Question 1
Question
Vasopressin is released when
Answer
-
a. increased blood pressure
-
b. increased blood volume
-
c. increased osmotic pressure of blood and cerebrospinal fluid
-
d. decreased blood volume
-
e. decreased osmotic pressure of blood and cerebrospinal fluid
Question 2
Question
Growth factor stimulated by
Answer
-
a. hyperglycemia
-
b. hypoglycemia (L-Dopa i dopamine, a-adrenergic agonists, encephalins, vasopressin, Low FFA in blood)
-
c. stress and sleep (REM)
-
d. physical excercise
Question 3
Question
. identify factors reducing affinity of hemoglobin for oxygen
Question 4
Answer
-
a. has low specific heat and therefore is a good source of heat storage
-
b. it can pass easily through NA channels
-
c. good solvent because of its polarity
Question 5
Question
Simple diffusion:
Answer
-
a. protein can diffuse easily through membrane
-
b. depends on chemical gradient concentration
-
c. hydrophobic proteins cannot diffuse via membrane
Question 6
Question
Erythrocytes of newborn
Answer
-
a. contain immature hemoglobin that matures during first week after delivery
-
b. hemoglobin has higher affinity to oxygen
-
c. have small nucleus
-
d. contain less hemoglobin than mature erythrocytes
Question 7
Question
Agglutination of erythrocytes is in vitro phenomenon. Which of following processes may facilitate agglutination.
Answer
-
a. Cooling (decreasing of temp) of the in vitro preparation
-
b. Administration of immunoglobulins against human IgG (idea of indirect antiglobulin test/indirect Coombs test)
-
c. Enzymatic modification of molecules of the IgG immunoglobulins
-
d. Activation of the complete system performed by complexes antigen immunoglobulins IgM/IgG
Question 8
Question
In healthy humans which of the following morphological elements of peripheral blood have the shortest life span:
Question 9
Question
PCV (Packed Cell Volume) of the female is 20%. Identify right sentence concerning her case
Answer
-
a. Her RBC is approximately 3,5 mln/mm3
-
b. She is in state of dehydration
-
c. The client suffers because of anemia
-
d. The client is in a state of polycythemia
-
e. Her RBC is approximately 2,0 mln/mm3
Question 10
Question
Identify right statement concerning EPO:
Answer
-
a. 85% of erythrocytes comes from kidney and 15% from liver
-
b. it is synthesized in the kidney and next hydroxylated in liver in effect of hypoxia
-
c. Chemoattractant facilitates homing of blood progenitor cells in bone marrow
-
d. Bilaterally nephrectomized (removal of both kidneys) patients are able maintain proper erythropoiesis
-
e. EPO stimulates differentiation of erythrocytes from cells of Colony Forming Unit of Mixed Lineages
-
f. G-CSF and interleukins 3 stimulates differentiation of erythrocytes from Colony Forming Unit of Mixed-Lineages
Question 11
Question
Hematopoietic stem cells play key role in human organism. Identify right statement.
Answer
-
a. migrate among stem cell niches of embryo
-
b. possesses ability for self renewal, highly resistant to radio chemotherapy
-
c. HSCs are not able to differentiate into blood cells of lymphoid lineage
-
d. Migration of HSCs finishes after birth. Hematopoiesis is performed in axial skeleton + proximal parts of long bones -
Question 12
Question
Identify the right statement related to counting of leukocytes in hemocytometers (Such as Burker chamber):
Answer
-
a. Measurement of leukocytes requires previous hemolysis of erythrocytes
-
b. Fluids used for counting of leukocytes shrink erythrocytes
-
c. Fluids used for counting of leukocytes stain organelles of leukocytes
-
d. Counting of leukocytes requires previous staining of all blood cells
-
e. Hypertonic solution used for counting of leukocytes dilutes blood
Question 13
Question
Which of the following statements concerning sedimentation of erythrocytes are true
Answer
-
a. Assessment of ESR requires centrifugation of erythrocytes
-
b. Increase of globulins concentration and decrease of albumin concentration in plasma decreases aggregating ability of erythrocytes. Due to this reason ESR rises
-
c. Normal ESR in healthy adult humans is usually lower than 10 mm/hour
-
d. ESR increases during menstruation and after physical exercise
Question 14
Question
Which of the following statements concerning sedimentation of erythrocytes are true
Answer
-
Assessment of ESR requires centrifugation of erythrocytes
-
b. Increase of globulins concentration and decrease of albumin concentration in plasma increases aggregating ability of erythrocytes. Due to this reason ESR rises
-
d) ESR increases during menstruation and after physical exercise
Question 15
Question
Hemolysis of the normal erythrocyte can occur (find best answer):
Answer
-
a. in concentrated solution of urea
-
b. in isotonic solution of glucose
-
c. in distilled water
-
d. in effect of dehydration (water-loss)
-
e. in 0,5% saline
Question 16
Question
Which of following statement concerning erythrocytes are true:
Answer
-
a. RDW (red blood cell distribution width) is quantitative measure of MCV
-
b. MCV is an erythrocyte index expressing average volume of erythrocytes
-
c. C of hemoglobin in blood of healthy adult women ranges 12-16 g/dL
-
