Hodgkin Lymphoma

Lymphomas - malignant tumors of:  Primary lymphoid tissue (thymus)  Secondary tissue (lymph nodes, spleen, tonsils)

Pathophysiology:Abnormal chromosomes present in cells of lymph nodes. - Reed-Sternberg cell (RS cells) - not specific to HLUsually arises in a single nodeMolecular mechanisms causing malignant transformation of cells are unclear - Viruses, genetic factors

Clinical Manifestations:1st sign: enlarged unilateral painless swelling or mass in neck.CXR shows mediastinal massEnlargement of cervical, axillary & inguinal lymph nodes common.Fever / sweating / weight loss

Diagnosis:May be difficult due to variety of symptoms.CXR, biopsy, lymphangiographyIdentify stage once diagnosis made

Treatment:Cure possible regardless of stage (75% success rate).Chemotherapy.Radiation therapy.HIgh dose chemo w/ BM or stem cell transplant (latest Tx option)

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