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419785
Autonomic Drugs & ANS
Description
300 level PHARM 325 Mind Map on Autonomic Drugs & ANS, created by fandrickb2 on 05/12/2013.
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pharm 325
pharm 325
300 level
Mind Map by
fandrickb2
, updated more than 1 year ago
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fandrickb2
over 10 years ago
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Resource summary
Autonomic Drugs & ANS
Cholinergics (Stimulate PANS-Ach): low HR, Inc. GI motility, miosis, dec. IOP (eye), inc. saliva bronchioconstriction
Direct Acting
Direct Acting on Nicontinic Receptors
Nicotene, Nicorette, Varenicline, Champix (smoking cessation)
Direct acting on muscarinic receptors
Pilocarpine (glaucoma &xerostomia)
Bethanechol (Tx incomplete emptying of bladder/urinary retention)
Indirect (inhibit the enzyme that destroys ACH) Cholinesterase inhibitors
Donepzil, Aricept, Galantamine, Reminly ER (Tx Alzheimers by inc. Ach in brian)
Neostigmine (Tx myasthenia gravis)
Physostigmine (glaucoma)
Indirect & Irreversible: Organophosphates for pesticides & used in chemical warfare.
ADR: large doses affect SLUD, neuromuscular paralysis, effects on CNS (confusion)
Contraindications: athsma, hyperthyroidism, GI/UT obstructions, ulcers. Watch for orthostatic hypotension.
Anticholinergics: Inhibit PANS/release of Ach, block both muscarinic & nicotinic receptors.
ADR: xerostomia, blurred vision, photobpobia, high HR, constipation, dialates pupils.
Contraindications: cardiac disease, myasthenia gravis (Ach not produced), ulcers, glaucoma
Belladonna alkaloids: atropine, dialation of eyes
Scopolamine: slow GI/motion sickness
Ipratropium: bronchioconstriction
Dicyclomine: GI relaxation
Propantheline: dec stomach acid.
Adrenergic Agonists: SANS, NE/EPI
Alpha Agonists(NE has greater affinity than EPI)
Alpha 1: contracts smooth muscle of BV, bladder, sweat, eyes, glands, Gi
Eye decongestants, nasal mucosa(dec. secretions), vasoconstricts <3 muscle to inc BP, prolongs action of LA/dec bleeding (EPI)
A2: Autoreceptors: FEEDBACK, inhibit NE, decrease BP, insulin & eye secretion
Beta Agonists
B1: stimulation on <3: inc HR & contractility
B2: EPI most potent, NE doesnt really work here: relaxs lungs, bronchodialation, uterine contractions, vascular smooth muscle.
Athsma (salbutamol, albuterol, terbutaline, metaproterenol
non-selective B1&2: EPI (LA &Tx of anaphalaxis), isopropernol (athsma)
Dopamine: receptors primarily in SANS, an inhibitory NT, balances Ach in vascular smooth muscle.
Serotonin: produced in platelets, cells in GI & neurons. Controls sleep, pain & emotions.
Adrenergic Antagonists: drugs usually to Tx urinary retention, migranes & glaucoma. Block SANS so PANS response more prevalent
Direct
A1: produces vasodialation to Dec. BP
A2: keeps SANS turned on
B2: cardioselective: betal blockers "olol" atenolol better than propranolol bc of less SE.
Indirect
doesnt act on adrenergic receptors but blocks NE so no SANS response, will Tx hypertension.
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