Frage 1
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Which of the following is a systemic sign of infection?
Antworten
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Pain
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Erythema
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Swelling
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Fatigue
Frage 2
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Which of the following does NOT directly determine the virulence of a microbe?
Frage 3
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The widespread necrosis of respiratory mucosa caused by an influenza infection often gives rise to:
Antworten
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Subclinical infections
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Primary infections
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Secondary infections
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Tertiary infections
Frage 4
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Which of the following bodily fluids would you expect to be sterile?
Antworten
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Blood
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Vaginal discharge
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Faeces
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Sputum
Frage 5
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That time during an infection when the infected person may experience a headache or fatigue and senses he or she is “coming down with something” is referred to as which of the following?
Antworten
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Subclinical
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Acute
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Prodromal
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Incubation
Frage 6
Frage
Which of the following is a local sign of infection?
Antworten
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Fever and leukocytosis
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Headache and anorexia
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Nausea, weight loss, and fatigue
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Pain, erythema, and swelling
Frage 7
Frage
What are culture and sensitivity tests used for?
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To provide a specific medium that supports maximum microbial growth
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To provide living host cells for microbes requiring such for replication
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To identify the causative microbe and the effective antimicrobial agent for it
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To determine the type of microbe present in a specimen
Frage 8
Frage
What does leukocytosis frequently indicate?
Frage 9
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Secondary immune deficiencies occur because of:
Frage 10
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A common symptom of individuals with immunodeficiency is:
Antworten
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Anaemia
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Recurrent infections
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Lots of allergies
-
Auto antibody production
Frage 11
Frage
Primary immune deficiencies occur because of:
Frage 12
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Immunodeficiencies may result in an increased risk of infections by normally harmless microorganisms. These infections are referred to as:
Antworten
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transient
-
pathogenic
-
opportunistic
-
virulent
Frage 13
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Which of the following is an effect of cytokines? They:
Antworten
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increase the rate of mitosis in tumors.
-
cause immediate pain.
-
activate and stimulate proliferation of B and T lymphocytes.
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destroy antigens quickly.
Frage 14
Frage
An incompatible blood transfusion is an example of this type of hypersensitivity reaction:
Antworten
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Type IV
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Type III
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Type II
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Type I
Frage 15
Frage
Reaction to latex gloves (in most cases) is an example of what type of hypersensitivity reaction:
Antworten
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Type IV
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Type III
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Type II
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Type I
Frage 16
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In this type of reaction, the antigen and antibody combine forming an immune complex which then can get deposited into tissue for example the kidneys.
Antworten
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Type I
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Type II
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Type III
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Type IV
Frage 17
Frage
A bee sting that causes a person to go into anaphylactic shock is an example of this type of hypersensitivity reaction:
Antworten
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Type I
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Type II
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Type III
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Type IV
Frage 18
Frage
The first line of defense which changes very little during our lifetime is called
Antworten
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Passive immunity
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Active immunity
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Adaptive immune response
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Innate immune response
Frage 19
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Humoral immunity is mediated by:
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T lymphocytes (T cells).
-
B lymphocytes (B cells).
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natural killer cells.
-
neutrophils.
Frage 20
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Which white blood cells are responsible for adaptive immunity:
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Monocytes
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Eosinophils
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Neutrophils
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Lymphocytes
Frage 21
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A molecule that will stimulate the adaptive immune response:
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Antigen
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Pathogen
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Immunoglobulin
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Antibody
Frage 22
Frage 23
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The role of memory cells is to:
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change into an antibody-secreting cell following activation.
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immediately secrete antibodies following the first exposure to antigen.
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recognize the antigen and stimulate the immune response.
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bind complement to the antibody.
Frage 24
Frage
Humoral immunity is mediated by:
Antworten
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Natural killer cells
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T cells
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B cells
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Neutrophils
Frage 25
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The most abundant, actively motile, phagocytic leukocyte is the:
Antworten
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Neutrophil
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Monocyte
-
Basophil
-
Macrophage
Frage 26
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Which cells are required to process and present antigens from foreign material as the initial step in the immune response?
