Zusammenfassung der Ressource
Pathway to muscle contraction
- 1. Nerve impulse depolarizes the nerve terminal
- 2. Votlage gated Ca2+ channels open
- 3. Ca2+ enters the nerve terminal
- 4. Vesicles of Ach exit the nerve terminal via exocytosis
- 5. Ach binds to the ACh receptor at two sites of ACh receptor.
- 6. Influx of Na+ causes depolarisation of the myocyte membrane. The Na+ enters through the ACh receptor
- 7. This opens voltage gated Na+ and Ca2+ channels
- 8. Then Ca2+ is realesed from SR into the cytosol of myocyte which causes muscle contraction
- 9. Acetylcholinesterase – anchored to the post-synaptic membrane terminates synaptic transmission