General Pathoanatomy Final MCQs (301-400)- 3rd Year- PMU

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General Pathoanatomy Final MCQs (301-400)- 3rd Year- PMU
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Frage 1

Frage
Indicate the correct statement(s)
Antworten
  • granulation tissue is rich of capillaries and cells
  • granulation tissue is rich in collagen fibres and fibroblasts and contains less blood vessels
  • granulation tissue is the immature connective tissue
  • fibrous tissue is immature connective tissue

Frage 2

Frage
What is hyper-granulation?
Antworten
  • mature connective tissue
  • hypertrophic tumor-like cicatrix/scar
  • greater amount of granulation tissue
  • none of the above

Frage 3

Frage
What is a scar?
Antworten
  • hypertrophic granulation tissue
  • mature connective tissue
  • hypertrophic tumor-like cicatrix
  • none of the above

Frage 4

Frage
What is a keloid?
Antworten
  • hypertrophic tumor-like cicatrix
  • mature connective tissue
  • greater amount of granulation tissue
  • none of the above

Frage 5

Frage
Which stain can be used to prove of scarring (cicatrix) of the heart?
Antworten
  • Van Gieson
  • Peris
  • Congo Red
  • PAS

Frage 6

Frage
Which of the could not be seen in rheumatoid nodules?
Antworten
  • Fibrinoid necrosis
  • Epitheloid cells
  • Langhans cells
  • Lymphocytes

Frage 7

Frage
Indicate the correct statement(s) for the polyarteriitis nodosa.
Antworten
  • it is an autoimmune disease
  • it affects mostly the elastic arteries
  • there is accumulation of glucosaminoglycans in the vessel walls which can be demonstrated with metachromasia with Toluidin Bleu
  • the branches of the pulmonary arteries are affected

Frage 8

Frage
Anaphylactic hypersensitivity reactions are related to:
Antworten
  • Hemolytic anemia
  • Hashimoto thyroiditis
  • Allergic rhinitis
  • Bronchial asthma

Frage 9

Frage
Cytotoxic hypersensitivity reactions are related to:
Antworten
  • hashimoto thyroiditis
  • hemolytic anemia
  • allergic rhinitis
  • nodosal poyarteriitis

Frage 10

Frage
Immune complexes mediated hypersensitivity reactions are related to:
Antworten
  • polyartheriitis nodosa
  • rheumatoid arthritis
  • hemolytic anemia
  • tuberculosis

Frage 11

Frage
Cell mediated hypersensitivity reactions are related to:
Antworten
  • Tuberculosis
  • Polyarteriitis nodosa
  • Bronchial asthma
  • Hashimoto thyroiditis

Frage 12

Frage
Indicate characteristics of the benign tumors.
Antworten
  • expansive type of growth
  • fast speed of growth
  • invading and destroying the adjacent tissues
  • in general they have good prognosis

Frage 13

Frage
Indicate characteristics of the benign tumors
Antworten
  • infiltrative growth
  • slow, long term developntcnt
  • usually they don't recur after complete surgery
  • their microscopic structure shows only tissue atypia

Frage 14

Frage
Indicate correct characteristics of the malignant tumors.
Antworten
  • expansive growth
  • fast speed of growth
  • they have poor prognosis in general
  • composed of differentiated, mature cells

Frage 15

Frage
Indicate correct characteristics of the malignant tumors.
Antworten
  • infiltrative growth
  • microscopic structure shows both tissue and cells atypia
  • good prognosis in general
  • metastasizing

Frage 16

Frage
Which is the most common way of metastasizing of epithelial tumors?
Antworten
  • by lymphatics (lymphogenic metastases)
  • with blood (hematogenic metastases)
  • by cerebrospinal fluid
  • none of the above

Frage 17

Frage
What is papilloma?
Antworten
  • malignant tumor of the covering epithelium
  • benign tumor of glandular epithelium
  • benign tumor of cover type epithelium
  • benign soft tissue tumor

Frage 18

Frage
Indicate the correct characteristic(s) for papilloma
Antworten
  • it has tree-like stroma covered by differentiated stratified squamous epithelium
  • it has tree-like stroma covered by undifferentiated squamous epithelium with signs of cell atypia
  • stroma and parenchyma are difficult to distinguish
  • it doesn't have a capsule