Antworten
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T-helper cells
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Macrophages
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Eosinophils
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Monocytes
Frage 27
Frage
The immunoglobulin that is found in tears and saliva is:
Frage 28
Frage
Exposure to peanuts where the person goes into anaphylactic shock is an example of this type of hypersensitivity reaction:
Antworten
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Type III
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Type I
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Type II
-
Type IV
Frage 29
Frage
A common primary target for most immunosuppressant drugs is:
Antworten
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B cell activation
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Macrophages
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All cytokines
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T cell activation
Frage 30
Frage
An autoimmune disease is:
Antworten
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an abnormal response to ingested food and drugs
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failure of the immune system to distinguish self from nonself
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an extreme response to normally harmless material in the environment
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excessive formation of antibodies following exposure to foreign material
Frage 31
Frage
When an allergen binds with IgE antibodies on mast cells, resulting in release of chemical mediators, this reaction is called:
Frage 32
Frage
Autoimmunity arises when a breakdown in 'self-
Antworten
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Specificity
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Immunity
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Memory
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Tolerance
Frage 33
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A 22-year-old prostitute was recently diagnosed with HIV. A decrease in which of the following cell types would be expected to accompany this virus?
Antworten
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CD8 T cells
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T memory cells
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CD4 T cells
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B cells
Frage 34
Frage
Primary immune deficiencies occur because of:
Frage 35
Frage
A 30-year-old male was diagnosed with HIV. Which of the following treatments would be effective?
Frage 36
Frage
Which type of immunity is provided by a vaccination?
Antworten
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Passive natural
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Active artificial
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Active natural
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Passive artificial
Frage 37
Frage
Which of the following is NOT a cause of immunodeficiency?
Antworten
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Hypoplasia of the thymus
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Immunosuppresive agents
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Atrophy of lymph nodes
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Delayed hypersensitivity
Frage 38
Frage
All of the following are factors that promote healing EXCEPT:
Antworten
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Effective circulation
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Advanced age
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Good nutrition: protein, vitamins A & C
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A clean, undisturbed wound
Frage 39
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A raised thickened scar that grows beyond the wound margin is
Antworten
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Keloid scar
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Epithelialisation
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Ulcer
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Hypertrophic scar
Frage 40
Frage
The purpose of inflammation include all the following except:
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Eliminate/neutralise injurious agent
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To remove body toxins
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Localise injury and prevent further damage
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Clean-up tissue for healing
Frage 41
Frage
The first phagocytic cell(s) to enter a site of injury are:
Antworten
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Neutrophils
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Macrophages
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Monocytes
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Lymphocytes
Frage 42
Frage
Systemic manifestations of inflammation include all EXCEPT:
Antworten
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Pyrexia
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Malaise
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Regional swelling
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Anorexia
Frage 43
Frage
Pathophysiology may be defined as the study of:
Frage 44
Frage
Glucocorticoids are produced by
Antworten
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The hypothalamus
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The spleen
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The thymus glands
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The adrenal glands
Frage 45
Frage
The mechanism of action of glucocorticoids include all of the following except:
Antworten
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Inhibit of helper T cells
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Prevent the synthesis of arachidonic acid
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Increase production of antibodies
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Inhibit protein synthesis of chemical mediators
Frage 46
Frage
Which of the following effects is NOT one typically associated with glucocorticoids?
Antworten
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Reduced prostaglandin sythesis
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Stimulation of fat and protein break down
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Reduced bone density
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Increased sodium and water retention
Frage 47
Frage
Patients taking glucocorticoids for long periods of time are likely to develop all of the following
Frage 48
Frage
Which of the following drugs relieves fever and some types of pain but is NOT an anti-inflammatory agent?
Antworten
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Paracetamol
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Prednisone
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Asprin
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Ibuprofen
Frage 49
Frage
Drugs that have anti-inflammatory, analgesic, and antipyretic activities include:
1. COX-2 inhibitors (NSAIDs).
2. glucocorticoids (e.g., prednisone).
