Zusammenfassung der Ressource
Hemolytic Anemias
- Intravascular hemolysis
- Paroxysmal nocturnal hemoglobinuria
- Missing CD55 and CD59
- Positive Ham's test
- Autoimmune hemolytic anemia
- Mechanical destruction
- Extravascular hemolysis
- Hereditary spherocytosis
- Ankyrin
- Spectrin
- Increased MCHC and RDW
- Splenomegaly
- Aplastic crises due to parvovirus B19
- Osmotic fragility test
- Splenectomy
- G6PD deficiency
- Sensitive to oxidative stress
- Sulfa drugs
- Fava beans
- Infections
- Heinz bodies
- Pyruvate kinase deficiency
- RBCs cannot generate ATP
- Swelling and hemolysis of the red cells
- Sickle cell disease
- Low oxygen tension
- Dehydration
- Complications
- Sequestration crisis
- Autosplenectomy
- Salmonella osteomyelitis
- Aplastic criss due to parvovirus B19
- Pain crises due to vasoocclusion
- Renal papillary necrosis due to hypoxemia
- Treatment
- Hydroxyurea
- Bone marrow transplantation
- Hemoglobin C disease
- Heterozygous: asymptomatic
- Homozygous: mild hemolysis and splenomegaly
- SC disease
- Warm agglutinins (IgG antibodies)
- Lupus
- CLL
- Drugs
- Cold agglutinins (IgM antibodies)
- CLL
- Mycoplasma infections
- Infectious mononucleosis