450600
Description
Quiz by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
almost 11 years ago
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Question 1
Question
What is the main role of a molecular chaperone?
Answer
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Assist in the folding of other proteins
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Assist in the unfolding of other proteins
-
Assist in the assembly of other proteins
-
Assist in the disassembly of other proteins
Question 2
Question
Chaperone proteins are permanent parts of the proteins they fold
Answer
- True
- False
Question 3
Question
Why are chaperone proteins necessary?
Answer
-
Some proteins have complex folding pathways,
-
Some proteins are inherently soluble
-
Useful for multimeric assembly
-
So many proteins folding and interacting mean some need help
Question 4
Question
Name the role of the domain highlighted in bacterial trigger factor
Answer
-
PPIase domain
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Interacts with polypeptide as it comes off the ribosome
-
Binds to L23 of the ribosome
Question 5
Question
The highlighted domain of Bacterial trigger factor binds to L23 of the ribosome
Answer
- True
- False
Question 6
Question
The bacterial ribosome and bacterial trigger factor form a complex, so the protein is folded as it comes off the ribosome
Answer
- True
- False
Question 7
Question
The N-domain of the bacterial trigger factor bind to what subunit of what size ribosome?
Answer
-
L23
-
L24
-
L25
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50s
-
40s
-
30s
Question 8
Question
After the protein interacts with the T.F, it may interact with what proteins?
Answer
-
DNAK
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DNAJ
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DNAL
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Gro-EL
-
Gro-ER
Question 9
Question
What percent of proteins can fold unaided after interacting with DNAK/J?
Answer
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70%
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65%
-
75%
Question 10
Question
10-15% of proteins need to use the lidded protein chaperone syastem
Answer
- True
- False
Question 11
Question
15-18% of proteins need further _ interactions?
Answer
-
DNAK
-
DNAJ
-
Gro-El
Question 12
Question
Yeast has no trigger factor
Answer
- True
- False
Question 13
Question
In yeast, what protein folding complex interacts with the proteins first?
Answer
-
Nascent Polypeptide Associated Complex (NAC)
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The Ribosome Associated Complex (RAC)
-
CCT
Question 14
Question
The RAC complex is made of which proteins?
Answer
-
Zuptin
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Hsp40
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SSZ
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Hsp70
Question 15
Question
SSB is separated from the RAC but also chaperones protein folding
Answer
- True
- False
Question 16
Question
The NAC is made of A and B homologues
Answer
- True
- False
Question 17
Question
What is the role of the NAC?
Answer
-
Bind to nascent proteins and prevent aggregation
-
Binds to nascent proteins and degrades them based on protein concentrations in the cell
-
Binds to nascent proteins and folds them
Question 18
Question
Human cellss don't possess an NAC
Answer
- True
- False
Question 19
Question
Humans have an hRAC rather than an RAC
Answer
- True
- False
Question 20
Question
The human version of the RAC contains which two proteins?
Answer
-
MPP11
-
SSz
-
Hsp70L1
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SSb
Question 21
Question
Name the lidded protein chaperone found in yeast and humans
Answer
-
Gro-El
-
CCT
-
SSb
-
Hsp70L1
Question 22
Question
Name the circled sets of cytoplasmic folding proteins
Answer
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Hsp40/70- humans
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Hsp40/70- yeast
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SSa/YDJ1- yeast
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Ssa/Ydj1- humans
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Prefoldin
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