d. Standard erythrocyte due to its size + shape is not able to pass via capillaries which diameter is lower than 10 micrometer
Question 17
Question
Identify right statements concerning an antigen:
Answer
-
a. it is secreted by plasmocytes in effect of immune response
-
b. it is any substance which is able to induce specific immune-response
-
c. it is secreted by T-lymphocytes in effect of immune response
-
d. able to activate complement system when bound by APCs
Question 18
Question
Which of following statements may characterize basophiles of blood:
Answer
-
a. They have large, dark blue granules in their cytoplasm
-
b. they present antigens to immune competent cells
-
c. they account for 5-10% of all leukocytes of peripheral blood
-
d. their granules contain histamine, heparin and other chemicals involved in allergic and immune responses
Question 19
Question
Functions of ionized calcium in organism are:
Answer
-
a. it inhibits secretory processes
-
b. maintains proper functioning of cellular membrane transport
-
c. factor 4 of coagulation supports proper coagulation process
-
d. it modifies hemoglobin which reduces hemoglobin affinity for oxygen
Question 20
Question
Identify right statements concerning tetany:
Answer
-
a. high plasma of magnesium produces tetany
-
b. hypocalcemia produces tetany
-
c. tetany can be observed in people whose ventilation is depressed
-
d. tetany will be observed in people with elevated level of PTH in plasma
-
e. tetany can be observed in hyperventilating people
Question 21
Question
Which statement characterize IgG immunoglobulin
Answer
-
a. it can easily produce aggregation in standard environment of own plasma
-
b. it cannot pass through placenta
-
c. it can activate complement system
-
d. it has two antigen binding sites
-
e. it is a memory immunoglobulin
Question 22
Question
Which of following terms and definitions properly describes hemoglobin molecules able to perform their action in conditions in human organism:
Answer
-
a. methemoglobin which is a form of oxygenated hemoglobin present in lungs
-
b. carbaminohemoglobin, a form of deoxygenated hemoglobin bound by CO2
-
c. carbaminohemoglobin, a form of deoxygenated hemoglobin bound by CO
-
d. oxyhemoglobin, a form of oxygenated hemoglobin present in lungs
-
e. oxyhemoglobin, a form of oxidized hemoglobin dominating in erythrocytes of arterial blood
Question 23
Question
Identify factors reducing affinity of hemoglobin for oxygen in tissues
Answer
-
a. increases pO2 and decreases pCO2
-
b. increases concentration of 2,3 BPG in erythrocytes
-
c. decreases temp. + decreases C of glucose in hypoxic tissues
-
d. decreases pH of blood + increases-temp
Question 24
Question
Activated partial thromboplastin time (APTT):
Answer
-
a. it is prolonged in case of low plasma concentration of fibrinogen (Factor 1)
-
b. depends on processes of intrinsic pathway of coagulation
-
c. depends on platelets count
-
d. depends on state of vascular wall
Question 25
Question
Identify proper statement concerning plasma coagulation proteins
dependent on vitamin K:
Answer
-
a. they can be activated by heparin. substrates for thrombin
-
b. Post-translatory modification of molecules of prothrombin factor 2 + 10 in liver depends on vitamin K
-
c. activity is inhibited by inhibitors of cyclooxygenase
-
d. They are plasma coagulation factors 1, 5, 8
-
e. They are proteolytic enzymes (serine-proteases)
Question 26
Question
Identity proper statements concerning plasma coagulation proteins dependent on vitamin K
Answer
-
a) They can be activated by heparin
-
b) They are plasma coagulation factors II, VII, IX, X.
-
c) They are plasma coagulation factors I, V, VIII, XIII
-
d) Their activity is inhibited by inhibitors of cyclooxygenase
-
e) They are plasma coagulation factors XI, XII, HMWK -
-
Their activity is inhibited by coumarin-derivatives such as dikumarol and warfarin
Question 27
Question
Extrinsic pathway of coagulation
Answer
-
a. begins with exposure of collagen + activation of factor 7+3 coagulation -
-
b. begins with liberation of tissue thromboplastin (tissue factor (3))
-
c. requires factor 12 for full activation of hemostatic process
-
d. requires calcium ions (+ PL)
Question 28
Question
Find right sentences concerning hemagglutinins:
Answer
-
a. agglutinogens are synthesized in Rh+ individuals after exposure to Rh- blood
-
b. hemagglutinins in ABO system are mostly IgM class
-
c. hemagglutinins in ABO system are inborn
-
d. in ABO system they are synthesized after immunization against antigen A + B commonly present in environment
Question 29
Question
Type AB individuals have genes which code for
Answer
-
a. the sequence of amino acids of both A and B antigens
-
b. enzyme transferase that catalyzes placement of N-acetylgalactosamine into H antige
-
c. enzyme transferase that catalyzes placement of fucose onto A antigen
-
d. enzyme transferase that catalyzes placement of N-acetylgalactosamine onto D antige
-
e. enzyme transferase that catalyzes placement of D-galactose onto H antigen
Question 30
Question
A pregnant woman comes in for a visit. She is AB Rh-, her husband A Rh+. This is her first child. The indirect antiglobulin test is negative.
