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Bio 211 Final Exam

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Spring 2017 - Final Exam - Dr. Jones
Toni Demoff
Quiz by Toni Demoff, updated more than 1 year ago
Toni Demoff
Created by Toni Demoff over 7 years ago
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Resource summary

Question 1

Question
Fill in the blank for each function with its corresponding match. - [blank_start]Schwann Cell[blank_end]: myelin-producing neuroglia of the peripheral nervous system - [blank_start]Neuroglia[blank_end]: fill spaces, provide structure, produce myelin - [blank_start]Oligodendrocytes[blank_end]: form the myelin sheath in the brain and spinal cord - [blank_start]Astrocytes[blank_end]: found between blood vessels and neurons. Fills scar tissue in brain, form BBB (blood brain barrier)
Answer
  • Schwann Cell
  • Neuroglia
  • Oligodendrocytes
  • Astrocytes

Question 2

Question
How is the RMP established and maintained?
Answer
  • Na+ moves out and K+ moves in, ATPase maintains RMP
  • The ATPase releases MG2+ which allows for Ca+ to flow through the NMDA
  • More AMPA channels bind to the cell membrane
  • K+ moves out, Na+ moves in, ATPase maintains RMP

Question 3

Question
Which of the following is true of the Goldman equation?
Answer
  • Needed when a single ion is crossing over the membrane
  • Needed when more than one ion is crossing over the membrane

Question 4

Question
Which of the following is true of the Nernst equation?
Answer
  • Needed when more than one ion is crossing over the membrane
  • Needed when one ion is crossing over the membrane

Question 5

Question
Which of the following variable's change when new conditions are presented?
Answer
  • Graded potential
  • RMP potential
  • Iontropic potential
  • mM values
  • Action potential
  • EPSP
  • IPSP

Question 6

Question
The process of starting/stopping an AP: [blank_start]Gated[blank_end] Na+ and K+ channels are closed, only [blank_start]leak[blank_end] channels are open. [blank_start]RMP[blank_end] is maintained and you need threshold before [blank_start]depolarization[blank_end] occurs in order for an [blank_start]AP[blank_end] to occur.
Answer
  • Gated
  • leak
  • RMP
  • depolarization
  • AP

Question 7

Question
Match the term with its definition in respect to action potentials. - [blank_start]Depolarization[blank_end]: membrane becomes more positive away from the RMP - [blank_start]Re-polarization[blank_end]: membrane becomes more negative away from the RMP - [blank_start]Hyper-polarization[blank_end]: membrane becomes even more negative than the RMP
Answer
  • Depolarization
  • Re-polarization
  • Hyper-polarization

Question 8

Question
The role of the Na/K ATPase is to reset the chemical conditions in the RMP. After repolarization occurs the pump restores electrical conditions.
Answer
  • True
  • False

Question 9

Question
Label the diagram with is respective phases.
Image:
1221 Action Potential (image/jpeg)
Answer
  • depolarization
  • resting state
  • hyperpolarization
  • repolarization

Question 10

Question
Fill in the blank to explain how one neuron signals to another once an AP reaches the axon terminal in the pre-synaptic neuron. An AP in the axon terminal causes [blank_start]voltage gated[blank_end] Ca+ channels to [blank_start]open[blank_end] and enter the cell. Ca+ inside the cell causes the [blank_start]synaptic vesicle[blank_end] to [blank_start]fuse[blank_end] with the membrane. Each has a certain amount of neurotransmitter released into the cleft. Neurotransmitter [blank_start]diffuses[blank_end] across the cleft. Neurotransmitter [blank_start]binds[blank_end] to receptors on the post synaptic neuron where it can act.
Answer
  • voltage gated
  • open
  • synaptic vesicle
  • fuse
  • diffuses
  • binds

Question 11

Question
Which of the following is true of Iontropic NT receptors?
Answer
  • Monamines
  • AA
  • Neuropeptides
  • ACh
  • allows ions to flow through central pores
  • changes inside the cell
  • EPSP/IPSP
  • usually involves G protein
  • fast/brief period
  • slow/long period

Question 12

Question
EPSP: leads to [blank_start]depolarization[blank_end] of the neuron. [blank_start]Excited[blank_end] the post synaptic neuron IPSP: leads to [blank_start]hyper-polarization[blank_end] of the neuron. [blank_start]Inhibits[blank_end] the post synaptic neuron
Answer
  • depolarization
  • hyper-polarization
  • Excited
  • Inhibits