Frage 19

Frage
What is the term used for malignant tumors of cover type epithelium?
Antworten
  • adenocarcinoma
  • papilloma
  • carcinoma
  • sarcoma

Frage 20

Frage
What is the term used for malignant tumors of glandular type epithelial origin?
Antworten
  • adenocarcinoma
  • adenoma
  • carcinoma
  • carcino-adenoma

Frage 21

Frage
What is the term used for benign tumors of glandular type epithelial origin?
Antworten
  • papilloma
  • adenoma
  • teratoma
  • adenocarcinoma

Frage 22

Frage
Point the correct statement(s) about basal cell carcinoma.
Antworten
  • it develops only on the skin
  • it can develop at any place with squamous epithelium
  • it characterizes with early lymphogenic and hematogenic metastases
  • very often it recurs at the same place after surgery

Frage 23

Frage
Keratinized squamous cell carcinoma:
Antworten
  • develops only on the skin
  • can develop at any place with squamous epithelium
  • is highly undifferenciated malignant tumor
  • is a tumor composed of more differenciated cells with keratin production

Frage 24

Frage
What kind of structures are the cancer perls?
Antworten
  • accumulation of keratin produced by more differentiated malignant cells originating from squamous epithelium
  • pink-coloured homogenous substance located in the centre of the tumor nests
  • accumulation of mucus produced by highly undifferentiated malignant cells located in the centre of the tumor nests
  • pink homogenous substance that accumulates in the stroma of the tumor

Frage 25

Frage
The gross appearance of which tumor is called "ulcus rodens"?
Antworten
  • squamous cell carcinoma
  • melanoma
  • basal cell carcinoma
  • adenocarcinoma

Frage 26

Frage
Squamous cell carcinoma develops in the lung after:
Antworten
  • acute bronchitis
  • chronic bronchitis accompanied by metaplasia
  • bronchial asthma
  • inhalaton of a foreign body

Frage 27

Frage
Indicate the correct microscopic features of cell atypia
Antworten
  • polymorphism of cells and nuclei
  • low nucleus-cytoplasm index
  • typical mitoses
  • monster cells, hyperchromasia and polychromasia of nuclei

Frage 28

Frage
What are the characteristics of the nuclei of the malignant tumors?
Antworten
  • polychromasia
  • normal staining pattern
  • hyperchromasia
  • increased nucleo-cytoplasmic index

Frage 29

Frage
Papillary carcinoma of the urinary bladder arises from:
Antworten
  • squamous epithelium
  • transitional epithelium
  • glandular epithelium
  • smooth musculature

Frage 30

Frage
What is carcinoma in situ?
Antworten
  • malignant tumor limited to the epithelium above the basal membrane
  • malignant tumor destroying the basal membrane but spreading no more than 5mm below it
  • benign tumor limited to the basal membrane
  • benign tumor of a great size compressing the surrounding tissues

Frage 31

Frage
What type of atypia could be seen in the benign tumors of glandular epithelium?
Antworten
  • tissue atypia
  • cell atypia
  • both tissue and cell atypia
  • none of the above

Frage 32

Frage
Which staining is used for proving mucus production from gelatinous adenocarcinoma?
Antworten
  • Congo red
  • Toluidin bleu, metachromasia is demonstrated
  • PAS reaction with amylase control
  • Van Gieson

Frage 33

Frage
Pericanalicular and intracanalicular are types of:
Antworten
  • Ductal carcinoma of the breast
  • Paget's disease
  • Renal cell carcinoma
  • Fibroadenoma

Frage 34

Frage
Kruckenberg tumors are:
Antworten
  • metastases from colon adenocarcinoma in the ovaries
  • metastases from pancreatic adenocarcinoma in the ovaries
  • metastases from gastric carcinoma in the ovaries
  • metastases from hepatocellular carcinoma in the ovaries

Frage 35

Frage
Pleomorphic adenoma could be seen mainly:
Antworten
  • in the parotid gland
  • in the minor salivary glands
  • in the stomach
  • in the thyroid gland

Frage 36

Frage
Indicate the correct statements about fibroadenoma of the breast.
Antworten
  • capsulated and lobulated tumor
  • non-capsulated malignant tumor with invasive growth
  • microscopically it has two types -- intracanalicular and pericanalicuJar
  • seen in older women