What should be done at the time of the first visit
Answer
-
nothing
-
a. nothing
b. administration of anti D-immunoglobulin to the mother at this time
-
c. administration of anti D-immunoglobulin to the mother after delivery
-
d. administration of anti D-immunoglobulin to the child if the child is Rh+
Question 31
Question
A couple requests blood typing of their child (father AB, mother B). Child erythrocytes are agglutinated by antigen B immunoglobulin, not agglutination by anti A or anti D) Child serum agglutinates A typed erythrocytes, does not agglutinate B typed erythrocytes. Which of following conclusions concerning child's blood type and child´s parentage:
Answer
-
a. the child is the natural offspring of this couple
-
b. the mother is natural, the father is not the natural father
-
c. the father is natural, the mother is not the natural mother
-
d. blood type in ABO-system is A
-
e. blood type in ABO-system is B
-
f. blood type in ABO-system is AB
-
g. child is Rh-
-
h. child is Rh+
Question 32
Question
Analyze ABO system of a couple: a woman (blood type A) has a
father whose blood type is O, and is married to a man whose blood type is B (his mother type is O). What is their child probability of blood type A:
Answer
-
a. 0 %
-
b. 25 %
-
c. 50 %
-
d. 75 %
Question 33
Question
Which of following statements about Vasopressin are right?
Answer
-
a. increases salt and water reabsorption in distal tubule
-
b. increases water reabsorption by insertion of protein of AQP2 in distal part of nephron
-
c. synthesized in posterior pituitary gland
-
d. produces vasoconstriction. Action is mediated receptors coupled with phospholipase C (PLC)
Question 34
Question
Growth hormone (GH)
Answer
-
a. Acts through receptor related to Janus kinase
-
b. Is a water soluble amine hormone
-
c. Is intensively liberated during NREM sleep
-
d. Elevates plasma level of glucose (+ FFA)
-
e. liberated from posterior pituitary gland
Question 35
Answer
-
a. produces contraction of myoepithelial cells of the female breast
-
b. increase secretion of prolactin (gonadotropins + thyrotropin)
-
c. it’s secretion is elevated by progesterone
-
d. is produces in paraventricular nucleus of hypothalamus
-
e. decreases contraction in vas deferens in males
Question 36
Question
inotropic receptor producing IPSP
Question 37
Question
Extracellular fluid (ECF)
Answer
-
a. Is approximately 20% of total body
-
b. is approximately 20% of body mass
-
c. its volume can be tested by intravenous infusion of insulin
-
d. its main cation is MG2+
Question 38
Question
Find features that characterize Ryanodine Receptors
Answer
-
A. They are Ca2+ channels in T-tubules
-
B. They are Ca2+ channels present in Sarcoplasmic Reticulum
-
C. They are Ca2+ pumps
-
D. They are gated by Ca2+
-
E. They are gated by IP3
Question 39
Question
Which of these sentences regarding Extra-cellular Fluid is true?
Question 40
Question
ECF is made up of which fluid compartments?
Answer
-
Blood plasma
-
Interstitial fluid
-
Intercellular fluid
-
Transitional fluid
Question 41
Question
Fast EPSP is due to
Question 42
Question 43
Answer
-
a. Voltage gated Cl- channel
-
b. Cl- channel, gated with GABA
-
c. Activation leads to IPSP
Question 44
Question
R- receptor (ryanodine receptor?)
Answer
-
Metabotropic receptor
-
Gated by Ca2+
-
Na+/Ca2+ exchanger
Question 45
Question
Receptors with tyrosine kinase
Answer
-
a. Muscarinic
-
b. EPO
-
c. insulin
-
d. growth hormone
Question 46
Question
Ionotropic receptors – which receptors belongs to this group?
Answer
-
• Nicotinic – Na+ (EC) (binds acetylcholine)
-
• GABAa – Cl- (EC)
-
• glycine – Cl- (EC)
-
• IP3 - Ca2+ (IC)
-
• Ryanodine - Ca2+ (IC)
-
• Cyclic nucleotide-gated ion channels- ligand cGMP, cAMP, cGTP (Na+, K+)- (IC)
-
• Intracellular ATP receptors - K+ (IC)
Question 47
Question
Which of the following statements concerning ionotropic receptors are true?
Answer
-
a. They are membrane receptors that open after binding their agonist ligand
-
b. examples are: nicotinic receptor and IP3 receptor
-
c. examples are muscarinic receptor + insulin receptor
-
d. they are located in cellular nucleus
Question 48
Question
Which of the following statements are related to nicotinic receptors?
