Cancer 1

Question 1

Question

What is the most common cancer in males?

Answer

Non Melanoma Skin Caner
Prostrate cancer
Lung cancer
Colorectal

Question 2

Question

What is the most common cancer in females?

Answer

Breast cancer
Non Melanoma Skin Cancer
Lung cancer
Colorectal cancer

Question 3

Question

How do Tobacco smoke and coal tar form cancer?

Answer

Forming aldehyde adducts
Forming DNA adducts

Question 4

Question

Exposure to what substances increases the liver cancer incidence?

Answer

Aflatoxin B1 and Hepatitits B
alcohol and tobacco

Question 5

Question

Protooncogene inheritance is classified as

Answer

Loss of function
Gain of function
Both
None of the above

Question 6

Question

Tumor suppressor gene inheritance is classified as?

Answer

Loss of function
Gain of function
Both
None of the above

Question 7

Question

In Familial cancer syndrome what is the gene that is mutated?

Answer

RET
MET(HGFR)
BCR
ABL

Question 8

Question

In Hereditary renal papillary carcinoma what is the gene that is mutated?

Answer

MET (HGFR)
RET
ABL
BCR

Question 9

Question

What is the translocation in follicular lymphoma

Answer

14:18
15:17
9:22
11:22

Question 10

Question

CML translocation is seen between what chromosomes?

Answer

9:22
15:17
11:22
14:18

Question 11

Question

What translocation is seen in Promyelocytic leukemia?

Answer

15:17
9:22
11:22
14:18

Question 12

Question

Translocation in Ewing's Sarcoma?

Answer

11:22
14:18
15:17
9:22

Question 13

Question

How does translocation cause cancer?

Answer

The novel product promotes proliferates like an oncogene
It makes a transcription factor that promotes proliferation
It makes a novel factor that inhibits apoptosis
None of the above

Question 14

Question

N-MYC is amplified in what tumor?

Answer

Neuroblastoma
Pheochromocytoma
Wilms tumor

Question 15

Question

In Knudson's 2 hit model what are the mechanisms for the second hit?

Answer

Loss of heterozygosity
Deletion
recombination
non-dysjunction
All of the above

Question 16

Question

Which of the following is not inherited by Autosomal Dominance?

Answer

Retinoblasotma
Li-Fraumeni Syndrome
Hereditary Breast cancer
Neurofibromatosis 1
FAP / HNPCC
None of the above

Question 17

Question

What are the mutations in FAP?

Answer

Question 18

Question

What are the mutations in HNPCC?

Answer

MLH 1 and 3
MSH 2 and 6
PMS 1 and 2
All of the above

Question 19

Question

Wnt binds to Frizzled and activates dishevelled which in turn inhibits APC/Axin/GSK-3Beta

Answer

True
False

Question 20

Question

Beta Catenin is not phosphorylated so not destroyed so it accumulates and promotes proliferation

Answer

True
False

Question 21

Question

Microsatellite instability/ replication error positive is seen in HNPCC - true or false

Answer

True
False

Question 22

Question

What are the mutations that are seen in sporadic cancer?

Answer

PTEN
TGFBR2
SMAD4
WT1
All of the above

Question 23

Question

In Xeroderma Pigmentosum the most common nucleotide repair mechanism is excision endonuclease deficiency - true or false?

Answer

True
False

Question 24

Question

In Ataxia Telegectasia (ATM) mutation of what gene promotes proliferation?

Answer

p53
RB
myc
none of the above

Question 25

Question

Bloom syndrome - DNA helicase deficiency - true or flase

Answer

True
False

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	Created by ivenkat over 9 years ago