Frage 37

Frage
Mark the correct statements about papillary cystadenoma of the ovary:
Antworten
  • malignant tumor
  • has cyst-like and papillary structures
  • histological characteristics include serous and mucinous types
  • it is a physiological change related to menstrual cycle

Frage 38

Frage
'Linitis plastica' is a gross subtype of:
Antworten
  • gastric cancer
  • pancreatic cancer
  • breast cancer
  • uterine cancer

Frage 39

Frage
Grossly adenocarcinoma of the colon can be:
Antworten
  • polypoid
  • ulcerous
  • nodular
  • all of the listed above

Frage 40

Frage
The terms "early cancer" and "advanced cancer" are used for:
Antworten
  • gastric adenocarcinoma
  • adenocarcinoma of the endometrium
  • adenocarcinoma of the colon
  • breast cancer

Frage 41

Frage
Malignant tumors from soft tissue are called:
Antworten
  • carcinomas
  • word for tissue origin+ suffix " —oma"
  • sarcomas
  • teratomas

Frage 42

Frage
Indicate the characteristics of the sarcomas.
Antworten
  • seen in older age
  • grossly they look like "fish meat"
  • they give early hematogenic metastases
  • parenchyma and stroma are equally distributed

Frage 43

Frage
Mark the characteristics of the carcinomas.
Antworten
  • seen in young people
  • they metastasize by the blood flow first
  • grossly they have granular surface
  • parenchyma and stroma are equally distributed

Frage 44

Frage
What kind of sarcoma could be seen in an immune deficiency?
Antworten
  • Kaposi sarcoma
  • Ewing sarcoma
  • Rhabdomyosarcoma
  • Chondrosarcoma

Frage 45

Frage
Which of the following sarcomas have the worst prognosis?
Antworten
  • liposarcoma
  • ostesarcoma
  • fibrosarcoma
  • leiomysarcoma

Frage 46

Frage
What staining can be used to distinguish leiomyoma uteri from fibroma?
Antworten
  • Congo red
  • Perls
  • PAS reaction with PAS control
  • Van Gieson

Frage 47

Frage
Point the characteristics of the leiomyosarcoma.
Antworten
  • polymorphism of cells and nuclei
  • hyper- and polychromasia of nuclei
  • typical mytoses
  • monster cells

Frage 48

Frage
What is hybernoma?
Antworten
  • benign tumor of vascular origin
  • benign tumor originating from brown fat tissue
  • benign tumor originating from striated muscles
  • malignant tumor originating from pigment tissue

Frage 49

Frage
What are the signs of the atypia in a nevus?
Antworten
  • asymmetry of the lesion, irregular borders
  • dark color, irregular color of the lesion
  • diameter less than 5mm
  • regular borders

Frage 50

Frage
How should a biopsy be done if there is a suspicion for the melanoma?
Antworten
  • incision biopsy
  • punch biopsy
  • excision biopsy
  • brush biopsy

Frage 51

Frage
Point the most common localizations of the teratomas.
Antworten
  • ovaries, testis
  • extremities
  • retroperitoneum
  • mediastinum

Frage 52

Frage
Which of the following are organoid teratomas
Antworten
  • nephroblastoma
  • cholesteatoma
  • dermoid cyst
  • branchiogcnic cyst

Frage 53

Frage
Which of the following is organismoid teratoma
Antworten
  • epidermoid cyst
  • teratocarcinoma
  • dermoid cyst
  • nefroblastoma

Frage 54

Frage
What is a nevus pigmentosus?
Antworten
  • tumor-like process
  • tumor process
  • microscopically it contains mature melanocytes
  • microscopically it contains cells with signs of severe atypia and some of them contain melanin

Frage 55

Frage
What is a melanoma?
Antworten
  • malignant congenital tumor
  • benign tumor composed of melanocytes
  • malignant tumor of pigment origin
  • none of the above

Frage 56

Frage
What is an achromatic melanoma?
Antworten
  • benign form of melanoma
  • melanoma without melanin in the tumor cells
  • type of melanoma which can be proved with immunohistochemical tests
  • melanoma which is more differentiated

