Created by die zwei ??
almost 7 years ago
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Pyknosis: nuclear shrinkage DNA condenses into shrunken basophilic mass |
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Karyiorrhexis: nuclear fragmentation |
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Karyolysis: nuclear fading |
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Coagulative necrosis recent MI |
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Coagulative necrosis of the heart |
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Coagulative necrosis of the kidney |
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Liquefactive necrosis in brain |
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Fat necrosis (in pancreas) |
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Caseous necrosis (due to TB) |
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Fibrinoid necrosis |
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Fibrinoid necrosis |
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loss of nuclei coagulative necrosis as a consequence of tissue hypoxia (due to atherosclerosis and thrombosis) and cell death MI |
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loss of nuclei coagulative necrosis as a consequence of tissue hypoxia (due to atherosclerosis and thrombosis) and cell death MI |
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loss of nuclei coagulative necrosis as a consequence of tissue hypoxia (due to atherosclerosis and thrombosis) and cell death MI |
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loss of nuclei coagulative necrosis as a consequence of tissue hypoxia (due to atherosclerosis and thrombosis) and cell death MI |
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loss of nuclei coagulative necrosis as a consequence of tissue hypoxia (due to atherosclerosis and thrombosis) and cell death MI |
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loss of nuclei coagulative necrosis as a consequence of tissue hypoxia (due to atherosclerosis and thrombosis) and cell death MI |
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loss of brain parenchyma and macrophages which have phagocytosed the dead brain tissue brain infarct |
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loss of brain parenchyma and macrophages which have phagocytosed the dead brain tissue brain infarct |
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loss of brain parenchyma and macrophages which have phagocytosed the dead brain tissue brain infarct |
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Granulomas with a necrotic center and a rim of epithelioid hystiocytes, and occasional multinucleated Langhans giant cells at the periphery Tuberculosis |
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Granulomas with a necrotic center and a rim of epithelioid hystiocytes, and occasional multinucleated Langhans giant cells at the periphery Tuberculosis |
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Granulomas with a necrotic center and a rim of epithelioid hystiocytes, and occasional multinucleated Langhans giant cells at the periphery Tuberculosis |
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Granulomas with a necrotic center and a rim of epithelioid hystiocytes, and occasional multinucleated Langhans giant cells at the periphery Tuberculosis |
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Granulomas with a necrotic center and a rim of epithelioid hystiocytes, and occasional multinucleated Langhans giant cells at the periphery Tuberculosis |
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Fat necrosis (Steatonecrosis) |
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Fat necrosis (Steatonecrosis) |
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Fat necrosis (Steatonecrosis) |
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Fat necrosis (Steatonecrosis) |
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Fibrinoid necrosis is surrounded by rim of epithelioid histiocytes, lymphocytes, and plasma cells |
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Fibrinoid necrosis is surrounded by rim of epithelioid histiocytes, lymphocytes, and plasma cells |
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Synovia Rheumatoid arthritis (RA) – is a chronic inflammatory disorder of autoimmune origin |
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Synovia Rheumatoid arthritis (RA) – is a chronic inflammatory disorder of autoimmune origin |
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Synovia Rheumatoid arthritis (RA) – is a chronic inflammatory disorder of autoimmune origin |
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H&E: Hematoxylin-eosin stain: |
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Histochemistry |
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Immunohistochemistry |
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Immunofluorescence: IgG (antibodies) in green Shows human glomerulus in nephritis |
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In situ hybridization: Her2 gene copy number in breast cancer tissue |
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Digital image analysis |
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Electron microscopy: kidney glomerulus: |
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H&E stain of kidney: In glomerulus is an acellular part (pathologic accumulation) |
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Congo Red staining: specific to amyloid process; brick red staining result |
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Congo Red staining: specific to amyloid process; brick red staining result |
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Congo Red – polarized light: |
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Amyloid, Congo Red, UV light |
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Amyloid under podocytes |
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F component of AA amyloid |
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Amyloid AL Immunotactoid glomerulopathy --> Light chain nephropathy Myeloma (cast) nephropathy |
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Amyloid AL Immunotactoid glomerulopathy Light chain nephropathy --> Myeloma (cast) nephropathy |
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Hyalinosis |
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Hyalinosis |
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Hyalinosis |
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Hyalinosis: Kimmelstiehl-Wilson nodules in diabetes |
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alcoholic hyalin |
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alcoholic hyalin |
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Steatosis: Lipocytes Normal hepatocytes |
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Atherosclerotic plaque |
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cholesterol crystals (due to atherosclerosis) |
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cholesterol crystals |
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Carbon (anthrax), anthracosis Black dots = pigments |
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Carbon (anthrax), anthracosis Black dots = pigments |
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Pigment accumulations |
