as other antidepressant medications
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Are not associated with an effect on blood pressure
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Work more rapidly than tricyclic antidepressants
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Accelerate the breakdown of monoamines in the brain
Question 13
Question
Dry mouth, blurred vision, constipation, urinary retention are frequently observed in patients receiving tricyclic antidepressants. This constellation of symptoms is referred to as:
Answer
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Adrenergic syndrome
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Antihistamine effects
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Beta blockade
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“Cheese effect”
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Anticholinergic symptoms
Question 14
Question
Bipolar disorder is often treated with atypical antipsychotics or second-generation antipsychotic medications. Associated with their use are a number of side effects. Which of the following is of most concern for the physical well-being of those so treated?
Question 15
Question
Sexual dysfunction in men and women is increasingly recognised as a side effect of the administration of which of the following classes of antidepressants?
Question 16
Question
Bipolar disorder is conceptualised as having three separate phases each often requiring different pharmacological management strategies. In an acute manic phase which medication is most likely to be chosen as a first option?
Answer
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Dexamphetamine.
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Antidepressant.
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Atypical antipsychotic.
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Zopiclone.
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Beta-blocker.
Question 17
Question
A goal of maintenance treatment in bipolar disorder is to stabilise mood. For this purpose a prophylactic agent is likely to be chosen. Which of the following medications has mood stabilizing properties?
Answer
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Amphetamine.
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Diazepam.
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Sertraline.
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Lithium.
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Tetrahydrocannabinol.
Question 18
Question
What is regarded as the main pathological feature leading to the development of Alzheimer’s dementia?
Answer
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Presence of plaques and tangles in the cells of the brain
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Changes in brain volume
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Structural changes in synapses of the brain
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Loss of brain connectivity
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Changes in the olfactory system
Question 19
Question
Many drugs have effects on the central nervous system resulting in the alleviation of anxiety. Which of the following drugs is used predominantly as an antianxiety agent?
Answer
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Amphetamine
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Cocaine
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Diazepam
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Haloperidol
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L-DOPA
Question 20
Question
: In the cannabis plant (cannabis sativa) the flowering tops contain the highest concentration of the active ingredient. What is the active ingredient responsible for its psychological effects?
Question 21
Question
Stimulant medications are most likely to be prescribed to children with Attention Deficit Hyperactivity Disorders (ADHD) to control their symptoms. Which of the following medications would be classified as stimulants?
Answer
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Clonidine
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Fluoxetine
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Atomoxetine
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Dexamphetamine
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Clozapine
Question 22
Question
The use of stimulants in the treatment of children with ADHD is associated with the emergence of some side effects. Which of the following are side effects of typical stimulant agents?
Question 23
Question
Benzodiazepines are a group of medications usually used in the treatment of anxiety disorders or insomnia. They are less likely to be used clinically nowadays because they are associated with some potentially significant effects. Which of the following choices is best describes the concerns with benzodiazepines?
Question 24
Question
The condition of ADHD is associated with some abnormal findings in brain circuits on neuroimaging. The circuits identified use certain neurotransmitters for communication between neurons. The involvement of these neurotransmitters has been used as the basis for prescribing medications. Which of the following neurotransmitters has most closely been associated with ADHD?
Question 25
Question
Alzheimer disease is a progressive neurodegenerative disorder involving the loss of neurones within the brain. One strategy for the restoration of cognitive performance has been to use drugs affecting which specific neurotransmitter?
Answer
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Serotonin
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Acetylcholine
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Glycine
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GABA
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Dopamine