Question 13

Question
[blank_start]Spatial summation[blank_end]: simultaneous EPSP in different location - produces AP, EPSP & IPSP in different location - reduces chance of AP [blank_start]Temporal summation[blank_end]: rapid repeat of EPSP in same location - produces AP
Answer
  • Spatial summation
  • Temporal summation

Question 14

Question
[blank_start]Myelinated[blank_end]: AP is faster, contains [blank_start]nodes of ranvier[blank_end]: voltage gated Na+ channels where AP is generated. [blank_start]Un-myelinated[blank_end]: AP is slower, contains [blank_start]leak channels[blank_end]: less flow of ions, difficult to get incoming Na+ charges to move.
Answer
  • Myelinated
  • Un-myelinated
  • nodes of ranvier
  • leak channels

Question 15

Question
If the Na/K ATPase stopped working the membrane would be more negative which would be harder to start an AP.
Answer
  • True
  • False

Question 16

Question
The brains ability to form or change synaptic connections is known as _____________.
Answer
  • Long term potentiation
  • Synaptic Pruning
  • Neuroplasticity
  • Myelination

Question 17

Question
Early LTP: [blank_start]AMPA[blank_end] receptor becomes [blank_start]excitatory[blank_end] which leads to an increase of [blank_start]Na+[blank_end] which then depolarizes the post synaptic cell. The EPSP that has been started releases the [blank_start]Mg+[blank_end] from the [blank_start]NMDA[blank_end] receptor and allows [blank_start]Ca+[blank_end] to enter. Late LTP: Begins when [blank_start]sustained[blank_end] activation from early LTP leads to protein synthesis. The post synaptic changes increase dendritic spines and increase AMPA receptors.
Answer
  • AMPA
  • excitatory
  • Na+
  • Mg+
  • NMDA
  • Ca+
  • sustained

Question 18

Question
Match the term with its corresponding scenario: [blank_start]Ca2+ levels[blank_end]: a decrease in this could cause a neuron to not pass through the NMDA receptors resulting in no LTP. [blank_start]AMPA receptors[blank_end]: if there are none of these in early LTP then there will not be any LTP at all but if the release of NMDA occurs there none to make the membrane more permeable; causing late LTP to occur slower or not at all. [blank_start]Lack of threshold[blank_end]: this would result in Na+ not flowing through the cell therefore no LTP would be initiated. Mg2+ would possibly block the NMDA receptor and no late LTP would occur. [blank_start]Excess Mg2+[blank_end]: this would cause for more Na+ to flow in causing depolarization of the cell faster [blank_start]Lack of Na+[blank_end]: there would be no EPSP, no Mg2+ release, no LTP
Answer
  • Ca2+ levels
  • AMPA receptors
  • Lack of threshold
  • Excess Mg2+
  • Lack of Na+

Question 19

Question
The [blank_start]photo-receptor[blank_end] cell receives light signals and is located in the [blank_start]retina[blank_end].
Answer
  • photo-receptor
  • bi polar
  • ganglionic
  • retinal
  • retina
  • fovea
  • macula
  • primary visual cortex

Question 20

Question
The rods are used for [blank_start]dim[blank_end] light and [blank_start]high[blank_end] sensitivity. The cones are used for [blank_start]bright[blank_end] light and [blank_start]low[blank_end] sensitivity.
Answer
  • dim
  • high
  • bright
  • low

Question 21

Question
The macula contains the fovea.
Answer
  • True
  • False

Question 22

Question
The fovea has a low density of photoreceptors.
Answer
  • True
  • False

Question 23

Question
What photo-receptors are found in the periphery?
Answer
  • Cones
  • Rods

Question 24

Question
Which ion is released when signaling photo-receptors?
Answer
  • Na+
  • K+
  • Ca+
  • Cl-

Question 25

Question
Pathway of light from eye to brain. [blank_start]Light[blank_end] -> [blank_start]Retina[blank_end] -> [blank_start]Photoreceptor[blank_end] -> [blank_start]Bi Polar Cell[blank_end] -> [blank_start]Ganglionic Cell[blank_end] -> [blank_start]Optic Nerve[blank_end] -> [blank_start]Optic Chiasm[blank_end] -> [blank_start]LGN[blank_end] -> [blank_start]V1[blank_end]
Answer
  • Light
  • Retina
  • Photoreceptor
  • Bi Polar Cell
  • Ganglionic Cell
  • Optic Nerve
  • Optic Chiasm
  • LGN
  • V1