Answer
-
a. Activation of nicotinic receptor produces IPSP of postsynaptic neuron
-
b. activation of nicotinic receptor produces EPSP of presynaptic knob
-
c. it is chemically gated sodium channel (Na)
-
d. nicotinic receptors activated by GABA
-
e. Acetylcholine is a natural gated ligand for the nicotinic receptor
Question 49
Question
Which of the following statements concerning intracellular fluid are true?
Answer
-
a. ICF is approximately 20% of Body mass
-
b. ICF is app. 2/3 of the TBW in healthy, non obese humans.
-
c. its main anion is bicarbonate HCO3
-
d. its main kation is K+
-
e. volume of ICF can be tested by intravenous infusion of insulin
Question 50
Question
Identify basic principles concerning counting of leukocytes:
Answer
-
a. hypertonic solution used for counting of leukocytes dilutes blood
-
b. counting of leukocytes requires previous hemolysis of erythrocytes
-
d. fluid usually used for assessment of WBC shrinks erythrocytes
-
e. fluid usually used for assessment of WBC stains organelles of leukocytes
Question 51
Answer
-
a. Agglutinins are present in plasma of adults
-
b. Agglutinins are inherited proteins located on membranes of erythrocytes
-
c. Agglutinogens are present in plasma of neonates (newborns)
-
d. Antigens of the AB0 are found in various tissues
Question 52
Question
Hemolysis of normal erys occurs:
Answer
-
a. in effect of action of strong inorganic acids in organic solvents
-
b. in temperature higher than 60 °C
-
c. in 5% solution of Glucose -
-
d. in distilled water
-
e. in 0,6 saline
Question 53
Question
Choose the correct statements concerning B-lymphocytes:
Answer
-
a. these cells play role in cellular immunity
-
b. they mediate humoral immunity
-
c. they develop entirely in bone marrow
-
d. in effect of antigenic stimulation they form plasma cells which secrete immunoglobulins
Question 54
Question
Choose correct sequence of the following processes involved in inflammatory response:
(ANSWER IN EXPLANATION)
Answer
-
a. chemotaxis
-
b. rolling
-
c. diapedesis
-
d. adhesion
Question 55
Question
Match properly in pairs:
(answer in explanation)
Answer
-
Isovolemia
-
Isohydria
-
Isotonia
Question 56
Question
Which of following statements concerning simple diffusion via cellular membrane are true?
Answer
-
a. it depends on the ability of the molecule to dissolve in lipids
-
b. it depends on the chemical gradient
-
c. its rate of diffusion is directly proportional to surface area and inversely proportional to molecular size and thickness of membrane
-
d. requires special carrier proteins
Question 57
Question
Thrombin dependant (hydrolyzed by thrombin) coagulation factors are:
Answer
-
a. Factor 2 (Prothrombin)
-
b. Fibrinogen
-
c. Factors 4,5,8,13
-
d. Factor 8 (fibrin stabilizing factor)
-
e. high molecular weight kininogen (HmWK)
Question 58
Question
Identify right statements concerning Prothrombin time – in vitro laboratory time of coagulation:
Answer
-
a. is prolonged in treatment with antivitamin K (and diseases of liver)
-
b. depends on processes of intrinsic pathway of coagulation
-
c. depends on processes of extrinsic pathway
-
d. depends on platelets count (number of platelets)
-
e. depends on state of vascular endothelium
Question 59
Question
Affinity of hemoglobin for oxygen increases in case of:
Answer
-
a. decreasing PO2 in plasma (hypoxia)
-
b. decreasing PH in Plasma (acidosis)
-
c. decreasing PCO2 in plasma
-
d. decrease in temperature
-
e. increasing PH in plasma (alkalosis)
Question 60
Question
Which of the following statements are true in case of Erythropoietin (EPO)?
Answer
-
a. a glycoprotein which controls production of erythrocytes
-
b. it is made mostly in liver
-
c. hypoxia is the main stimulus for EPO release
-
d. Adenosine antagonist stimulates secretion of EPO
Question 61
Question
Identify right statements concerning receptors for hormones:
Answer
-
a. Angiotensin AT1 – receptor is coupled with phospholipase C
-
b. Receptors coupled with Gs protein activate phosphodiesterase (PDE)
-
c. Epinephrine produces its intracellular effect decreasing of adenylyl cyclase
-
d. receptors for thyroid hormones are placed in plasma membrane
-
e. receptors for sex hormones possess DNA binding domains, there are transcription factors
Question 62
Question
Ionotropic receptor producing IPSP is:
Question 63
Question
Growth hormone (GH)
Answer
-
a. acts through receptor related to Janus kinase
-
b. Is a water soluble amine hormone
-
c. is intensively liberated during NREM sleep
-
d. Elevates plasma level of glucose
-
e. is liberated from posterior pituitary gland
Question 64
Answer
-
a. produces contractions of myoepithelial cells of female breast
-
b. increases secretion of prolactin
-
c. secretion is elevated by the progesterone
-
d. Is produced in paraventricular nucleus of hypothalamus
-
e. Decreases contraction in vas deferens in males
Question 65
Question
Functions of ionized calcium in organism are:
Answer
-
a. It maintains proper functioning of neurons and myocytes
-
b. It maintains proper functioning of membranes (trans-membrane transport)
-
c. It is factor II of coagulation, supporting proper coagulation process
-
d. It binds hemoglobin, reducing hemoglobin affinity to oxygen
Question 66
Question
Choose the correct statement concerning chemotaxis:
Answer
-
a. movement/passage of blood cells, especially leukocytes, via intact capillary wall into interstitial space inflamed area
-
b. it is the movement of neutrophils and macrophages toward the source of some particular chemical substance.
