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Pharmaceutics I

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Quiz on Pharmaceutics I, created by Jon dL on 07/03/2017.
Jon dL
Quiz by Jon dL, updated more than 1 year ago
Jon dL
Created by Jon dL almost 8 years ago
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Resource summary

Question 1

Question
By the definitions from out notes for disperse systems, “Generally, a liquid preparation in which a finely divided, insoluble or immiscible material is distributed throughout a vehicle”, what is the minimum number of phases present in a dispersed system?
Answer
  • 1
  • 2
  • 3

Question 2

Question
The distinction between the terms coarse, fine, colloidal dispersion is based upon what property of the dispersed phase?
Answer
  • Solid state
  • Particle size
  • Molecular weight
  • Chemical structure

Question 3

Question
Why might a dispersed phase containing drug be formulated in a dispersion medium in which it was insoluble?
Answer
  • To increase the solubility
  • To mask bitter tastes
  • To increase the viscosity
  • To decrease the viscosity
  • None of the above

Question 4

Question
Given the equation for Stoke’s law of settling below, by how much you have to increase the viscosity to offset a particle size increase of a factor of two?
Image:
e91b8e10-5bf9-4714-9780-dcec03ac8112 (image/png)
Answer
  • Factor of 1/2
  • Factor of 2
  • Factor of 4

Question 5

Question
Given a suspension with a fixed particle size distribution, what would be true if each powder particle displaced its own weight of dispersing phase (i.e. density of dispersed phase = density of dispersion medium)?
Answer
  • The viscosity would be infinite
  • The settling rate will be very high
  • The settling rate would be zero
  • The particle size would approach colloidal dimensions

Question 6

Question
The primary mechanism of altering dispersion medium properties is modification of:
Answer
  • Density
  • Viscosity
  • Dielectric constant

Question 7

Question
Which of the following characteristics is NOT desirable in the case of suspension dosage forms?
Answer
  • Flocculation with formulation of loosely bound aggregates
  • Flocculation with formulation of strongly bound aggregates
  • Formation of loose sediment

Question 8

Question
An advantage of a shear thinning formulation includes:
Answer
  • Ease of mixing with relatively mild shaking of the container
  • Lower viscosity on standing to prevent settling
  • Caking of needle shaped particles

Question 9

Question
Under what conditions would you compound a suspension using benzyl alcohol or propylene glycol for preemies?
Answer
  • Only for acute usage
  • Only for antibiotics
  • Never

Question 10

Question
You are asked to compound a suspension of a drug normally dispensed as a solid dosage form. Why is it prudent to determine if a liquid dosage form is also commercially available?
Answer
  • You can save the effort and advise the patient they must wait until you can order the commercial dosage form
  • If a commercial liquid dosage form isn’t available, it may indicate a potential chemical stability problem
  • If a commercial liquid dosage form isn’t available, it may indicate a potential physical stability problem
  • Both B and C

Question 11

Question
Select the choices that correctly fill the blanks in the following statement: the three minimum requirements (i.e., 3 rules) needed for form a stabilized emulsion are 1) ____ 2)____ 3)____.
Answer
  • 1) Components forming at least 2 phases, 2) a component to stabilize the interface between the internal and external (continuous) phase, 3) sufficient energy input to break up each phase into droplets.
  • 1) At least one solid component 2) amphiphilic surfactant molecules, 3) adjustment to physiologic pH
  • 1) Component forming liquid crystalline phases, 2) a component to overcome the “double layer between the internal and external (continuous) phase, 3) sufficient energy input to break up each phase into droplets.
  • All of the above

Question 12

Question
Which of the following statements is NOT a valid criterion for suspecting an emulsion is physically unstable?
Answer
  • Dispersed phase tends to form aggregates of globules on standing
  • Aggregates of the dispersed phase may be re-dispersed by shaking
  • Large globules or aggregates of globules rise to the top or fall to the bottom of container forming a concentrated layer of dispersed phase
  • All or part of the liquid in the dispersed phase separates to form a distinct layer

Question 13

Question
Patients should virtually never be instructed to store an emulsion dosage form:
Answer
  • In the refrigerator
  • At room temperature
  • In the freezer

Question 14

Question
The HLB system is primarily useful for matching a non-ionic surfactant system with the oil phase in an emulsion. Given that: HLB Span 60 = 4.7, and HLB of Tween 60 = 14.9 estimated fraction of Span 60 and Tween 60 needed to achieve an HLB of 12 is approximately (to the nearest %):
Answer
  • 72 and 28% respectively
  • 28 and 72% respectively
  • None of the above

Question 15

Question
A magma is a:
Answer
  • Two phase gel in which the gel mass does not consists of floccules of small distinct particles
  • One phase gel in which the gel mass consists of floccules of small distinct particles
  • Two phase gel in which the gel mass consist of floccules of small distinct particles

Question 16

Question
In a colloidal dispersion the particle size is:
Answer
  • Much smaller than typical molecule dimensions
  • Much larger than typical molecule dimensions
  • The same or smaller than typical molecule dimensions

Question 17

Question
Which of following is FALSE in case of gel formulation exhibiting syneresis?
Answer
  • A measurable increase in volume of Gel
  • A non-measurable change in the volume of Gel
  • A measureable decrease in volume of Gel
  • A and B
  • B and C

Question 18

Question
What is a major function of glycerin in the carboxymethylcellulose based gel formulations?
Answer
  • To prevent drying of Gel
  • Sweetner
  • Antioxidant

Question 19

Question
Which of following if true of aerosol used to provide an airborne mist?
Answer
  • Particle size >50μm
  • Particle size <50 μm
  • Particle size <1μm
  • None of above

Question 20

Question
A properly prepared pharmaceutical suspension should settle slowly and should readily re dispersed upon gentle shaking on the container
Answer
  • True
  • False

Question 21

Question
Which of the following excipients should not be used in the formulation of a Carboxymethylcellulose-based gel?
Answer
  • Preservative
  • Glycerin
  • Alcohol
  • None of the above

Question 22

Question
Stability is an important consideration in the formulation of emulsions. Which of the following represents an irreversible phenomenon in terms of re-dispersion of emulsion?
Answer
  • Creaming
  • Coalescence of droplets
  • Flocculation
  • None of the above

Question 23

Question
Given that the API is soluble in water, which of the following type of emulsion is desirable to formulate?
Answer
  • O/W
  • W/O
  • None of the above

Question 24

Question
When you decrease the particle size of disperse phase by factor of 10, then the settling velocity will decrease by a factor of:
Answer
  • 10
  • 100
  • 1000

Question 25

Question
What is a primary reason to formulate the powders for suspension?
Answer
  • To facilitate transport and ease of administration
  • Maintain the stability of API
  • Improve patient compliance
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