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Antihelminths/Antibacterials/Antifungal/Antiviral/Antimicrobial Susceptibility Testing

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Let's f*cking do this
Zainab Hassoun
Quiz by Zainab Hassoun, updated more than 1 year ago
Zainab Hassoun
Created by Zainab Hassoun about 9 years ago
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Question 1

Question
Select all that apply. Which of the following are β-lactamase penicillins?
Answer
  • Ampicillin
  • Ticarcillin
  • Methicillin
  • Piperacillin
  • Nafcillin
  • Amoxicillin

Question 2

Question
What does PBP1A bind to?
Answer
  • Transpeptidase
  • Carboxypeptidase
  • Endopeptidase

Question 3

Question
Penicillin G is stable in gastric acid.
Answer
  • True
  • False

Question 4

Question
Which of the following penicillins have rapid elimination times less than or equal to 90 minutes?
Answer
  • Penicillin G
  • Nafcillin
  • Ampicillin
  • Piperacillin
  • Amoxicillin
  • All of the above

Question 5

Question
One RARE side effect of Penicillin G K+ is [blank_start]_______________[blank_end].
Answer
  • hyperkalemia

Question 6

Question
Select all that apply. The mechanism of action for penicillins are:
Answer
  • concentration dependent bactericidal action
  • time dependent bactericidal action
  • works best against rapidly dividing bacteria
  • works best against slowly dividing bacteria
  • inhibits transpeptidase activity of PBP3

Question 7

Question
Which of the following cause neutropenia?
Answer
  • Penicillin V
  • Piperacillin
  • Penicillin G
  • Amoxicillin-Clavulanic Acid Combo
  • Vancomycin
  • A, B, and D
  • A and C
  • B, C, and E

Question 8

Question
Which of the following is the correct mechanism for how Polymyxins act as antibiotics?
Answer
  • Binds to ribosome 30s to prohibit protein synthesis
  • Disrupts the integrity of the baceterial cell wall by displacing calcium and magnesium
  • Inhibits the cross-linkages between the peptidoglycan polymer strands
  • Disrupts the integrity of the cell membrane by displacing calcium and magnesium

Question 9

Question
Which bacteria are susceptible to enzyme inactivation by beta lactamases?
Answer
  • Cephalosporins
  • Macrolides
  • Metronidazole
  • Tetracyclines

Question 10

Question
Penicillins are narrow spectrum drugs
Answer
  • True
  • False

Question 11

Question
Select all of the bactericidal antibiotics.
Answer
  • Macrolides
  • Penicillin
  • Tetracycline
  • Cephalexin
  • Aminoglycosides
  • Clindamycin

Question 12

Question
Which of the following is NOT a concern of antibiotic (antibacterial specifcially) use?
Answer
  • Stevens Johnsons
  • Superinfection
  • Teratology
  • Increased effects of oral contraceptives

Question 13

Question
Which of the following is incorrect regarding Penicillin G/Penicillin V
Answer
  • Used for mixed aerobic-anaerobic infections
  • Used against gram positive and gram negative bacteria
  • One of these two can be used for treatment of Rheumatic fever
  • These are all correct

Question 14

Question
Which of the following is not an antistaphylococcal penicillin?
Answer
  • Amoxicillin
  • Methicillin
  • Nafcillin
  • These are all antistaphylococcal penicillins

Question 15

Question
Penicillins work by inhibiting with enzyme?
Answer
  • Integrase
  • Peptidyl transferase
  • Transpeptidase
  • Transcriptase

Question 16

Question
Penicillin V is administered by IV only
Answer
  • True
  • False

Question 17

Question
Which of the following is NOT a possible adverse effect from penicillins?
Answer
  • Allergy
  • Phlebitis
  • Fungal overgrowth
  • Hemolytic anemia

Question 18

Question
Which of the following is true regarding aminopenicillins?
Answer
  • Resistant to beta lactamases
  • Narrow spectrum
  • Ampicillin has less side effects than amoxicillin
  • Effective against gonorrhea and meningitis

Question 19

Question
Select the following that are ineffective against beta lactamases:
Answer
  • Penicillin V
  • Penicillin G
  • Dicloxacillin
  • Amoxicillin

Question 20

Question
Which of the following best represents first generation cephalosporins?
Answer
  • Includes Cefotaxime and Ceftriaxone
  • Used for UTI (urinary tract infections) and soft tissue abscesses
  • Effective against Klebsiella and H influenza
  • Used for treatment of community-acquired pneumonia

Question 21

Question
Which of the following best describes the second generation of cephalosporins?
Answer
  • Drug of choice for surgical prophylaxis
  • Used to treat meningitis
  • Includes the drug Cefuroxime
  • Includes the drug Cefepime

Question 22

Question
Protein synthesis inhibitors are considered narrow spectrum antibiotics
Answer
  • True
  • False

