Zusammenfassung der Ressource
gout
- Classification and staging
- GoutChronic Disease- in 4 Stages (natural history)
- Risk factors
- Alcohol... Diet...
Genetics... Gender...
Age... Medications...
Obesity... Medical
- Alcohol and gout
- inhibit uric acid secretion and increase urate production
- Causes of Gout
- Causes of Increased Source or Production
- Causes of Increased Source or Production
- Consumption
- Anchovies, sardines, kidney, liver, and red-meat, fructose-sweetened drinks
- Cell lysis & turnover
- myeloproliferative & lymphoproliferative disorders
- Genetic disorders:
- HGPRT deficiency (Lesch-Nyhan syndrome)
G6PD (von Gierke disease)
- Causes of Decreased Elimination
- Renal insufficiency or Medullary cystic KD
- Thiazide diuretics, Niacin, Aspirin, Cyclosporine, Pembrolizumab
- GLUT9 gene ↔ Solute Carrier 2A9 (SLC2A9) [↑ reabsorption of urate]
- What about causes of Pseudogout?
- Hyperparathyroidism
Hemochromatosis
Etidronate disodium
therapy Angiography
- Signs & symptoms
- Podagra... Tophi... Swollen
inflamed joint... Limited ROM
- Complications of gout
- Treatment
- Acute gouty arthritis
- NSAIDs
Corticosteroids
Colchicine
- Hyperuricemia in gout
- Allopurinol