Frage 57

Frage
Point possible localizations of the nevus pigmentosus and melanoma.
Antworten
  • skin
  • uvea
  • meninges
  • all of the above

Frage 58

Frage
Lentigo maligna, nodular, superficial, acral lentigenous are gross forms of:
Antworten
  • melanoma
  • squamous cell carcinoma of the skin
  • basal cell carcinoma of the skin
  • nevus pigmentosus

Frage 59

Frage
Indicate immunohistochemical stains to prove melanoma
Antworten
  • HMB-45
  • Ca-125
  • S-100
  • Cytokeratin

Frage 60

Frage
Which of the following tumors do not have a stroma
Antworten
  • choriocarcinoma
  • seminoma
  • nephroblstoma
  • neuroblastoma

Frage 61

Frage
Indicate types of nevus pigmentosus:
Antworten
  • acquired and congenital
  • junctional, compound, intradermal
  • benign and malignant nevus
  • ectodermal and endodermal nevus

Frage 62

Frage
Melanin is:
Antworten
  • lipidogenic pigment
  • proteinogenic pigment

Frage 63

Frage
Where is lipofuscin deposited?
Antworten
  • intracellularly
  • extracellularly

Frage 64

Frage
The frozen section ('gefrir') is:
Antworten
  • rapid 'intraoperative' histological diagnosis
  • rapid cytology method
  • type of medical imaging
  • histochemical method

Frage 65

Frage
The term „pathognomonic change" means:
Antworten
  • unexplained change
  • paradoxical change
  • sufficient to identify the diagnosis/lesion
  • diffuse inflammatory change

Frage 66

Frage
Most likely the cause of centrolobular fatty degeneration of hepatocytes is:
Antworten
  • diabetes
  • intoxication
  • hypoxia
  • overfeeding

Frage 67

Frage
Hyaline — droplet degeneration has following characteristics:
Antworten
  • extracellular
  • intracellular
  • protein accumulation
  • carbohydrate accumulation

Frage 68

Frage
What pigment is formed in the center of the hematoma?
Antworten
  • hemosiderin
  • lipofuscin
  • hemomelanin
  • hematoidin

Frage 69

Frage
In which blood vessels are formed most frequently mixed thrombi?
Antworten
  • large veins
  • arteries
  • capillaries
  • venules

Frage 70

Frage
Squamous cell carcinoma occurs most frequently in:
Antworten
  • stomach
  • skin
  • bladder
  • larynx

Frage 71

Frage
Hyperemic-hemorrhagic zone occurs in:
Antworten
  • tophi urici
  • nodular amyloidosis
  • anemic infarction
  • pneumonia

Frage 72

Frage
Which types of bleeding occur in the digestive system?
Antworten
  • hemothorax
  • hemoptysis
  • melena
  • hematemesis

Frage 73

Frage
Which of the following cell damages are irreversible?
Antworten
  • necrosis
  • apoptosis
  • vacuolar degeneration
  • cellular edema

Frage 74

Frage
Left ventricular hypertrophy can develop in:
Antworten
  • cor pulmonale
  • systemic hypertension
  • mitral stenosis
  • aortic stenosis

Frage 75

Frage
Cancer cells which show no resemblance to the tissue from which the tun originates are called:
Antworten
  • undifferentiated carcinoma
  • well-differentiated carcinoma
  • scirrhous type carcinoma
  • histioid cancer

Frage 76

Frage
Which of the following is correct for the mechanical jaundice?
Antworten
  • indirect bilirubin prevails in blood
  • elevated urine urobilinogen
  • elevated urine bilirubin
  • stools are hyperpigmented

Frage 77

Frage
Basal cell carcinoma is localized most frequently on:
Antworten
  • the skin of the forearm
  • the skin of the lower limbs
  • the skin on the palms
  • skin of the face

Frage 78

Frage
Caseous necrosis is characteristic for:
Antworten
  • specific inflammation
  • tuberculosis
  • enzyme fat necrosis
  • chronic pyelonephritis

Frage 79

Frage
Bilaterally, on the skin of the eyelids of a young woman are seen yellow nodules with the size of a grain of rice. What is it?
Antworten
  • xanthelasmas
  • nevus
  • efelides
  • hemosiderin deposition