3. ibuprofen (NSAID).
4. paracetamol.
5. aspirin.
Frage 50
Frage
All of the following are correct statements regarding wound healing EXCEPT:
Antworten
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Resolution occurs where there is minimal tissue damage and the cells can recover.
-
Regeneration occurs where the cells are capable of mitosis.
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Granulation tissue forms a permanent replacement for damaged tissue.
-
Scar tissue forms where the surrounding cells are incapable of mitosis
Frage 51
Frage
Which of the following factors generally WOULD NOT delay wound healing?
Frage 52
Frage
exudates are thick, yellow/green and typically indicates a bacterial infection
Antworten
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Serous
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Fibrinous
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Purulent
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Haemorrhagic
Frage 53
Frage
Systemic manifestations of inflammation include all EXCEPT:
Antworten
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Pyrexia
-
Malaise
-
Regional swelling
-
Anorexia
Frage 54
Frage
Chemical mediators released during inflammatory response include:
Antworten
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Albumin and fibrinogen
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Growth factors and cell enzymes
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Histamine and prostaglandins
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Macrophages and neutrophils
Frage 55
Frage
Aetiology is defined as the study of the:
Frage 56
Frage
Identify the proper sequence in the healing process
Antworten
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1)A blood clot forms; 2) granulation tissue grows into the gap; 3) new blood vessels develop; 4) phagocytosis of foreign material and cell debris occurs; 5) and collagen fibers form a tight, strong scar.
-
1)Foreign material and cell debris are removed by phagocytes; 2) a blood clot forms; 3) granulation tissue grows into the gap; 4) new blood vessels form; 5) and collagen fibers grow and cross-link.
-
1) A blood clot forms; 2) phagocytes remove foreign material and cell debris; 3) granulation tissue grows into the gap; 4) new blood vessels form; 5) and collagen fibers promote formation of a tight, strong scar.
-
1) Collagen fibers form in the damaged area; 2) a blood clot forms; 3) granulation tissue grows into the gap; 4) angiogenesis takes place; 5) and foreign material and cell debris are removed by phagocytes.
Frage 57
Frage
To which of the following does the term apoptosis refer?
Antworten
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Unplanned death of a group of cells
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Preprogrammed cell self-destruction
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Increase rate of mitosis of cells
-
Necrotic tissue invaded by bacteria
Frage 58
Frage
A patient is on a high dose of glucocorticoids to treat lupus. Which of the following blood tests would a nurse be most concerned about?
Antworten
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Blood glucose
-
Liver enzymes
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Clotting time
-
pH
Frage 59
Frage
A patient with type 1 diabetes was prescribed a glucocorticoid for chronic obstructive pulmonary disease. Which will the nurse expect in the treatment plan?
Antworten
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A decrease in the amount of insulin needed
-
An increase in the amount of insulin needed
-
No change in the amount of insulin needed
-
An increase in the need for carbohydrates
Frage 60
Frage
Inflammation is a non-specific response to:
Frage 61
Frage
Histamines are produced from ? and cause ?.
Antworten
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Plasma proteins; increased platelet aggregation
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Mast cells; vasodilation and increased capillary permeability
-
All cell membranes; pain
-
Platelets; attraction of neurophils
Frage 62
Frage
A broad-spectrum bactericidal agent would be expected to:
Antworten
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reduce the replication of many bacteria.
