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15% of US population is >65 and 80% have at least one chronic condition.
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Signs that a psych issue may have organic etiology:
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Always remember to assess for safety: [blank_start]mobility[blank_end], [blank_start]fall risk[blank_end], [blank_start]driving[blank_end].
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Drugs that can cause hallucinations or psychosis:
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Levo-dopa
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Procainamide
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Estrogen
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Steroids
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ACE inhibitors
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• Drugs that can cause agitation:
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Drugs with extensive first pass effect may not be absorbed as well as those with phase II pathways in the elderly.
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The following are which type of drugs?
• Amiodarone
• Diazempam
• Chlodiazepoxide
• Clonazepam
• Lidocaine
• Haloperidol
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Hydrophilic drugs that build up in the leaner elderly.
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Lipophilic drugs that get increased in with increased adipose tissue.
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Protein-bound drugs that are increased in the elderly.
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What is an issue with Lithium in elderly?
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In prescribing SSRI's to the elderly, consider that:
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They may disguise organic conditions.
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They are only indicated for <65 years old.
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Decreased fat:muscle ratio can result in serotonin syndrome.
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Decreased plasma protein results in increased unbound, active drug.
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Increased renal clearance changes elimination of drugs in elderly.
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Risks of benzos with elderly:
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Common side effects of psychotropic drugs in elderly:
o General: [blank_start]Decreased CNS arousal[blank_end]
o Peripheral cholinergic blockade: [blank_start]Urination and constipation[blank_end]
o Central cholinergic blockade: [blank_start]Confusion and memory problems[blank_end]
o Alpha-adrenergic blockade and central pressor blockade: [blank_start]Orthostasis[blank_end]
o Dopamine blockade: [blank_start]Gait and movement[blank_end]
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Decreased CNS arousal
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Dementia
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Drooling and slurring words
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Urination and constipation
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Prolonged QTc
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Confusion and memory problems
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Orthostasis
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Increased HTN
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Gait and movement
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Auditory or visual hallucinations
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Benzodiazepines should be tapered very slowly in elderly clients, 10% per month for chronic users (> 1 month usage).
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Types of reversible dementias:
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Alcoholic and vascular dementias are irreversible.
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Risk factors for dementia:
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Treatments for Alzheimer’s disease:
Cholinesterase inhibitors: [blank_start]Donepezil, Rivastigmine, Galantamine[blank_end]
NMDA receptor agonist: [blank_start]Menantine[blank_end]
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Cogentin, Artane, Benadryl
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Donepezil, Rivastigmine, Galantamine
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Menantine
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Ecstacine