Copy and Edit

Melanoma - NHS - Cell Biology & Cellular Pathology

Description

undergraduate second year Biomedical science 2nd year (Cell Biology & Cellular Pathology) Quiz on Melanoma - NHS - Cell Biology & Cellular Pathology, created by Idont Evencare on 20/03/2017.
Idont Evencare
Quiz by Idont Evencare, updated more than 1 year ago
Idont Evencare
Created by Idont Evencare over 7 years ago
5
0
0

Resource summary

Question 1

Question
Melanocytes are
Answer
  • located in epidermis
  • located in dermis
  • originated from the neural crest
  • originated from adipoblasts
  • dendritic cells
  • pseudo-unipolar cells
  • place of melanin anabolism
  • place of melanin catabolism

Question 2

Question
Which of the following is the correct pathway of melanin synthesis?
Answer
  • Tyrosine (oxidaton by tyrosinase) --> di-hydroxy phenylalanine (oxidation by tyrosinase) --> melanin
  • Tyrosine (oxidaton by tyrosinase) --> di-hydroxy methylmelanin (oxidation by tyrosinase) --> melanin
  • Tyrosinase (oxidaton by tyrosine) --> di-hydroxy methyllalanine (reduction by tyrosine) --> melanin
  • Di-hydroxy methylalanine (oxidaton by tyrosinase) --> tyrosine (reduction by tyrosinase) --> melanin
  • Di-hydroxy methylalanine (oxidaton by tyrosine) --> tyrosinase (reduction by tyrosine) --> melanin

Question 3

Question
What are the three most common types of skin cancer?
Answer
  • malignant melanoma
  • basal cell melanoma
  • malignant basal keratoses
  • basal cell carcinoma
  • squamous cell carcinoma
  • merkel cell carcinoma

Question 4

Question
Which of the following is the commonest skin cancer
Answer
  • basal cell carcinoma
  • squamous cell carcinoma
  • malignant melanoma

Question 5

Question
Which of the following is the easiest skin cancer to treat
Answer
  • squamous cell carcinoma
  • basal cell carcinoma
  • malignant melanoma

Question 6

Question
Squamous cell carcinoma rarely metastasises.
Answer
  • True
  • False

Question 7

Question
Melanoma is the most common cancer in elderly
Answer
  • True
  • False

Question 8

Question
Melanoma metastises
Answer
  • very early
  • only if untreated
  • to most body sites
  • almost exclusively to joints and liver and heart only
  • commonly to lymph nodes

Question 9

Question
Melannoma is the moset rapidly increasing common cancer type
Answer
  • True
  • False

Question 10

Question
What are the predisposing factors for melanoma?
Answer
  • exposure to sun
  • alcohol abuse
  • DNA repair mechanism mutations
  • P16 gene
  • CDKN2A
  • PK20 gene
  • CD150C
  • dysplastic naevi
  • skin colour
  • number of pre-existing moles

Question 11

Question
The types of melanoma are
Answer
  • Nodular Melanoma
  • Acral lentiginous melanoma
  • Lentigo maligna melanoma
  • Superficial spreading
  • Lego malaria melanoma
  • Occular mesenchymous melanoma
  • Cranial melanoma
  • Chronic hepatocyte melanoma

Question 12

Question
ABCD rule in melanoma diagnosis stands for
Answer
  • A – aplasticity B – Border irregularity C – colour D – distance
  • A – asymmetry B – Border irregularity C – colour D – diameter
  • A – asymmetry B – Border integrity C – change in size D – distance
  • A – aplasticity B – basal cell symetry C – colour D – diameter
  • A – aplasticity B – Border integrity C – change in size D – distance

Question 13

Question
Initial diagnosis of melanoma is performed by
Answer
  • examination using bright light and magnification
  • histology using ziehl-neelsen stain
  • biopsy followed by ELISA
  • ELISA
  • biopsy followed by PCR

Question 14

Question
Common antibodies used in diagnosis of melanoma by immunohistochemistry include
Answer
  • Melan M
  • Melan A
  • HMB 45
  • S 100
  • CDK 150
  • JK 480