Question 23

Question
Tetracyclines are broad spectrum antibiotics
Answer
  • True
  • False

Question 24

Question
Which of the following best matches the mechanism of tetracyclines?
Answer
  • Inhibition of beta 1-3 glycan of bacterial cell wall, preventing cross linkages
  • Becomes mechanically reduced to toxic metabolite, interacting with DNA
  • Binds to 50s subunit, preventing binding of tRNA to mRNA
  • Binds to 30s subunit, preventing binding of tRNA to mRNA

Question 25

Question
Which of the following are targeted by tetracyclines?
Answer
  • Rickettsia
  • MRSA infections
  • P. vivax malaria
  • All are targeted by tetracyclines

Question 26

Question
Which of the following is INCORRECT regarding macrolides?
Answer
  • Broad spectrum
  • Used as an alternative for patients allergic to penicillins
  • Can be bacteriostatic or bacteriocidal, depending on dose (concentration)
  • Kills gram positive and gram negative bacteria

Question 27

Question
Which of the following is incorrect regarding Chloramphenicol?
Answer
  • It is bacteriostatic
  • Binds to 50s ribosome
  • Can be used to treat typhoid fever
  • Can be used for Neisseria gonorrhea

Question 28

Question
Chloramphenicol can cause gray baby syndrome.
Answer
  • True
  • False

Question 29

Question
Which of the following is NOT a use for Clindamycin?
Answer
  • Pseudomembranous colitis
  • Anthrax
  • Toxic shock syndrome
  • Odontogenic infection

Question 30

Question
Which of the following is NOT a concern for use of Clindamycin?
Answer
  • Neuromuscular block
  • Skin rashes
  • Pseudomembranous colitis
  • Fulminant hepatic necrosis

Question 31

Question
What is the clinical use of sulfonamides?
Answer
  • Skin infections
  • UTI (urinary tract infections)
  • Alternative for patients allergic to penicillins
  • Pseudomembranous colitis

Question 32

Question
Sulfonamide is a structural analog of DFHR
Answer
  • True
  • False

Question 33

Question
Sulfonamides can cause which of the following adverse effects?
Answer
  • Photosensitivity
  • Pseudomembranous colitis
  • Neutropenia
  • Seizures

Question 34

Question
Clotrimazole can be used for UTI (urinary tract infections)
Answer
  • True
  • False

Question 35

Question
How do fluoroquinolones kill bacteria?
Answer
  • They bind to topoisomerase-DNA complexes and form an inactive complex
  • They bind to bacterial ribosomes 30s
  • They inhibit transpeptidases
  • They compromise the integrity of the bacterial cell membrane

Question 36

Question
Which of the following can cause Red Man Syndrome?
Answer
  • Penicillin
  • Erythromycin
  • Vancomycin
  • Sulfamethoxazole

Question 37

Question
Which of the following is NOT a side effect of drugs such as gentamicin, tobramycin, and amikacin?
Answer
  • nephrotoxicity
  • vestibular toxicity
  • tooth discoloration
  • cochlear toxicity

Question 38

Question
Which of the following cannot be used to treatment of MRSA?
Answer
  • Linezolid
  • Vancomycin
  • Streptogramins
  • Clindamycin

Question 39

Question
MRSA is resistant to ALL penicillins and cephalosporins
Answer
  • True
  • False

Question 40

Question
Which of the following does NOT increase risk of nephrotoxicity?
Answer
  • Aminoglycosides
  • Amphoterecin B
  • Cisplatin
  • Macrolides

Question 41

Question
Nystatin is not related to Amphoterecin B and can therefore be used systemically.
Answer
  • True
  • False

Question 42

Question
What type of fungal infection does nystatin treat?
Answer
  • Cryptococcal meningitis
  • Candida infections
  • Histoplasmosis
  • Asperillosis

Question 43

Question
Choose all of the trizoles.
Answer
  • Ketoconazole
  • Itraconazole
  • Fluconazole
  • Voriconazole
  • Miconazole
  • Clotrimazole.

Question 44

Question
What is the correct mechanism of azoles?
Answer
  • Disrupts microtubule function and inhibits dermatophyte growth
  • Binds to membrane Ergosterol
  • Inhibits viral DNA polymerase
  • Inhibits the lanosterol 14 alpha enzyme, preventing the conversion of lanosterol to ergosterol and disrupts the struction of fungal membrane

Question 45

Question
Which of the following is NOT an adverse effect of Azoles
Answer
  • Steven Johnson
  • Increased levels of warfarin
  • Decreased fluconazole levels with isoniazid
  • Nephrotoxicity

Question 46

Question
Which of the following antifungals are used to disrupt microtubule (spindle) function?
Answer
  • Terbinafine
  • Griseofulvin
  • Echinocandins
  • Ketoconazole

Question 47

Question
Which of the following antifungals is used for onychomychosis and tinea?
Answer
  • Griseofulvin
  • Terbinafine
  • Echinocandins
  • Ketoconazole

Question 48

Question
Which antiviral drug prevents formation of DNA chain by inhibiting viral DNA synthesis?
Answer
  • Acyclovir
  • Ganciclovir
  • Raltegravir
  • Retrovir

