Zusammenfassung der Ressource
Smooth Muscle Contraction
- Alpha 1 Receptor (PIP2 --> IP3)
- IP3 releases Ca2+ from Sarc. Ret
- Ca2+ can enter the cytoplasm
through voltage/ligand gated
channels
- Ca2+ binds to calmodulin
- Interacts with myosin light chain kinase which P myosin head groups and stimulates contraction
- B receptors inhibit
Myosin Light Chain
Kinase
- By activating PKA (though cAMP