12636098
Beschreibung
Quiz von Alannah McDonnell, aktualisiert more than 1 year ago
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Erstellt von Alannah McDonnell
vor fast 7 Jahre
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Frage 1
Frage
Oxygen can be toxic
Antworten
- True
- False
Frage 2
Frage
Which of theses are reasons that oxygen is essential?
Antworten
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Oxidation reactions
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Generation of ATP (oxidative phosphorylation)
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Detoxification reactions
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Anaerobic glycolysis
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Bio synthetic reactions
Frage 3
Frage
Why is oxygen classified as toxic?
Antworten
-
When it accepts single electrons it is transformed into highly reactive oxygen radicals than can damage things.
-
When it accepts double electrons it is transformed into highly reactive oxygen radicals than can damage things.
-
When it accepts single electrons it is transformed into non-reactive oxygen radicals than can damage things.
-
It takes part in unnecessary reactions
Frage 4
Frage
What do oxygen radicals damage?
Antworten
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Cellular lipids
-
Proteins
-
DNA
-
Glucose
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Starch
Frage 5
Frage
What are the major sources of primary ROS in the cell?
Antworten
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CoQ generates superoxide in ETC
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Respiration in lungs
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Oxidase, oxygenates and peroxidases
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Ionizing radiation
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Non-ionizing radiation
Frage 6
Frage
Where can evidence of free radical damage be seen?
Antworten
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>100 disease states
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<100 disease states
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>1000 disease states
Frage 7
Frage
Where is evidence of free radical damage in disease states described?
Antworten
-
As primary cause of the disease
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By enhancing complications
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In the lumen of cells
Frage 8
Frage
Superoxide and the hydroxyl radical Initiate lipid peroxidation in..
Antworten
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Cellular membrane
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Mitochondrial membrane
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Nuclear membrane
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ER membrane
Frage 9
Frage
Increase in membrane permeability due to radical-mediated damage leads to..
Antworten
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A further influx of ca2+
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Repair of the mtiochondria
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Ca2+ leaving the cell
-
Further escaping of radicals
Frage 10
Frage
Oxidation of nuclear and mitochondrial DNA results in ...
Antworten
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Strand breaks
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Various damages
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RNOS
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Influx of Ca2+
Frage 11
Frage
Disruption of the mitochondrial membrane may augment free radical damage
Antworten
- True
- False
Frage 12
Frage
Oxygen derived free radicals are a minor source of DNA damage
Antworten
- True
- False
Frage 13
Frage
The non-specific binding of Fe2+ to DNA...
Antworten
-
facilitates localized production of the hydroxyl radical
-
Can attack the deoxyribose backbone
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Can cause strand breaks
-
Will cause apoptosis
-
Can be protective
Frage 14
Frage
At high concentrations nitrogen combines with oxygen or superoxide to form reactive and toxic species which contain both N and O.
Antworten
- True
- False
Frage 15
Frage
RNOS’s are implicated in ...
Antworten
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Neurodegenerative diseases
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Chronic inflammatory diseases
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Hay fever
-
Alcoholism
-
Hunger
Frage 16
Frage
What are some of the consequences of high concentrations of NO during inflammation?
Antworten
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Inhibition of enzymes
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Mitochondrial lipid peroxidation
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Inhibition of ETC and energy depletion
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Single or double strand breaks in DNA
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Modification of bases in DNA
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