Frage 80

Frage
Which of the following are protein accumulations?
Antworten
  • in the epithelial cells of renal tubules
  • russel bodies
  • bodies of Mallory
  • asteroid cells

Frage 81

Frage
Hemorrhagic infarction develops in:
Antworten
  • organs with end type arteries (end type blood supply)
  • blockage of arterioles
  • previous venous stasis
  • organs with double blood supply

Frage 82

Frage
How do we call the local depigmentation of the skin?
Antworten
  • vitiligo
  • hemosiderosis
  • albinism
  • ohronosis

Frage 83

Frage
What kinds of techniques are used for the detection of the lipids:
Antworten
  • freezing microtome
  • paraffin method
  • alcohol fixation
  • staining with Sudan Ill

Frage 84

Frage
The sequence of local structural changes in a disease is called
Antworten
  • sanogenesis
  • pathogenesis
  • tanatogenesis
  • morphogenesis

Frage 85

Frage
" Tiger Heart " is diagnosed when:
Antworten
  • subepicardial fat is increased
  • yellowish lines in the papillary muscles are seen
  • the interventricular septum is injured
  • infarcted area of the left ventricle in seen

Frage 86

Frage
Which of the following is correct for the mechanical jaundice:
Antworten
  • it is parenchymal jaundice
  • there is posthepatic occlusion
  • direct bilirubin is increased
  • it is also called hemolytic jaundice

Frage 87

Frage
The risks involved in fast draining of large quantities of acistes are:
Antworten
  • development of low oncotic pressure edema
  • bleeding into the abdominal cavity
  • massive arterial hyperemia in the abdominal vessels
  • hemodynamic collapse

Frage 88

Frage
"Mutilation" means :
Antworten
  • form of biological mutation
  • pendulum movement of the blood
  • zonal hair loss
  • self amputation of phalanges

Frage 89

Frage
It is true that :
Antworten
  • concentric hypertrophy is also called tonogenic
  • eccentric hypertrophy is myogenic
  • hypertrophy can be combined with hyperplasia
  • false type of hypertrophy is hyperplasia

Frage 90

Frage
Sources of fat embolism in the lung are
Antworten
  • the bone marrow in the long bones
  • subcutaneous fat
  • liver with fatty degeneration
  • ulcerated atherosclerotic plaque of the aorta

Frage 91

Frage
Which of these factors lead to nutmeg liver?
Antworten
  • short venous stasis
  • arterial hyperemia
  • chronic venous congestion
  • mitral stenosis

Frage 92

Frage
In the bronchi and nasal cavity may develop squamous cell carcinoma based on:
Antworten
  • hypoplasia
  • histological accommodation
  • anaplasia
  • metaplasia

Frage 93

Frage
Amyloid demonstates following characteristics:
Antworten
  • identified with Tioflavin S in fluorescence
  • shows metachromasia with Perls
  • identified with Congo rot in polarized light
  • ultrastructurally has fibrillary structure

Frage 94

Frage
Anaphylactic shock occurs in:
Antworten
  • hypersensitivity reactions cytotoxic type
  • response induced by immune complexes
  • atopic reactions
  • delayed type hypersensitivity

Frage 95

Frage
A basal cell carcinoma is localized most frequently on:
Antworten
  • the skin of the forearm
  • the skin of the lower limbs
  • the skin on the palms
  • the skin of the face

Frage 96

Frage
Reaction for Prussian blue is used for:
Antworten
  • tattoos
  • proof of bilirubin
  • proof of hemosiderin
  • in hemochromatosis

Frage 97

Frage
How could an air embolism be proved:
Antworten
  • in the presence of witnesses
  • autopsy in a bathtub
  • puncturing the right ventricle
  • puncturing of the left ventricle

Frage 98

Frage
Which enzymes are involved in a melanogenesis?
Antworten
  • hyaluronidase
  • tvrosinase
  • dopa oxidase
  • lipase

Frage 99

Frage
Infarctions of which organs could often lead to the death of the patient?
Antworten
  • renal infarction
  • infarction of the spleen
  • infarction of heart
  • cerebral infarction

Frage 100

Frage
In cancers with epithelial origin:
Antworten
  • cells are arranged in sheets, nests or cords
  • resemble 'fish meat'
  • metastasize primarily by blood
  • cells show atypia
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