Pharmokinetics of Opioids

Absorption: absorbed well orally, as inhailants & transdermally Distribution: highly protein boundMetabolism: undergoes first pass in liver which reduces bioavailabilityExcretion: as metabolites via kidneys (urine)Uses:        -analgesia- alter reaction to pain stimuli       -sedation and anti-anxiety through kappa receptors       -cough suppression        -a

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