-
c. It is a process which Is performed down concentration gradient of a chemotactic substance
-
d. It may be caused by the bacterial and viral toxins, degenerative products of the inflamed tissues and lymphokines.
Question 67
Answer
-
a. produces contractions of myoepithelial cells of the female breast
-
b. is produced in the medulla oblongata
-
c. is liberated in effect of stimulation of mechanoreceptors in the uterine cervix
-
d. Produces relaxation of smooth muscle cells of most of vessels
Question 68
Question
Which of the following are NOT secreted by the anterior pituitary gland?
Answer
-
a. Vasopressin, Calcitonin
-
b. GH, TSH
-
c. TRH,PIH parathyroid hormone
-
d. Prolactin, gonadotropins
Question 69
Question
In neuromuscular junction you can find:
Answer
-
a. N-Cholinergic receptor
-
b. Acetylcholine receptor
-
c. B-Adrenergic receptor
-
d. Folds of cardiac membrane
Question 70
Question
Factors that stimulate growth hormone (GH, somatotropin) release are:
Question 71
Question
The following actions produces by vitamin D3
Answer
-
a. Stimulated synthesis of calcitonin in intestine -
-
b. increases number and activity of osteoclasts and osteoblasts
-
c. ---ocytes, it up-regulates activity of cytosolic enzymes of and increases concentration of calcium binding…rising absorption of calcium ion from the lumen of intestine
-
d. Increases reabsorption of calcium and phosphate in kidney
Question 72
Question
Find right sentences concerning erythrocytes sedimentation rate (ESR):
Answer
-
a. It is proportionate to plasma concentration of globulins
-
b. It should not exceed 15 mm/h in healthy adults. It is much higher in infectious diseases and cancer
-
c. It is a ratio of volume of all erythrocytes to the volume of whole blood
-
d. It decreases after heavy meals and physical exercise
Question 73
Question
Find proper sentences concerning transportation of CO2 in blood:
Answer
-
a. Only 5-7% of CO2 is transported in dissolved form in blood
-
b. More than 70% of CO2 is converted in bicarbonate in plasma of blood
-
c. Bicarbonate is formed from carbonic acid. Reaction is catalyzed by carbonic anhydrase of erythrocytes
-
d. Part of CO2 is reversibly bound to hemoglobin, forming carboxy- and methemoglobin
-
e. Carbaminohemoglobin is an example of reduced hemoglobin of red-brown colour
Question 74
Question
Low level of PCV may result from:
Answer
-
a. Hemorrhage
-
b. Anemia
-
c. Dehydration
-
d. Repetitive exercise
Question 75
Question
Identify statements characteristic for “0” typed individuals in AB0 system:
Answer
-
a. They have gene/genes coding for the sequence amino acids of fucosyltransferase
-
b. They have no antigens on membranes of erythrocytes
-
c. Both anti-A and anti-B immunoglobulins are synthesized after exposition to those antigens
-
d. Both anti-A and anti-B hemagglutinins are present in their plasma since their birth
Question 76
Question
Identify right statements concerning the clotting time:
Answer
-
a. It is prolonged in people treated with heparin (afibrinogenemia, factors 2,5,9,10,11,12)
-
b. It depends in the number of platelets
-
c. It tests processes of intrinsic pathway of coagulation
-
d. It depends on the state of the vascular wall
Question 77
Question
Primary Hemostasis:
Answer
-
a. Depend on the equilibrium between plasma coagulation proteins and blood vessel
-
b. It tested by clotting time and APTT
-
c. Is tested by bleeding time
-
d. Is prolonged in individuals treated with inhibitors of cyclooxygenases (aspirin)
Question 78
Question
Identify factors dealing with Vasopressin release:
Answer
-
A. Increased Osmotic Pressure, Blood and Cerebrospinal Fluid
-
B. Increased Blood Volume
-
C. Decreased Osmotic Pressure, Blood and Cerebrospinal Fluid
-
D. Decreased Blood Volume
-
E. Increased Blood Pressure
Question 79
Question
Phenomenon of increased liberation of renin
Answer
-
a. increased arterial pressure
-
b. hypoperfusion of kidney
-
c. decreased Nacl in the area of the macula densa
-
d. Activation of sympathetic system
Question 80
Question
Identify statements related to Türk ́s solution used in hemocytometer (counting of blood cells):
Answer
-
a. It produces hemolysis of erythrocytes.
