Zusammenfassung der Ressource
A viral
infection
- HIV
- Structure
- retrovirus
- stages
- primary infection
- 1 to 3 months
- includes window period
- period between infection
and production of
antibodies
- 4 to 8 weeks
- highly infectious person
- HIV RNA copies are
very high, CD4 count is low
- CD4 count 800-1500/ml
- clinical latency
- CD4 count increases,
HIV RNA copies
decrease
- 8 to 10 years
- asymtpomatic period
- AIDS
- 2 to 3 years
- CD4 count less than 200/ml
- immune system weakens
- prone to opportunistic
infections and
malignancies
- kaposi sarcoma
- Tuberculosis
- meningitis
- candidiasis
- modes of transmission
- Sexually
- most common
- parentrally
- unsafe blood
- drug addicts
- mother to child (vertical transmission)
- in utero
- during birth
- breast milk
- prevention
- health education
- safe sex
- sterilised needles
- ART for pregnant HIV+ women
- screening of organs and
blood donors
- investigations
- test for
- viral infection
- viral load
- PCR test
- quantitation of viral load
- positive in first 10 days
- p24 antigen
- useful for
window
period
- immune response
- immunoglobulins
- cellular response
- 2 steps
- confirmatory tests
- western blot
- immunofluorescense
- screening tests
- ELISA
- latex agglutination
- management and
follow up
- antiretroviral therapy
- protease inhibitor
- inhibits action of HIV
aspartyl protease
- entry/fusion inhibitor
- inhibits fusion and entry of
virus to target host cell
- reverse
transcriptase
inhibitor
- NRTIs
- NNRTIs
- inhibits formation of
DNA from Viral RNA
- integrase inhibitor
- inhibits integration of viral
cDNA to host DNA
- follow up
- virologic failure
- therapeutic drug monitoring
- cd4 cell recovery
and persistent
inflammation
- stages of grief
- denial
- anger
- bargaining
- depression
- acceptance