Question 26

Question
What axons make up the optic nerve?
Answer
  • Bi polar cell
  • Photoreceptor
  • Ganglionic Cell
  • Nerve endings

Question 27

Question
The optic chiasm is the crossing over point for vision.
Answer
  • True
  • False

Question 28

Question
Label the pathway from the outer to inner ear. [blank_start]External meatus[blank_end] -> [blank_start]Tympanic Membrane[blank_end] -> [blank_start]Malleus[blank_end] -> [blank_start]Incus[blank_end] -> [blank_start]Stapes[blank_end] -> [blank_start]Oval Window[blank_end] -> [blank_start]Inner Ear[blank_end]
Answer
  • External meatus
  • Tympanic Membrane
  • Malleus
  • Incus
  • Stapes
  • Oval Window
  • Inner Ear

Question 29

Question
Top tube: [blank_start]scala vestibule[blank_end]: connects to the oval window Middle tube: [blank_start]scala media[blank_end]: holds organ of corti - hair cells that change waves to electric signals - sits on basilar membrane and covered by tectorial membrane Bottom tube: [blank_start]scala tympani[blank_end]: connects to round window
Answer
  • scala vestibule
  • scala media
  • scala tympani

Question 30

Question
The stereocilia depolarizes in response to sound waves.
Answer
  • True
  • False

Question 31

Question
Sound waves come in and bend the stereocilia which allow for Na+ to flow in.
Answer
  • True
  • False

Question 32

Question
The [blank_start]endolymph[blank_end] is high in potassium.
Answer
  • endolymph
  • perilymph

Question 33

Question
Stereocilia is stuck in the [blank_start]tectorial membrane[blank_end] and allows for tugging when sound waves pass through. The organ of corti sits on the [blank_start]basilar membrane[blank_end].
Answer
  • tectorial membrane
  • basilar membrane

Question 34

Question
The [blank_start]depolarization[blank_end] of stereocilia causes them to release [blank_start]glutamate[blank_end] onto the [blank_start]spiral ganglion[blank_end] cells of the cochlear nerve.
Answer
  • depolarization
  • hyperpolarization
  • repolarization
  • crossing over
  • glutamate
  • potassium
  • sodium
  • calcium
  • spiral ganglion
  • hair
  • odorant
  • receptor

Question 35

Question
Cilia repolarize as K+ leaves the endolymph.
Answer
  • True
  • False

Question 36

Question
Fill in the blanks for the pathway of sound from the cochlea to the brain. [blank_start]Hair Cell[blank_end] -> [blank_start]Spiral Ganglion Axon[blank_end] -> [blank_start]Cochlear Nerve[blank_end] -> [blank_start]Cochlear Nuclei in the medulla[blank_end] -> [blank_start]Superior Olive in the pons[blank_end] -> [blank_start]Inferior Colliculus in the midbrain[blank_end] -> [blank_start]Medial Geniculate Nucleus in the thalamu[blank_end]s -> [blank_start]A1 in the superior temporal lobe[blank_end].
Answer
  • Hair Cell
  • Spiral Ganglion Axon
  • Cochlear Nerve
  • Cochlear Nuclei in the medulla
  • Superior Olive in the pons
  • Inferior Colliculus in the midbrain
  • Medial Geniculate Nucleus in the thalamu
  • A1 in the superior temporal lobe

Question 37

Question
Where is the crossing over point for the auditory system?
Answer
  • medulla
  • midbrain
  • pons
  • thalamus

Question 38

Question
The primary auditory cortex is located in the Superior temporal lobe.
Answer
  • True
  • False

Question 39

Question
[blank_start]Pitch[blank_end] is based on frequency. High pitch: [blank_start]base of cochlea[blank_end] Low pitch: [blank_start]apex of cochlea[blank_end] [blank_start]Loudness[blank_end] is based on intensity Increased [blank_start]amplitude[blank_end] of waves: louder sounds
Answer
  • Pitch
  • base of cochlea
  • apex of cochlea
  • Loudness
  • amplitude