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Pigment accumulations |
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Pigment accumulations |
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Pigment accumulations |
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Calcium on H&E basophilic amorphous deposit |
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Calcium on H&E basophilic amorphous deposit |
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Van Kossu stain for calcium |
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? |
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? |
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? |
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Hyalinosis, PAS stain |
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Immunofluoroscence Ig lambda in AL amyloid |
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Pigments (H&E) Perl stain for iron |
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Steatosis, H&E |
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Edema (white spots) |
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Edema Inflammatory |
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Edema Inflammatory |
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Edema Inflammatory |
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Edema Non-inflammatory lungs (alveoli) |
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Pulmonary edema in CHF transudate accumulation in alveoli |
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Acute congestion: (can have) engorged capillaries edema focal hemorrhage |
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Chronic passive congestion: can show fibrosis & hemosiderin-laden macrophages |
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Chronic passive congestion: can show fibrosis & hemosiderin-laden macrophages |
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Petechia (hemorrhage) |
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Venous thrombosis: composed of fibrin, platelets and blood cells |
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Venous thrombosis: composed of fibrin, platelets and blood cells |
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Venous thrombosis: composed of fibrin, platelets and blood cells |
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Venous thrombosis: composed of fibrin, platelets and blood cells |
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Acute congestion with edema |
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Venous thrombi |
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Venous thrombi (recanalized?!) |
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Venous thrombosis |
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Pulmonary "saddle" embolism |
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Arterial & venous thrombi Infective endocarditis |
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Fat embolism |
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Fat embolism? |
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Multiple Splenic... |
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Hemorrhagic infarct of adrenal glands in septic shock |
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Atheroembolic renal disease |
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Atheroembolic renal disease |
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Atheroembolic renal disease |
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Atheroembolic renal disease |
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Atheroembolic renal disease |
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Rheumatic mitral valve disease |
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Rheumatic mitral valve disease |
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Rheumatic mitral valve disease |
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Rheumatic mitral valve disease |
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Rheumatic mitral valve disease |
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Rheumatic mitral valve disease |
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Rheumatic mitral valve disease |
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Venous thrombosis of the leg and pulmonary thromboembolism |
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Venous thrombosis of the leg and pulmonary thromboembolism |
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Venous thrombosis of the leg and pulmonary thromboembolism |
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Venous thrombosis of the leg and pulmonary thromboembolism |
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Infective endocarditis |
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Infective endocarditis |
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Infective endocarditis |
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Infective endocarditis |
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Infective endocarditis |
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Infective endocarditis |
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Infective endocarditis |
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Liver Cirrhosis replacement of liver tissue by fibrosis (scar tissue) and regenerative nodules |
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Liver Cirrhosis replacement of liver tissue by fibrosis (scar tissue) and regenerative nodules |
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Liver Cirrhosis replacement of liver tissue by fibrosis (scar tissue) and regenerative nodules |
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Liver Cirrhosis replacement of liver tissue by fibrosis (scar tissue) and regenerative nodules |
Appendicits dilated vein, leukocyte margination | |
appendicitis exudate | |
appendicitis exudate | |
appendicits, irritation of capillaries-hyperemia, exudate | |
serous inflammation viral inflammation of intestine, hyperemia, dilated veins, edema in glands, cellular infiltrate | |
fibrinous inflammation fibrinoid necrosis (pink circle), | |
active inflammation PMN (small dark points), macrophages, exudate | |
acute bronchitis, exudate in lumen | |
actue superlative inflammation, acute bronchitis, hyperemia, exudare | |
hemorrhagic inflammation, crescentic and necrotizing glomerulonephritis | |
hemorragic inflammation, hyperemia, macrophages, exudates | |
hemorrhagic inflammation | |
acute inflammation, swelling of cells, PMN&neutrophils and plasma cells, no fibrosis | |
acute inflammation edema, not bacterial, no fibrosis, mononuclear cells (lymphocytes) | |
chronic active inflammation, fibrosis, tubulitis, | |
chronic active inflammation | |
granuloma capsule, giant cells | |
granulomatous disease, TB, necrotizing granulomas | |
margination, dilated vessel, RBC in center, show PMN | |
temporal arteritis, giant cells, fibrosis of artery wall, lymphocytes (small dots) | |
lung biopsy HE staining | |
HE | |
non-necrotizing granulomas, MMN | |
foreign body giant cell, langerhans giant cell | |
anthracosis | |
lymph node biopsy | |
lymph node biopsy | |
lymph node biopsy | |
chronic cholecystitis | |
cirrhosis | |
chronic cholecystitis | |
lymphoid follicule | |
stomach biopsy | |
PMN, MMN, inflammation | |
intestinal metaplasia |
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