-
b. It shrinks erythrocytes
-
c. It stains organelles of leukocytes.
-
d. It stains erythrocytes.
-
e. It dilutes blood.
Question 81
Question
Tetany can be observed in:
Answer
-
a. Low plasma level of magnesium.
-
b. High plasma level of calcium
-
c. High plasma level of calcium. And H^+
-
d. Acidosis (low pH)
-
e. Alkalosis (high pH)
Question 82
Question
Hypercalcemic hormones (elevating calcium level in plasma) are:
Question 83
Question
Identify forms of CO2 transported in blood
Question 84
Question
Erythrocyte sedimentation rate (ESR):
Answer
-
a) Is a part of the blood volume that is occupied by erythrocytes
-
b) Increases with increasing concentration of plasma globulins. (ratio of albumin/globulin)
-
c) Is proportionate to RBC (number of erythrocytes in blood)
-
d) Increases with decreasing volume of erythrocytes (MCV).
Question 85
Answer
-
a) Agglutinin are inherited proteins located on membranes of erythrocytes.
-
b) Agglutinins are present in plasma of neonates (newborn)
-
c) Antigens are found in various tissues in addition to blood.
-
d) Agglutinins are present in plasma of adults.
Question 86
Question
Identify statements characteristic for 0 type individuals:
Answer
-
a. Antigens H are present on erythrocytes.
-
b. Antigens A are present on erythrocytes.
-
c). Antigens B are present on erythrocytes.
-
d) Both anti-A and anti-B hemagglutinines are present in plasma.
Question 87
Question
In Rh system of blood:
Answer
-
a) D antigen is the most antigenic (strongest) component of the system.
-
b) D antigen is the only antigen of the system
-
c) Antigens are proteins located only on membranes of erythrocytes.
-
d) Agglutinogens are synthesized in Rh-positive individuals after exposure to Rh-negative blood.
Question 88
Question
Which statements characterize MHC-II proteins?
Answer
-
They are found on all nucleated cells, dendritic, macrophages, b-lymphocytes
-
b) They are found on antigen presenting cells
-
c) They are bound by cytotoxic T-lymphocytes
-
d) They are bound by helper T-lymphocytes
Question 89
Question
Main action of complement components are:
Answer
-
a) Damage of the cellular membrane followed by cellular lysis.
-
b) Increase of the vascular permeability and smooth muscle contraction
-
c) Chemotaxis and chemokinesis of the macrophages and neutrophils.
-
d) Phagocytosis performed by NK-cells
-
e) Degranulation of mast cells and basophils
-
f) Opsonization (facilitate phagocytosis)
Question 90
Question
Cells of the peripheral blood able to perform phagocytosis are:
Answer
-
a) Lymphocytes
-
b) Neutrophils
-
c) Basophils
-
d) Eosinophils
-
e) Megakarocytes
Question 91
Question
So called passive immunity develops after:
Answer
-
a) Invasion of a pathogen and development of the disease
-
b) Vaccination with separated antigens of microbes
-
c) Passage of maternal immunoglobulins through placenta, with milk or colostrum
-
d) Parenteral administration of the ready-made immunoglobulins
Question 92
Question
So called contact factors of coagulation are
Answer
-
a. Plasma coagulation factors II, VII, IX, X, C-protein, S protein
-
b. Plasma coagulation factors I, V, VIII, XIII
-
c. HMWK, prekallikrein
-
d. Plasma coagulation factors XI, XII
Question 93
Question
Primary hemostasis is composed of
Answer
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a. Activation of plasma coagulation factors X, II and I
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b. Agglutination and coagulation of platelets
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c. Contraction of the damaged vessel
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d. Adhesion, activation, aggregation and granulation of platelets
Question 94
Question
Extrinsic pathway of coagulation
Answer
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a. Begins with exposure of collagen + activation of factor XII of coagulation
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b. Begins with liberation of tissue thromboplastin (tissue factor)
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c. Runs faster than intrinsic pathway
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d. Requires calcium ions
Question 95
Question
Anti-inflammatory action of glucocorticoids are
Answer
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a. They inhibit penetration of plasma proteins and inflammatory mediators through the vessel wall
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b. They decrease the number of basophils, eosinophils, and lymphocytes
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c. They decrease the number of neutrophils
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d. All answers are wrong.
Question 96
Question
What are the main functions of SDF-1 in human hematopoiesis?
Answer
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a. It is a stem cell homing factors involved in the movement of hematopoietic cells from........... hematopoiesis) -
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b. It is a hematopoietic factor that acts at different stages of stem cell differentiation
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c. This protein mostly regulates proliferation of stem and progenitor cells during.....??!