Question 40

Question
Explain the way in which odor molecules start an AP in sensory neurons. [blank_start]Odorant particles bind to receptors[blank_end] on the cilia -> [blank_start]transduction begins[blank_end] -> [blank_start]signals the G Protein[blank_end] -> [blank_start]cAMP production[blank_end] -> [blank_start]cAMP binds to open ion channels[blank_end] -> [blank_start]allow Na+ and Ca2+ to enter[blank_end] -> [blank_start]depolarization[blank_end]
Answer
  • Odorant particles bind to receptors
  • transduction begins
  • signals the G Protein
  • cAMP production
  • cAMP binds to open ion channels
  • allow Na+ and Ca2+ to enter
  • depolarization

Question 41

Question
Trace the path of olfaction signals from the nose to brain [blank_start]Mucus[blank_end] -> [blank_start]olfactory cells[blank_end] -> [blank_start]dendrite[blank_end] -> [blank_start]olfactory receptor[blank_end] -> [blank_start]basal cell[blank_end] -> [blank_start]axon[blank_end] -> [blank_start]olfactory gland[blank_end] -> [blank_start]olfactory nerve[blank_end] -> [blank_start]cribiform plate[blank_end] -> [blank_start]glomeruli[blank_end] -> [blank_start]mitral cell[blank_end] -> [blank_start]olfactory tract[blank_end]
Answer
  • Mucus
  • olfactory cells
  • dendrite
  • olfactory receptor
  • basal cell
  • axon
  • olfactory gland
  • olfactory nerve
  • cribiform plate
  • glomeruli
  • mitral cell
  • olfactory tract

Question 42

Question
How are different odors interpreted?
Answer
  • 100 different receptor types
  • 500 different receptor types
  • 350 different receptor types
  • unknown amount of receptor types

Question 43

Question
Which cells make up the olfactory nerve?
Answer
  • mitral cell
  • basal cell
  • epithelial cell
  • gustatory cell

Question 44

Question
Which of the following have pertain to taste buds?
Answer
  • Gustatory cells
  • Epithelial cells
  • Basal cells
  • Ganglionic cells
  • Olfactory cells

Question 45

Question
Gustatory cells are ciliated and bind to dissolved chemicals.
Answer
  • True
  • False

Question 46

Question
Match the NT to its tastant: T1R1: [blank_start]umami/MSG[blank_end] T1R2: [blank_start]sweet[blank_end] T1R3: [blank_start]sweet/umami[blank_end] T2: [blank_start]bitter[blank_end] ENaC: [blank_start]salty[blank_end] PKD2L: [blank_start]sour[blank_end]
Answer
  • umami/MSG
  • sweet
  • sweet/umami
  • bitter
  • salty
  • sour

Question 47

Question
[blank_start]T1R1 & T2[blank_end]: binds G protein -> increase IP3 Ca2+ -> open TRP channels -> depol. [blank_start]ENaC & PKD2L[blank_end]: enters through membrane Na+ channels -> depol.
Answer
  • T1R1 & T2
  • ENaC & PKD2L

Question 48

Question
Fill in the blanks for the path of taste bud to brain: [blank_start]Cranial nerves[blank_end] -> [blank_start]medulla oblongata[blank_end] -> [blank_start]Pons (medulla)[blank_end] -> [blank_start]VPN thalamus[blank_end] -> [blank_start]Primary Gustatory Cortex (insula)[blank_end] -> [blank_start]Hypothalamus (limbic system)[blank_end]
Answer
  • Cranial nerves
  • medulla oblongata
  • Pons (medulla)
  • VPN thalamus
  • Primary Gustatory Cortex (insula)
  • Hypothalamus (limbic system)

Question 49

Question
The direction in which sensory information travels is from spinal cord to periphery
Answer
  • True
  • False

Question 50

Question
Fill in the blanks to show the path of sensory information from mechanoreceptors to S1 using the MLP: [blank_start]Primary afferent[blank_end] -> [blank_start]medulla[blank_end] -> [blank_start]secondary afferent[blank_end] -> [blank_start]thalamus[blank_end] (where it crosses over) -> [blank_start]VPN[blank_end] -> [blank_start]tertiary afferent[blank_end] -> [blank_start]S1[blank_end] (parietal lobe)
Answer
  • Primary afferent
  • medulla
  • secondary afferent
  • thalamus
  • VPN
  • tertiary afferent
  • S1

