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Glycogen Phosphorylase Structure (Without Phosphorylation)

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Year 2 Mindmap am Glycogen Phosphorylase Structure (Without Phosphorylation), erstellt von gina_evans0312 am 23/10/2013.
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Mindmap von gina_evans0312, aktualisiert more than 1 year ago
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Erstellt von gina_evans0312 vor etwa 11 Jahre
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Zusammenfassung der Ressource

Glycogen Phosphorylase Structure (Without Phosphorylation)
  1. T Form
    1. Inactive- Active site it buried within protein
      1. Caused by
        1. High ATP
          1. High glucose-6-phosphate
            1. Glucose (In the liver)
        2. R Form
          1. Active- Active site is acessable to glycogen
            1. Caused by
              1. AMP
                1. Pi
                  1. Phosphorylation
              2. Interface domain
                1. Contains allosteric effector site
                  1. Where ATP/AMP binds
                2. Active Site
                  1. Found in deep groove to prevent water entering
                    1. Entrance of water causes hydrolysis instead of phosphorylysis
                      1. Made of
                        1. Glycogen Storage
                          1. Interface
                            1. And C Terminus Domains
                            2. This deep groove is what causes the steric hinderence during cleavage
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