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ivenkat
Quiz by ivenkat, updated more than 1 year ago
ivenkat
Created by ivenkat over 9 years ago
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Question 1

Question
All of the following are true about Henderson-Hasselbalch equation except
Answer
  • If pKa < pH then A- > HA i.e. dissociated
  • if pKa > pH, then HA > A- i.e. not dissociated
  • When Concentration of A- and HA are equal then pH=pKa
  • None of the above

Question 2

Question
All of the following are sequence of events in the transport of bicarbonate
Answer
  • Tissues like liver generate CO2 by cellular respiration
  • CO2 + H2O in the presence of carbonic anhydrase in RBC results in H2CO3
  • H2CO3 dissociates into H+ and HCO3-
  • H+ is taken up by the Hemoglobin and HCO3- is exchanged for PO4-

Question 3

Question
All of the following regarding Oxy-Hb dissociation curve are true except?
Answer
  • Shift to the right means more O2 is released to the tissues
  • Low pH, high PCO2, increased H+ concentration and increased 2,3DPG all cause a shift to the right
  • Hemoglobin and Myoglobin both have the same type of curve

Question 4

Question
Proton binding by Hb reduces oxygen affinity is called the Bohr effect
Answer
  • True
  • False

Question 5

Question
Oxygen has >200 times greater affinity for Hb than CO
Answer
  • True
  • False

Question 6

Question
all of the following regarding enzymes are true except?
Answer
  • The velocity of all enzyme reactions is dependent on the concentration of the Substrate
  • The initial velocity of product formation (vi) proportional to Concentration of ES
  • Velocity continues to increase with increasing substrate concentration

Question 7

Question
In competitive inhibition Vmax is decreased and Km is unchanged, in noncompetitive inhibition Vmax remains unchanged and Km is changed
Answer
  • True
  • False

Question 8

Question
All of the following regarding allosteric enzyme are correct except
Answer
  • Regulation via allosterism can be more powerful since activators don't use catalytic site
  • Inhibitors have stronger effect than at active site
  • changes can be rapid
  • Allosteric enzyme has a sigmoid curve
  • None of the above
  • all of the above

Question 9

Question
All of the following are irreversible steps in Glycolysis except
Answer
  • Glucose to Glucose 6 phosphate
  • Fructose 6 phosphate to Fructose 1,6 bisphosphate
  • PEP to Pyruvate
  • Glyceraldehyde 3 phosphate to 1,3 Bisphosphoglycerate

Question 10

Question
All of the following regarding Glucokinase are true except?
Answer
  • low Km for glucose
  • High Vmax for glucose
  • indirectly inhibited by fructose 6 phosphate and stimulated by glucose
  • Not inhibited by Glucose 6 phosphate
  • Mutation of this enzyme cause MODY 2 and also play a role in gestational diabetes

Question 11

Question
All of the following about PFK1 are true except
Answer
  • PFK 1 irreversibly commits G6P to glycolysis
  • PFK1 is allosterically inhibited by ATP
  • PFK1 is allosterically activated by AMP and fructose 2,6 bisphosphate
  • none of the above

Question 12

Question
Pyruvate Kinase deficiency causes hemolytic anemia
Answer
  • True
  • False

Question 13

Question
All of the following are true about Warburg effect except?
Answer
  • Proliferating cells get ATP from glycolysis not Oxidative Phosphorylation
  • Glycolysis is up regulated by oncogenes
  • Damaged mitochondria so no TCA cycle only glycolysis
  • Works for all body cancers including brain

Question 14

Question
All of the following about PDC (pyruvate dehydrogenase complex) are true except
Answer
  • Co factor for E1 is B1, Cofactor for E2 is lipoic acid and cofactor for E3 is FAD/NAD
  • E1 is X linked
  • PDH deficiency causes lactic acidosis and a type of subacute necrotizing encephalomyelopathy (Leigh disease)
  • None of the above

Question 15

Question
Following all are the fates of pyruvate except
Answer
  • Transmination becomes Alanine
  • Dehydrogenation becomes acetyl CoA (by PDH in the presence of Oxygen)
  • In the absence of oxygen becomes lactate
  • Carboxylation to Oxaloacetate
  • none of the above

Question 16

Question
PDH kinase inactivates PDC
Answer
  • True
  • False

Question 17

Question
The only substrate level ATP production in TCA cycle is from succinyl CoA to succinate
Answer
  • True
  • False

Question 18

Question
TCA cycle produces NADH for OxPhos, OxPhos produces ATP
Answer
  • True
  • False

Question 19

Question
All of the following about ETC is correct except?
Answer
  • Complex I cofactor is NADH
  • Complex II - Cofactor FADH2
  • CoQ only component of ETC not protein bound
  • Complex III - cytochrome b-c1
  • ETC reduces NADH and FADH2

Question 20

Question
All of the following statements are true except
Answer
  • Rotenone is inhibitor of complex 1 in ETC
  • Inhibition of Complex 1 causes a decrease in proton gradient
  • Oligomycin is an ATP synthase inhibitor - which increases the proton gradient
  • 2,4 Dinitrophenol is an uncoupling agent - which increases proton gradient

Question 21

Question
The primary carbon-containing molecules that are substrates for gluconeogenesis are alanine from protein degradation, lactate from anaerobic glycolysis and glycerol from fat
Answer
  • True
  • False

Question 22

Question
All of the following are gluconeogenic enzymes except
Answer
  • Pyruvate carboxylase
  • PEP carboxykinase
  • Fructose 1,6 bisphosphatase
  • Glucose 6 phosphatase
  • None of the above

Question 23

Question
All of the following are true about HMP shunt
Answer
  • Provides a source of NADPH and ribose
  • Oxidative (irreversible) reaction generates NADPH
  • Non oxidative (reversible) reaction generated Ribose 5 phosphate
  • all of the above
  • 1 and 2 only

Question 24

Question
All of the following are true about Reactive Oxygen Species
Answer
  • SOD, Catalase and Glutathione are all the enzymes that are used as a defense against oxygen toxicity
  • OH radicle attacks the C=C polyunsaturated lipid in membrane which yields malondialdehyde
  • Free radical production is part of host defense, intended to destroy microorganism and tumor cells
  • All of the above

Question 25

Question
Acetaminphen
Answer
  • Normal amounts of which are sulphated or glucuronated for excretion
  • Excess is oxidized by Cyp 2E1 to toxic NAPQI
  • NAPQI cannot be metabolized
  • N acetyl cysteine is the treatment for acetaminophen toxicity

Question 26

Question
Ethanol
Answer
  • Dehydrogenated to Acetaldehyde by ADH which is then dehydrogenated by ALDH to acetyl CoA
  • Pyruvate is converted to lactate to generate NAD+ which can be used in the above dehydrogenase reactions as Hydrogen acceptor
  • Lactic acidosis, gout, hypoglycemia and hyperlipidemia are all acute effects of ethanol metabolism
  • all of the above are correct
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