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d. This factor enables the homing of transfused stem cells in the bone marrow..
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e. Specifically interacts with superficial stem cell receptor – CXCRA
Question 97
Question
Hypocalcemic hormones (decreasing calcium level in plasma) are:
Answer
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a. PTH
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b. Calcitonin
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c. Glucocorticoid Steroids
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c. Glucocorticoid Steroids.
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d. Vitamin 1,25 (OH)2 D3 + thyroid hormones, GH
Question 98
Question
Tetany can be observed in:
Answer
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a. Low plasma level of potassium
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b. High plasma level of potassium.
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c. High plasma level of HCO3^-
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d. Acidosis
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e) High plasma level of HPO4^-.
Question 99
Question
So called active immunity develops after
Answer
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a. After natural invasion of a pathogen and development of the response
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b. Vaccination with separated antigens of microbes
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c. Parenteral administration of ready-made immunoglobulins
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d. Passage of maternal immunoglobulins via placenta, with milk or colostrum
Question 100
Question
Identify statements related to Hayem’s solution used in hemocytometer (counting of blood cells):
Answer
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a. It produces hemolysis of erythrocytes.
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b. It shrinks erythrocytes.
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c. It stains organelles of leukocytes
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d. It stains erythrocytes.
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e. It dilutes blood.
Question 101
Question
Which of the following statements concerning water in human organism are true:
Answer
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a. Water characterises with extremely high specific heat
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b. It is a natural solvent and environment for all physiological and chemical processes occurring in human organism
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c. Aldosterone directly increases water reabsorption in collecting duct
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d. Main cation of intracellular water compartment is magnesium, main anion dicarbonate
Question 102
Question
Identify right statements concerning Total Body Water (TBW)
Answer
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a. Its volume can’t be assessed by intravenous injection of inulin or other colloid molecule -
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b. Majority of water of TBW fills extracellular compartment of organism
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c. It is usually 60% of the body weight of the young adult human and it tends to decrease with age
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d. Water can easily pass through cellular membrane via common to all cells water channel – aquaporin AQP1
Question 103
Question
Factors that stimulate growth hormone (GH, somatotropin) release are:
Answer
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a. GnRH liberated from hypothalamus
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b. Hyperglycemia
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c. Decreased concentration of free fatty acids and glucose in plasma (Hypoglycemia)
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d. Physical exercise - sleep, Dopamines
Question 104
Question
Which of the following statement concerning oxytocin are true:
Answer
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a. Peptide hormone synthesized in anterior pituitary gland
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b. Its liberation is inhibited by stimulation of mechanoreceptors located in cervix of the uterus
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c. Responsible for milk ejection in effect of contraction of myoepithelial cells
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d. Produces contraction of smooth muscle cells of the pregnant and non-pregnant uterus
Question 105
Question
Which of the following statements concerning affinity of hemoglobin for oxygen are true:
Answer
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a. Affinity is inversely proportional to pH
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b. Affinity is proportionate to the body temperature
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c. Product of glycolysis in erythrocytes – 2,3 BPG decreases affinity of hemoglobulin for oxygen
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d. High partial pressure of carbon dioxide – pCO2in plasma decreases affinity of hemoglobin for oxygen
Question 106
Question
Find right sentences concerning erythrocytes sedimentation rate (ESR):
Answer
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a. It is proportionate to plasma concentration of globulins
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b. It should not exceed 15 mm/h in healthy adults. It is much higher in infectious diseases and cancer
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c. It is a ratio of volume of all erythrocytes to the volume of the whole blood
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d. It decreases after heavy meals and physical exercise
Question 107
Question
Find proper sentences concerning transportation of CO2 in blood:
Answer
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a. Only 5-7% of CO2 is transported in dissolved from in blood
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b. More than 70% of CO2 is converted in bicarbonate in plasma of blood
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c. Bicarbonate is formed from carbonic acid. Reaction is catalyzed by carbonic anhydrase of erythrocytes
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d. Part of CO2 is reversibly bound to hemoglobin, forming carboxy- and methemoglobin
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e. Carbaminohemoglobin is an example of reduced hemoglobin of red-brown colour
Question 108
Question
Low level of PCV may result from:
Question 109
Question
Identify statements characteristic for “0” typed individuals in AB0 system:
Answer
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a. They have gene/genes coding for the sequence amino acids of fucosyl-transferase
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b. They have no antigens on membranes of erythrocytes -
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c. Both anti-A and anti-B immunoglobulins are synthesized after exposition to those antigens
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d. Both anti-A and anti-B hemagglutinins are present in their plasma since their birth
Question 110
Question
Find solutions able to produce hemolysis to normal erythrocytes:
Answer
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a. Hypertonic solution of glucose
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b. Organic solvents (soap, detergents, etc)
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c. Distilled water
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d. Hypertonic solution of sodium chloride
Question 111
Question
Haemolytic Newborn disease can cause:
Question 112
Question
Choose the correct statement concerning B-lymphocytes
Answer
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a. They are mediators of humoral immunity
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b. They are formed mainly in thymus
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c. In effect of antigenic stimulation they form plasma cells which secrete immunoglobulins
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d. They mediate cellular immunity
Question 113
Question
Functions of ionized calcium in organism are:
Answer
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a) It maintains proper functioning of neurons and myocytes.
