471718
Description
Quiz by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
almost 11 years ago
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Question 1
Question
Define leukamia
Answer
-
Neoplastic proliferation of haemopeoietic or lymphoid cells
-
Neoplastic proliferation of lymphoid cells
-
Neoplastic proliferation of bone marrow
Question 2
Question
In acute leukaemia, abnormality occurs in mature cells
Answer
- True
- False
Question 3
Question
Acute leukaemia is described as a block in differentiation
Answer
- True
- False
Question 4
Question
Acute leukaemia is caused by acute proliferation of...
Answer
-
Myeloblasts
-
Lymphoblasts
-
Both (rare)
-
Both (most common)
Question 5
Question
What are the symptoms of chronic leukaemia?
Answer
-
No block in differentiation
-
Block in differentiation
-
Low proliferation
-
High proliferation
Question 6
Question
Acute leukaemia is recognised by a certain type of cell being up to 50% of bone marrow cells?
Answer
-
Blasts
-
Reticulocytes
-
Lympocytes
Question 7
Question
In A.L, there are often reticulocytes in the peripheral blood
Answer
- True
- False
Question 8
Question
Leukaemia is caused by clonal proliferation from a single cell
Answer
- True
- False
Question 9
Question
How can you (sometimes) differentiate between a myeloblast and a lymphoblast?
Answer
-
Myeloblasts have auer rods
-
Lymphoblasts have auer rods
-
Myeloblasts have a large, pale nucleus
-
Lymphoblasts have a large, pale nucleus
Question 10
Question
MUD stands for
Answer
-
Matched Unrelated Donor
-
Myeloblast Unknown Death
-
Myeloblasts Under Duress
Question 11
Question
Remission - no disease in the blood
Answer
- True
- False
Question 12
Question
Why use the Minimal Residual Disease (MUD)?
Answer
-
Assess chances at relapse/need for further treatment
-
Assess effectiveness of drug
-
Prevent remission
Question 13
Question
BMT - Bone Marrow Transplant
Answer
- True
- False
Question 14
Question
B Cell Acute Lymphoblastic Leukaemia has a poor prognosis for children but a good one for adults
Answer
- True
- False
Question 15
Question
Which of the following is has the poorer prognosis
Answer
-
Acute T-Cell Precursor Lymphoblastic
-
Acute B-Cell Precursor Lymphoblastic
Question 16
Question
What is found in cytogenetic testing of ALL?
Answer
-
Hyperploidy
-
Aneuploidy
-
Nullosomy
Question 17
Question
Which of the following are found in ALL cytochemistry?
Answer
-
MPX/SB are neg
-
MPX/SB are pos
-
PAS block pos
-
PAS block neg
Question 18
Question
Which of the following are found in Immunophenotyping for ALL?
Answer
-
CD19
-
CD7
-
CD10
Question 19
Question
What is true of AML?
Answer
-
Inc WBC
-
Dec RBC
-
Dec Plateles
-
Inc RBC
-
Inc Platelets
Question 20
Question
AML means there is no normal cells
Answer
- True
- False
Question 21
Question
What markers are used in Flow Cytometry to identify AML?
Answer
-
CD13
-
CD33
-
CD12
-
CD4
Question 22
Question
AML is more common in adult women
Answer
- True
- False
Question 23
Question
When is AML called 'De Novo'
Answer
-
When it occurs for the first time
-
If it occurs secondary to other malignancies
-
If it never relapses
Question 24
Question
Which of the following is common in AML (as opposed to ALL)
Answer
-
CNS leukaemia
-
Lymph, spleen and gum problems
-
Lymphodenopathy
Question 25
Question
Match up the following- A = Fatigue, B= Fever/Infections, C= Spontaneous Bruising
1 = Low Platelets 2= Low Hb 3 = Low WBC
Answer
-
A2, B3, C1
-
A1, B2, C3
-
A3 B2 C1
Question 26
Question
CML- accumulation of mature myeloid cells
Answer
- True
- False
Question 27
Question
Genetic anomalies in CML occur low down where they effect cells
Answer
- True
- False
Question 28
Question
What happens in 95% of cases to cause AML?
Answer
-
Chromosome 22 shortens
-
Linking BCR & ABL genes together
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Chromosome 22 inverts
-
Chromosome 22 lengthens
Question 29
Question
In indentifying CML, immunophenotyping is useless
Answer
- True
- False
Question 30
Question
CML is more common in adult men
Answer
- True
- False
Question 31
Question
What is the WBC in CML?
Answer
-
>50 x 10^9/l
-
<30 x 10^9/l
-
>75 x 10^9/l
Question 32
Question
What will be found in a CML bone marrow sample?
Answer
-
Bone marrow is hypercellular
-
Bone marrow is hypocellular
-
Myeloid cells are present at all developmental stages
-
Inc Neutraphil Alkaline Phosphatase
-
Red Neutraphil Alkaline Phosphatase
Question 33
Question
Glivec stops CML cells dividing, but is expensive
Answer
- True
- False
Question 34
Question
CLL- Neoplastic proliferation of mature looking lymphocytes
Answer
- True
- False
Question 35
Question
What ususally happens in CML?
Answer
-
Lymphoids form masses in the bone marrow, spleen and lymph nodes
-
Lymphoids lyse and release contents as they are made poorly
-
Lymphs begin attacking body cells
Question 36
Question
In CLL, the lymph population can be over 300x the normal
Answer
- True
- False
Question 37
Question
What are smear cells?
Answer
-
Cells that rupture during a smear
-
Cells so malleable they look like smudges
-
Cells so deformed they form masses, which look like smears
Question 38
Question
In CLL, the bone marrow is <25% lymphocytes
Answer
- True
- False
Question 39
Question
What does immunophenotyping in CLL tell us?
Answer
-
Clonality
-
Which lymph cells they are
-
The markers
Question 40
Question
CLL is more common in old men
Answer
- True
- False
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