Question 49

Question
Ganciclovir causes myelosuppression
Answer
  • True
  • False

Question 50

Question
What is the therapeutic use for Penicillin?
Answer
  • Drug of choice for streptococci, pneumococcal, and staphylococcal infections
  • Treat infections due to bacteria that have developed resistance to earlier generations of cephalosporins
  • Treatment of a broad range of gram positive and gram negative organisms
  • Treatment of patients who are unable to tolerate penicillins

Question 51

Question
What is the pharmacological class for Penicillin G?
Answer
  • Aminoglycoside, protein synthesis inhibitor
  • Fluroquinolone, bacterial DNA synthesis inhibitor
  • Natural penicillin, cell wall inhibitor, beta lactam
  • Mycolic acid inhibitor

Question 52

Question
What is the pharmacological class of Cefotaxime?
Answer
  • Beta lactam antibiotic, cell wall inhibitor
  • Tetracycline, protein synthesis inhibitor
  • Macrolide, protein synthesis inhibitor

Question 53

Question
Mechanism of action for Cefotaxime?
Answer
  • Inhibits cell wall synthesis
  • Inhibits bacterial protein synthesis and prevents replication
  • Inhibits synthesis of mycolic acid

Question 54

Question
Tetracycline mechanism of action?
Answer
  • Inhibits bacterial protein synthesis and prevents cell replication
  • Inhibits bacterial gyrase
  • Inhibits cell wall synthesis

Question 55

Question
What is the pharmacologic class for erythromycin?
Answer
  • Macrolide, protein synthesis inhibitor
  • Aminoglycoside, protein synthesis inhibitor
  • Beta lactam antibiotic

Question 56

Question
What is the mechanism of action for erythromycin?
Answer
  • Inhibits protein synthesis
  • Inhibits cell wall synthesis
  • Binds to peptidoglycan
  • Inhibits bacterial protein synthesis and prevents cell replication

Question 57

Question
What is the pharmacologic class for gentamicin?
Answer
  • Fluoroquinolone
  • Sulfonamide, folic acid inhibitor
  • Aminoglycoside, protein synthesis inhibitor
  • Mycolic acid inhibitor

Question 58

Question
What is the mechanism of action for Gentamicin?
Answer
  • Inhibits bacterial metabolism of folic acid
  • Inhibits protein synthesis, disrupting cell membrane and killing bacteria
  • Inhibits synthesis of mycolic acids
  • Inhibits bacterial DNA gyrase, interfering with bacterial replication and DNA error

Question 59

Question
Which of the following drugs would be used as treatment of UTI, GI, STDs, soft tissue, bone and joint infections?
Answer
  • Trimetoprim-sulfamethoxazole
  • Ciprofloxacin
  • Isoniazid
  • Gentamicin

Question 60

Question
What is the pharmacological class and mechanism of action for ciprofloxacin?
Answer
  • Fluoroquinolone, inhibits bacterial DNA gyrase
  • Mycolic acid inhibitor, inhibits mycolic acid
  • Aminoglycoside, inhibits protein synthesis
  • Sulfonamide, inhibits bacteiran metabolism of folic acid

Question 61

Question
Which drug would be used as a treatment for urinary tract infections, nocardiosis infections, and toxoplasmosis?
Answer
  • Ciprofloxacin
  • Gentamicin
  • Penicillin
  • Trimethoprim-sulfamethoxazole

Question 62

Question
What is the mechanism of action and pharmacological class for trimethoprim-sulfamethoxazole?
Answer
  • fluroquinolone, inhibits bacterial DNA gyrase
  • sulfonamide, inhibits bacterial metabolism of folic acid
  • aminoglycoside, inhibits protein synthesis, disrupts membrane, kills bacteria

Question 63

Question
Which of the following drugs is a broad spectrum treatment of a wide range of helminth infections?
Answer
  • Mebendazole
  • Amphotericin B
  • Fluconazole
  • Cloroquine

Question 64

Question
What is the mechanism of action for Mebendazole?
Answer
  • Concentrates in food vacuoles of plasmodium residing in red blood cells
  • Inhibits microtubule formation and glucose uptake
  • Binds to ergosterol in fungal cell membranes and causes them to leak
  • Interferes with ergosterol synthesis

Question 65

Question
What is the therapeutic class for Amphotericin B?
Answer
  • Antihelminth
  • Antifungal
  • Antifungal (systemic)
  • Antimalarial

Question 66

Question
Which of the following drugs is the treatment of most fungi pathogenic to humans, the preferred drug for most systemic mycoses?
Answer
  • Fluconazole
  • Cloroquine
  • Mebendazole
  • Amphotericin B

Question 67

Question
Select all the following drugs that are polyenes.
Answer
  • Amphotericin B
  • Echinocandin
  • Griseofulvin
  • Nystatin

Question 68

Question
What is the therapeutic class for the drug Fluconazole?
Answer
  • Antihelminth
  • Antifungal
  • Antibacterial
  • Antiviral
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