Zusammenfassung der Ressource
Systemic Lupus Erythematosus
- most common in women
- not seen in before age 5 to pre adolescents
- Multi system Autoimmune
- Inflammation of Blood Vessels and Connective Tissue
- Complement system - protects from infection about 30 protiens, initiate, acquired, inflammation immune system
- increase Anti DsDNA antibodies => decrease complement
- decrease ant DsDNA antibodies => increase
complement
- Insidious Vs. Acute
- 11 Criteria Need 4 out of 11 to Diagnose
- SOAP BRAIN MD
- Serotitis- Pleuritis, Pericarditis
- Oral Ulcers
- Arthritis - non erosive, once treated goes away
- Photosensitivity
- Blood= all are low
- Renal = Protein - 24 hour urine 400-500mg/ 24 hours need to do Kidney Biospy 75 % of kids
- Neurologic - psyc, seizures, Headache, stroke
- Malar Rash
- Discoid Rash- slightly elevated pink flakes crust scalp outer ear never on lips
- Immunologic DsDNA
- AnA
- Coronary Artery Disease
- Sjogren SYndrome= Carotids, dry eyes and mouth
- Raynauds
- Clotting problems= lupus anticoagulant puts risk clots add baby asspirn
- Infections- Flu, Pneumonococcal, Meningococcal
- Monitor
- Dexo Scan
- Eye Exam- planqueniol= leaves deposits in eyes Prednisone increase eye pressure cataracts
- EKG/Chest X ray Yearly
- TSH+ if have one autoimmune system may have anothe r
- Lipids Homocysteine - coronary artery disease
- Clotting studies- PT, PTT, LAC antiphopholipids
- 24 hour Urine- 24 hour protein, 24 Creatinine, Creatinine Clearance, EVERY 6 Months
- Osteoporosis
- Treatment
- Prednisone
- Methylprednisone
- Baby ASA
- Anti HTN Nephritis
- Hydroxychloroquinel- anti malaria= plaquenil
- Photoprotection
- Mycophenonate= cellcept Myfortic Cytoxan IV pulsing Immune Suppressant