Question 51

Question
Fill in the blank for the sensory information for nociceptors to S1 using the spinothalamic tract. -[blank_start]Spinal cord[blank_end] -> [blank_start]cross at ventral route[blank_end] -> [blank_start]medulla[blank_end]
Answer
  • Spinal cord
  • cross at ventral route
  • medulla

Question 52

Question
In the medial lemniscal pathway crossing over occurs in the [blank_start]thalamus[blank_end] and in the spinothalamic pathway crossing over occurs in the [blank_start]spinal cord[blank_end].
Answer
  • thalamus
  • medulla
  • spinal cord
  • pons
  • spinal cord
  • thalamus
  • medulla
  • pons

Question 53

Question
[blank_start]A delta[blank_end]: myelinated, fast conduction, skin pressure/touch vibration [blank_start]A beta[blank_end]: myelinated, sharp pain, cool/cold info [blank_start]C fibers[blank_end]: unmyelinated, slow conduction, pain, warm/hot information
Answer
  • C fibers
  • A delta
  • A beta

Question 54

Question
Match each mechano-receptor with the sensory information they detect: [blank_start]Merkel Cell[blank_end]: mostly in fingertips, feel touch [blank_start]Meisnner Corpuscle[blank_end]: respond to low freq. vibrations, brushing across skin, slippage of objects in hands [blank_start]Paccinian Corpuscle[blank_end]: poor spatial resolution, respond to high freq. vibration, use of tools
Answer
  • Merkel Cell
  • Meisnner Corpuscle
  • Paccinian Corpuscle

Question 55

Question
S1 is in the parietal lobe and is somatotopically organized
Answer
  • True
  • False

Question 56

Question
2 point discrimination is the regions far apart in the body synapse in the cortex close together.
Answer
  • True
  • False

Question 57

Question
Both Substance P and Glutamate ________ interneurons. - Secondary afferents in the spinal cord.
Answer
  • inhibit
  • excite
  • hyperpolarize
  • eliminate

Question 58

Question
How do endogeous opiods block incoming nociceptor signals in order to reduce the perception of pain? They all bind to opiod ligand -> release inhibitory [blank_start]NT[blank_end] on nociceptor neuron terminals in spinal cord and either block [blank_start]Ca2+[blank_end] channels or open [blank_start]K+[blank_end] channels.
Answer
  • NT
  • Ca2+
  • K+

Question 59

Question
Match each NT to its interneuron. Mu: [blank_start]endorphin[blank_end] Delta: [blank_start]enkephalin[blank_end] Kappa: [blank_start]dynorphin[blank_end]
Answer
  • endorphin
  • enkephalin
  • dynorphin

Question 60

Question
What structures below are a part of the NMJ? (CATA)
Answer
  • axon terminal of a neuron
  • ACh
  • Sarcolemma
  • synaptic cleft

Question 61

Question
During muscle contraction:
Answer
  • thin filaments allow thick filaments to slide on top
  • thin and thick filaments slide past each other
  • thin and thick filaments begin to convulse

Question 62

Question
Myosin heads bind to actin during muscle contraction
Answer
  • True
  • False

Question 63

Question
Match each term with their definition: - [blank_start]Sarcolemma[blank_end]: plasma membrane - [blank_start]Sarcoplasmic Reticulum[blank_end]: smooth ER; stores Ca2+ has voltage gated channels - [blank_start]Muscle Fiber[blank_end]: thing filaments, myosin attaches, think filaments binding site for actin and ATP.
Answer
  • Sarcolemma
  • Sarcoplasmic Reticulum
  • Muscle Fiber

Question 64

Question
The [blank_start]direct[blank_end] pathway signals inhibit some basal ganglia structures which lead to movement. The [blank_start]indirect[blank_end] pathway signals excite some basal ganglia structures which inhibit movement.
Answer
  • direct
  • indirect
  • indirect
  • direct

Question 65

Question
M1 is not organized somatotopically.
Answer
  • True
  • False

Question 66

Question
The size of the area determines the movement in M1.
Answer
  • True
  • False

