Zusammenfassung der Ressource
Peripheral vascular diseases
- Blood vessels of the lower limbs
- Arteries
- Veins
- Vasculitis
- Large vessels
- Giant cell
(temporal
arteritis)
- Elderly
female,
headache, jaw
claudication
- Could lead to blindness (ophthalmic artery)
- Takayasu arteritis
- Asian young female
- Pulseless disease, fever, night sweats
- Medium vessels
- Polyarteritis
nodosa
- Kawasaki
disease
- Buerger disease
- Heavy smoker, young male
- Gengrene, autoamputation of digits
- Asian children less than 4 years
old, affecting skin, lips, tongue
- Middle-aged men, Hep B in
30%, immune mediated
- Nerves, skin, kidneys
- Small vessels
- Wegener
- Microscopic
polyangiitis
- Churg-Strauss
- Henoch-Schonlein purpura
- Most common childhood systemic vasculitis
- Classic triad: palpable purpura, arthralgia, GI problems
- Asthma in adults,
pouch-immune
- p-ANCA positive, high IgE levels
- Eosinophilia
- Similar to
Wegener but no
granuloma or
nasopharungeal
involvement
- p-ANCA positive
- affecting both
upper and lower
respiratory
tracts
- c-ANCA positive
- Atherosclerosis
- Risk factors
- Tobacco
smoke
- Hereditary
- Endocrine
- Obesity
- Males
- Age
- Stress
- Pathogenesis
- endothelial cell dysfunction
- macrophage and LDL accumulation
- Foam cell formation
- fatty streaks
- smooth cell migration
- proliferation
and
extracellular
matrix
deposition
- fibrous
plaque
- complex
atheroma
- Intermittent
claudication
- A symptom of
PAD
characterized by
pain, aching, or
fatigue in
exercising leg
muscles
- Aortic dissection
- Intimal tear
with dissection
of blood
through media
of the aortic
wall
- Aneurysms
- Thoracic
- compression
of
mediastinal
structures
- Abdominal
- Primarily due to atherosclerosis
- Investigations
- ABI index
- Duplex US
- photoplethysmogram
- Management
- Smoking cessation
- Excersice
- Statins
(anti-heperlipidemics)