Zusammenfassung der Ressource
Transplantation
- Transplantable tissues
- Skin
- Kidnney
- Liver
- Heart
- Lung
- Pancreas
- Cornea
- Bone Marrow
- Face
- Types
- Autograft
- Allograft
- Isograft
- Xenograft
- Problems
- Antibodies
- Hyperacute rejection
- Alpha1-3Gal
- transgenic pigs?
- Complement
- PERVS
- Matching
- MHC
- MLR
- ABO
- Graft rejection
- Types
- Hyperacute
- ABO missmatch
- Pre existing antibodies
- Acute
- MHC missmatch
- Chronic
- T cell response
- Direct/indirect allorecognition
- Minor H antigens
- MHC I
- Polymorphic self proteins
- GVHD
- Immunosuppresive drugs
- Cyclosporin A
- Tacrolimus
- Blocks calcineurin
- dephosphorylation of NF-AT blocked
- IL-2 blocked
- Sirolimus
- Binds mTOR
- Prevents cell cycle in t cells
- Side effects
- Other drugs
- Prednisone
- Azathioprine
- Anti-CD3 antibodies
- siRNA
- Tregs