Question 67

Question
Fill in the blanks with the pathway for motor movement from the brain to the muscle: [blank_start]M1[blank_end] -> [blank_start]pons[blank_end] -> [blank_start]medulla[blank_end] -> [blank_start]spinal cord[blank_end] -> [blank_start]muscle[blank_end]
Answer
  • M1
  • pons
  • medulla
  • spinal cord
  • muscle

Question 68

Question
Where do the motor neurons decussate?
Answer
  • thalamus
  • ventral horn
  • dorsal horn
  • medulla
  • pons

Question 69

Question
The UMN synapses on the LMN at the __________________
Answer
  • dorsal horn
  • ventral horn

Question 70

Question
Dorsal Horn: [blank_start]sensory neuron[blank_end] Ventral Horn: [blank_start]upper motor neuron[blank_end] Dorsal Route: [blank_start]sensory pathway[blank_end] Ventral Route: [blank_start]motor pathway[blank_end] [blank_start]Spinal Nerve[blank_end]: mixed between sensory & motor neurons [blank_start]Left[blank_end] side of spinal cord: motor/descending ([blank_start]efferent[blank_end]) pathway [blank_start]Right[blank_end] side of spinal cord: sensory/ascending ([blank_start]afferent[blank_end]) pathway
Answer
  • sensory neuron
  • upper motor neuron
  • upper motor neuron
  • sensory neuron
  • sensory pathway
  • motor pathway
  • motor pathway
  • sensory pathway
  • Spinal Nerve
  • Dorsal Nerve
  • Autonomic Nerve
  • Spinothalamic Nerve
  • Left
  • Right
  • efferent
  • afferent
  • Right
  • Left
  • afferent
  • efferent

Question 71

Question
Sensory neuron connect motor neurons through interneurons.
Answer
  • True
  • False

Question 72

Question
[blank_start]Flexor[blank_end] reflex causes automatic withdrawal of threatened body parts and uses simple reflex arc. [blank_start]Stretch[blank_end] reflex maintains posture and adjusts.
Answer
  • Flexor
  • Stretch
  • Stretch
  • Flexor

Question 73

Question
Proprioceptors _________________.
Answer
  • detect stretch and fire AP - causes muscle contraction
  • detect stretch and contains AP - constricting muscle contraction
  • maintain homeostasis
  • carry signals from outer motor neurons to inner

Question 74

Question
Proprioception is ...
Answer
  • the constriction of limbs
  • The reflex of limbs
  • The sensation of limbs
  • The involuntary movement of limbs

Question 75

Question
[blank_start]Autonomic[blank_end] NS: involuntary, impulses go to [blank_start]cardiac[blank_end] muscles [blank_start]Somatic[blank_end] NS: voluntary, impulses go to [blank_start]skeletal[blank_end] muscles
Answer
  • Autonomic
  • Somatic
  • Somatic
  • Autonomic
  • cardiac
  • skeletal
  • skeletal
  • cardiac

Question 76

Question
Check all that apply to the Parasympathetic Nervous System.
Answer
  • Constricts airways
  • Decrease heart rate
  • Increase digestion
  • Increase Urine Output
  • Decrease Blood Pressure
  • Increase heart rate
  • Decrease digestion
  • Decrease Urine Output
  • Dialtate Airways
  • Increase Blood Pressure

Question 77

Question
Receptor Types: - [blank_start]Nicotinic[blank_end]: stimulatory, found on skeletal muscles at the neuromuscular juntion, all postganglionic neurons. - [blank_start]Muscarinic[blank_end]: inhibitory/excitatory, found on all effector cells.
Answer
  • Nicotinic
  • Muscarinic
  • Muscarinic
  • Nicotinic

Question 78

Question
What Neurotransmitter is used for signaling? - Sympathetic: [blank_start]NE[blank_end] - Parasympathetic: [blank_start]ACh[blank_end]
Answer
  • NE
  • ACh

Question 79

Question
What type of fibers are used for in the SNS?
Answer
  • cholinergic
  • muscarinic
  • adrenergic
  • nicotinic

Question 80

Question
What type of fiber is used in the PNS?
Answer
  • adrenergic
  • cholinergic
  • muscarinic
  • nicotinic

Question 81

Question
The Central Nervous System is controlled by the Autonomic Nervous System.
Answer
  • True
  • False

Question 82

Question
Is the ANS controlled unconsciously by the CNS?
Answer
  • Yes
  • No
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