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b) It maintains proper functioning of the cellular membranes (trans-membrane transport)
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c) It is factor IV of coagulation supporting proper coagulation process.
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d) It binds hemoglobin reducing hemoglobin affinity to oxygen.
Question 114
Question
Packed cell volume or hematocrit (PCV or Hct):
Answer
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a) Is a part of blood volume that is occupied by erythrocytes
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b) Is significantly lower in individuals treated with aspirin
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c) Is inversely proportional to RBC (number of erythrocytes in blood).
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d) Is proportionate to the volume of erythrocytes (MCV).
Question 115
Question
Biological effects of calcitonin are:
Answer
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a) Low plasma calcium level
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b) High plasma calcium level
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c) Low plasma phosphate level
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d) High plasma phosphate level
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e) Increased excretion of calcium and phosphate through kidneys
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f) Decreased excretion of calcium and phosphate through kidneys
Question 116
Question
Actions of vitamin D3 (cholecalciferol) are
Answer
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a) It increases reabsorption of Ca 2, from intestines
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b) It decreases reabsorption of Ca 2, from intestines
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c) It increases reabsorption of Ca 2, from the nephron tubule
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d) It decreases reabsorption of Ca 2, from the nephron tubule
Question 117
Answer
-
a) Against antigens of Rh system develop in childhood
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b) In ABO system are mainly of IgM class.
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c) In ABO system are inborn
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d) In ABO system are synthesized after immunization with antigens A and B commonly present in environment.
Question 118
Question
Find agents able to produce hemolysis to normal erythrocytes
Question 119
Question
Find the most specific features of the ECF:
Answer
-
a. Concentration of the Na = ion range 135-145 mEq/L
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b. Concentration of the Cl- range 3,5-5 mEq/ L
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c. Most of water of ECF is located in plasma of blood. Volume of ECF is approximately 5,0
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d. Concentration of proteins in interstitial fluid is lower than plasma of blood
Question 120
Question
Identify correct statements concerning human blood types:
Answer
-
a. 35% of caucasians and most africans are Rh negative
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b. The indirect antiglobulin test is used to detect immunoglobulins coating / binding erythrocytes
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c. Blood type B has gene coding for the sequence of amino acid of the B- antigen of their erythrocytes
-
d. humans with type 0 in ABO system possess antigen H located in membranes of their erythrocytes
-
e. the maximum concentration of immunoglobulins in ABO system is observed at birth -
Question 121
Question
Identify right statements related to vitamin D3 :
Answer
-
a. it stimulates synthesis of calcium binding protein (CBP) in intestines
-
b. its final active form is produced by the enzymatic process of 25- hydroxylation in liver
-
c. its final active form is produced by the enzymatic process of 1 alpha- hydroxylation in kidneys
-
d. it originates from 7- dehydroaldosterone treated with ultraviolet rays in skin
Question 122
Question
. Which statements characterize IgM immunoglobulin?
Answer
-
a. it can easily produce aggregation of erythrocytes in environment of own plasma
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b. it has two antigen- binding sites
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c. it is a memory immunoglobulin
-
d. it is not able to cross blood - placenta barrier
-
e. it can bind complement
-
f. it is commonly found in fetal blood: it is called natural or inborn immunoglobulin
Question 123
Question
Factors that produce hemolysis
Question 124
Question
Intracellular receptors are
Answer
-
a. IP3
-
b. GABA
-
c. ryanodine
-
d. dhp
-
e. m3
Question 125
Question
. Complement system
Answer
-
a. Induces cell membrane Lysis via membrane Attack complex (MAC)
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b. Induced by IgG
-
c. Leads to faster phagocytosis by macrophages
-
d. Increase vascular permeability
-
e. C5a leads to increased Chemotaxis
Question 126
Question
Hemolysis of normal erythrocytes occurs:
Answer
-
a. In high pH (alkalosis)
-
b. In temperature higher than 60°C.
-
c. In 5.0% solution of glucose
-
d. In distilled water.
-
e. In 0.2% saline
Question 127
Question
In B- typed individual, antigen B is generated from H antigen due to activity of
Answer
-
a. N-acetylogalatktoaminyl transferase catalyzing attachment of N-acetylogalactotiamine to H antigen
-
b. D-galactosyl transferase catalyzing attachment of isomaltose to H antigen
-
c. Fucose transferase catalyzing attachment of fucose to H antigen
-
d. D-galactose transferase catalyzes attachment of D galactose to D antigen
-
e. all ansers are incorrect