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Quiz von Alannah McDonnell, aktualisiert more than 1 year ago
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Erstellt von Alannah McDonnell
vor mehr als 6 Jahre
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Frage 1
Frage
What is normal GFR in adult humans?
Antworten
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100-125 ml/min
-
4500-6000 ml/min
-
1 - 2 ml/min
-
540 - 900 ml / min
Frage 2
Frage
What does glomerular ultra-filtrate consist of?
Antworten
-
water
-
small solutes
-
large solutes
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plasma
-
urine
Frage 3
Frage
Glomerular Ultrafiltrate is normally ...
Antworten
-
containing proteins
-
protein free
Frage 4
Frage
What does Regulated reabsorption of water and solutes allow for?
Antworten
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regulation of extracellular fluid volume
-
regulation of osmolality
-
regulation of acid base balance
-
homeostasis of whole body phosphate concentrations
-
homeostasis of whole body calcium concentrations
-
homeostasis of whole body potassium concentrations
Frage 5
Frage
Which of these are freely filtered but not reabsorbed?
Antworten
-
urea
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creatinine
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water
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salt
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proteins
Frage 6
Frage
Permselectivity = the restriction of the [blank_start]permeation[blank_end] of [blank_start]macromolecules[blank_end] across [blank_start]the glomerular barrier[blank_end] on the basis of [blank_start]molecular[blank_end] size, charge, and physical [blank_start]configuration.[blank_end]
Antworten
-
permeation
-
permeability
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macromolecules
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micromolecules
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the glomerular barrier
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bowmans space
-
molecular
-
atomic
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configuration.
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conglobulation.
Frage 7
Frage
Podocytes = [blank_start]specialized[blank_end], highly [blank_start]differentiated[blank_end] cells which line the [blank_start]outside[blank_end] of glomerular [blank_start]capillaries[blank_end] and thus face the [blank_start]Bowman's space[blank_end] and the primary [blank_start]urine[blank_end]
Antworten
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specialized
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common
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differentiated
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similar
-
outside
-
inside
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capillaries
-
vessels
-
Bowman's space
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glomerulus
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urine
-
urea
Frage 8
Frage
Podocytes have a ____ cell body
Antworten
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large
-
small
-
average sized
Frage 9
Frage
The diaphragm in the podocyte covers the...
Antworten
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filtration slit
-
fenestration
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foot process
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whole cell body
Frage 10
Frage
What type of collagen composes the backbone of the fibrous network in the glomerular basement membrane?
Antworten
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type 1 collagen
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type 2 collagen
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type 3 collagen
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type 4 collagen
Frage 11
Frage
What is the normal urine flow rate in adult humans?
Antworten
-
1 - 2 ml/min
-
100-125ml/min
-
540-900 ml/min
-
900-1500ml/min
Frage 12
Frage
What is the normal renal blood flow rate in adult humans?
Antworten
-
900-1500 ml/min
-
4500 - 6000 ml/min
-
540-900 ml/min
-
1-2 ml/min
Frage 13
Frage
What is the normal renal plasma flow rate in adult humans?
Antworten
-
540-900 ml/min
-
4500-6000 ml/min
-
900 - 1500 ml/min
-
1-2ml/min
Frage 14
Frage
what does the filtration fraction generally measure?
Antworten
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20-25%
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40-45%
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50-60%
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80-85%
Frage 15
Frage
Roughly how much primary urine is produced per day?
Antworten
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140L
-
200L
-
140ml
-
500L
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10L
Frage 16
Frage
Roughly how much filtered fluid is reabsorbed?
Antworten
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99%
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1%
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20%
-
50%
-
75%
Frage 17
Frage
Drag and drop the right answer. all answers match up with a space, there are none spare.
For the 0 options, the 00 is in the % column and the normal 0 is in the urine column)
Antworten
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17
-
0.63
-
0.5
-
12.9
-
125
-
33
-
1.4
-
0.128
-
0.06
-
0.0048
-
0.134
-
0
-
18
-
1.8
-
0.72
-
9.5
-
0.96
-
1
-
00
-
55
-
130
Frage 18
Antworten
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Proximal convoluted tubule
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glomerulus
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Glomerular capsule
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efferent arteriole
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blood flow
-
afferent arteriole
-
glomerular filtrate
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fenestrae
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podocyte
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capillary endothelium
Frage 19
Frage
Glomerular capillaries are __________
Antworten
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fenestrated
-
continuous
Frage 20
Frage
Endothelial cells _______ determine the permselectivity of the glomerular barrier.
Antworten
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do
-
do not
Frage 21
Frage
The endothelial cell coat has _________
Antworten
-
charge-selective properties
-
no charge-selective properties.
-
size selective properties
-
molecular weight selective properties
Frage 22
Frage
___________ density of fenestrae facilitates ___________ permeability
Antworten
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high, high
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low, low
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high, low
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low, high
Frage 23
Frage
Which of these are important components that contribute to the selective properties of the glomerular basement membrane barrier?
Antworten
-
ptoteoglycans such as agrin
-
ptoteoglycans such as perlecan
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glycoproteins
Frage 24
Frage
Where is the endothelial cell surface layer?
Antworten
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on the luminal side of the blood vessels
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on the fenestrated side of the blood vessels
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on the outside of the blood vessels
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within the glomerulus
Frage 25
Frage
What are the 2 components of the endothelial cell surface layer?
Antworten
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the glycocalyx
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the endothelial cell coat
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the endometrial cell jacket
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the caloglycax
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the glucose layer
Frage 26
Frage
Thye glycocalyx is the...
Antworten
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plasma-membrane-bound part of the layer
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the more loosely associated part of the layer
Frage 27
Frage
Thye endothelial cell coat is the...
Antworten
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more loosely associated part of the layer
-
plasma-membrane-bound part of the layer
Frage 28
Frage
*** The endothelial cell surface layer is composed of....
Antworten
-
negatively charged glycoproteins
-
glycosaminoglycans
-
membrane associated and secreted proteoglycans
Frage 29
Frage
drag and drop the substances along the graph in relation to where there relative permeability lies
Antworten
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H2O
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NaCl
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Glucose
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Inulin
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Myoglobin
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Hemoglobin
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Albumin
Frage 30
Frage
Filtration of solutes that are not reabsorbed serves as an ineffective mechanism for their excretion
Antworten
- True
- False
Frage 31
Frage
Which of these about polo trees are true?
Antworten
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Have long extending cytoplasmic foot processes
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Foot processes are separated by a filtration slit
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The filtration slit is 25-60nm wide
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The filtration slit is covered by a diaphragm
-
One of the proteins that make up the diaphragm is nephrin
-
Nephrin is very safe
Frage 32
Frage
When mutated, nephrin...
Antworten
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Causes massive leakage of protein
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Causes severe consequences for patients with congenital nephrotic syndrome.
-
Causes the diaphragm in the kidney to close
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Causes excess water to be absorbed
-
Causes alcoholism
Frage 33
Frage
The basement membrane allows free passage of neutral molecules up to...
Antworten
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6Kd MW (18A radius)
-
16Kd MW (8A radius)
-
12Kd MW (24A radius)
-
2A MW (7Kd radius)
Frage 34
Frage
Negatively charged pores restrict passage of .... molecules
Antworten
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Large
-
Small
-
Medium
-
Long
-
Short
Frage 35
Frage
In disease states, protein Irial may be due to loss of negatively charge selectivity or to increasing numbers of large size pores
Antworten
- True
- False
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