Zusammenfassung der Ressource
Sickle Cell Anemia
- change in one nucleotide
- changes entire amino acid sequence
- changes structure of protein
- changes shape of red blood cell (sickle shape)
- protein misfolding
- some hydrophobic amino acids could be displayed on surface
- changes cell function
- inherited
- protein aggregation
- because of misfolding they clump together
- malaria
- one sickle cell mutation and one non mutated gene
- resistant to malaria