Question 15

Question
Diagnosis of melanoma is performed by
Answer
  • +/- immmunohistochemistry
  • +/- immunocytochemistry
  • special stain histology
  • H/E stain histology
  • ELISA
  • laparoscopy

Question 16

Question
Melanin does not always have to be present in melanoma
Answer
  • True
  • False

Question 17

Question
In histological examination of melanoma, which if the following are typically observed?
Answer
  • Prominent nucleoli
  • Missing nucleoi
  • Irregular nucleoi
  • Popcorn cells
  • Reed-Strenberg cells
  • Large cells
  • Small cells

Question 18

Question
Special stains are the most common diagnostic tool in melanomas
Answer
  • True
  • False

Question 19

Question
Melanin is a
Answer
  • big strong cookie booboo
  • strong reducing agent
  • strong oxidising agent
  • reactively inert molecule

Question 20

Question
Special stains can be used for the diagnosis of amelanotic melanomas
Answer
  • True
  • False

Question 21

Question
Immunohistochemistry can be used for the diagnosis of amelanotic melanomas
Answer
  • True
  • False

Question 22

Question
Immunocytochemistry is used in diagnosis of melanoma in
Answer
  • Difficult cases
  • Metastasis
  • Micro invasion
  • None of the above
  • All of the above
  • Reed-Sternberg melanoma

Question 23

Question
The target protein for S100 is [blank_start]not specific for melanoma[blank_end], HMB45 is [blank_start]sometimes absent from melanomas[blank_end] and Melan A is sometimes found in [blank_start]non-melanoma tumours[blank_end].
Answer
  • not specific for melanoma
  • sometimes absent from melanomas
  • non-melanoma tumours

Question 24

Question
Clinical staging is based on
Answer
  • histological staging of primary tumour
  • histological staining of metastasis
  • lymph node involvement
  • basal cell involvement
  • metastases
  • age of the patient

Question 25

Question
Breslow [blank_start]depth[blank_end] measures the [blank_start]thickness of tumour[blank_end] whereas Clark [blank_start]levels[blank_end] measure the [blank_start]depth of invasion[blank_end]. Breslow method is [blank_start]more accurate[blank_end] than Clark method.
Answer
  • depth
  • thickness of tumour
  • levels
  • depth of invasion
  • more accurate
  • less accurate

Question 26

Question
Clinical staging does NOT rely on the histological measurement of
Answer
  • Ulceration
  • Lymphoid infiltration
  • Mitotic activity
  • Vascular ivasion
  • Dendritic necrosis
  • Microscopic satellites

Question 27

Question
Treatment of melanoma is the same regardless of the stage
Answer
  • True
  • False

Question 28

Question
Treatment of melanoma can include the removal of
Answer
  • all metastases
  • sentinel lymph node/s
  • primary tumour, minimum 5mm
  • primary tumour, minimum 2mm
  • all moles

Question 29

Question
Biological therapy of melanoma often consists of
Answer
  • BRAF inhibitor drug regimes
  • Interleukin alpha inhibitor drug regime
  • Low salt and fat intake diet
  • Broad spectrum drugs
  • Localised irradiation

Question 30

Question
BRAF 600 gene is found in about half the melanoma patients
Answer
  • True
  • False

Question 31

Question
Punch skin biopsy is the only method of obtaining histological tissue for diagnosis of melanoma.
Answer
  • True
  • False
Show full summary Hide full summary

Want to create your own Quizzes for free with GoConqr? Learn more.

Similar

Cell Transport
Elena Cade
Function and Structure of DNA
Elena Cade
Cells And Cell Techniques - Flashcards (AQA AS-Level Biology)
Henry Kitchen
Cell Structure
megan.radcliffe16
AQA Biology 12.1 cellular organisation
Charlotte Hewson
Biology AQA 3.1.3 Cells
evie.daines
GCSE AQA Biology - Unit 2
James Jolliffe
Cells and the Immune System
Eleanor H
Biology Unit 2 - DNA, meiosis, mitosis, cell cycle
DauntlessAlpha
Mitosis
Selam H
Unit 1 flashcards
C R
Browse Library