11977453
Beschreibung
Mindmap von Gelöschter Nutzer, aktualisiert more than 1 year ago
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Erstellt von Plymouth Med
vor fast 7 Jahre
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Kopiert von Plymouth Med
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Acquired Immunity: Cell-med and Humoral
- Antigen Presenting Cell arrives at Lymphnode
- APC
- MHC
II
- Antigen
- TCR
- immature
CD4+ T
helper cells
- Differentiation
Maturation
- Mature CD4+ THI
cells
- Bring over
CD8+ T cells
- mature
CD8+ T
cells
- mature
CD8+ T
cells
- TCR
- TCR
- mature
CD8+ T
cells
- mature
CD8+ T
cells
- IL 2
- INF-gamma
- INF-gamma
- further macrophage activation
- production of IL-1
- helps with epithelial rolling
- helps with epithelial rolling
- releases reactive oxygen species
- Bring over
CD8+ T cells
- Mature CD4+ THI
cells
- Differentiation
Maturation
- immature
CD4+ T
helper cells
- TCR
- IL 2
- INF-gamma
- MHC I
- A
- mature
CD8+ T
cells
- Infected Cell
- MHC I
- A
- Release of
Cytotoxic
Granule
- Granzyme
- Perforin
- Punches Holes in
cell's exterior
- Punches Holes in
cell's exterior
- Enzyme that messes
up cell's interior
- Perforin
- Granzyme
- Release of
Cytotoxic
Granule
- A
- MHC I
- mature
CD8+ T
cells
- Activation of
"Death Sign
- FAS-FAS
Ligand
- Apoptosis
- Apoptosis
- FAS-FAS
Ligand
- Activation of
"Death Sign
- Infected Cell
- mature
CD8+ T
cells
- A
- MHC
II
- Cell Mediated Response
- Humoral Response
- APC
- MHC
II
- A
- TCR
- immature
CD4+ T
helper cells
- Differentiation
Maturation
- Mature CD4+ TH II Cells
- IL 5
- B cell maturation
- Plasma B cells
- Undergoes Class Switch
- Early stages of infection
- mainly IgM
- Innate antibody
- Very nonspecific
- Pentamer
- Pentamer
- BCR
- IgD
- IgM
- Can accept antigen and
trigger release of chemokine
same way APC will
- EARLY STAGES: IgM
- IgM will act as a BCR and trigger
- OR
- cause class switch
- b/c chemokine cause clonal selection and clonal expansion
- b/c chemokine cause clonal selection and clonal expansion
- cause class switch
- APC will trigger
- IgM will act as a BCR and trigger
- EARLY STAGES: IgM
- IgD
- Innate antibody
- Later stages of infection
- mainly IgG
- specific antibody
- Transplacental
- Clumps and neutralizes pathogens
- specific antibody
- mainly IgG
- mainly IgM
- Early stages of infection
- produces the
antibodies
- Undergoes Class Switch
- Memory B cells
- stores
antibodies in
case of second
exposure
- stores
antibodies in
case of second
exposure
- Memory T
cells
- Plasma B cells
- B cell maturation
- IL 10
- inhibits maturation and
proliferation after a while
- inhibits maturation and
proliferation after a while
- IL 4
- Clonal Selection
- Clonal Expansion
- Clonal Selection
- IL 5
- Mature CD4+ TH II Cells
- Differentiation
Maturation
- immature
CD4+ T
helper cells
- TCR
- A
- MHC
II
- cannot happen without cell mediated
- APC
- APC
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