-
reduce the growth of many gram-positive and gram-negative bacteria
-
destroy many gram-positive and gram-negative bacteria
-
destroy all pathogenic microbes
Frage 63
Frage
Bacterial mutation means that:
Antworten
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pathogens become nonpathogens
-
the host's immune response to that bacteria is strengthened
-
the bacteria survives adverse conditions but can no longer replicate
-
its genetic information has changed
Frage 64
Antworten
-
is the capacity of microbes to cause disease/infection
-
is the size of a specific microbe
-
is the presence of toxins in the blood
-
is the presence of viruses in the blood
Frage 65
Antworten
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are very heat tolerant
-
may cause fever and fatigue
-
can disrupt cellular metabolic and signalling processes causing widespread damage
-
can be incorporated into the structure of the cell membrane as liposaccharides
Frage 66
Frage
Gram negative bacteria have
Antworten
-
A thick peptidoglycan layer cell wall
-
A thin peptidoglycan cell wall sandwiched between an inner cytoplasmic cell membrane and a bacterial outer membrane.
-
No cell wall only a thick cell membrane
-
require oxygen as a source of energy and therefore for growth.
Frage 67
Antworten
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are multicellular organisms
-
have intricate life cycles including egg, larvae and adults stages
-
replicate asexually by cell division
-
all of the answers are correct
Frage 68
Frage
Opportunistic infections are:
Antworten
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An infection by a non-pathogenic organism that has become pathogenic
-
The capacity of microbes to cause disease
-
Presence and multiplication of micro-organisms that is not yet causing disease
-
An organism participating in a symbiotic relationship with the host
Frage 69
Frage
What is a eukaryotic organism, that contains both a cell wall and cell membrane. When they cause an infection it is termed mycosis
Antworten
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Fungi
-
Virus
-
Bacteria
-
Protozoa
Frage 70
Frage
Which of the following factors would NOT increase the virulence of a specific microbe?
Frage 71
Frage
Triazole as an antifungal agent works by:
Antworten
-
Disrupt the synthesis of its cell membrane
-
Disrupt DNA replication
-
Disrupt the synthesis of its cell wall
-
Inhibit hydrogen peroxide metabolism
Frage 72
Frage
An antimicrobial agent with a narrow spectrum of activity reflects a drug that has:
Antworten
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only a weak antibiotic action.
-
effectiveness against a relatively small variety of microbes.
-
a low potency.
-
a narrow margin of safety.
Frage 73
Frage
Which of the following signs would best indicate a bacterial infection (in comparison to a viral infection)?
Antworten
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The presence of pain
-
The presence of purelent exudate.
-
The presence of a serous exudate.
-
The presence of swelling.
Frage 74
Frage
During which period is the infectious disease fully developed?
Antworten
-
Prodromal
-
Acute
-
Incubation
-
Aggresive
Frage 75
Frage
The structure of a virus includes:
Antworten
-
a cell wall and membrane
-
metabolic enzymes and a cell wall
-
a protein coat and either DNA or RNA
-
a slime capsule and cilia
Frage 76
Frage 77
Frage
Bacterial mutation means that:
Antworten
-
pathogens become nonpathogens
-
the bacteria survives adverse conditions but can no longer replicate
-
its genetic information has changed
-
the host's immune response to that bacteria is strengthened
Frage 78
Frage
Which of the following mechanisms is NOT one of the four typical mechanisms of action of antibiotic agents
Antworten
-
Affect bacterial folic acid synthesis
-
Inhibit bacterial DNA synthesis
-
Disrupt bacterial meiosis
-
Disrupt cell wall synthesis
Frage 79
Frage
Which of the following clinical manifestations is not one typically associated with anaphylaxis
Antworten
-
Pruritus
-
Hypertension
-
Stridor
-
Syncopy
Frage 80
Frage
Which of the following is NOT a cause of immunodeficiency?
Antworten
-
Atrophy of lymph nodes
-
Immunosuppresive agents
-
Hypoplasia of the thymus
-
Delayed hypersensitivity
Frage 81
Frage
Primary immune deficiencies occur as a result of:
Antworten
-
A genetic defect affecting immune cell number
-
Human immunodeficiency virus
-
Excessive emotional stress
-
Lack of vitamin C
Frage 82
Frage
An example of a live attenuated vaccine includes:
Frage 83
Frage
The main property of the adaptive immune response for immunity to previously encountered infections is:
Frage 84
Frage
The role of memory cells is to
Antworten
-
change into an antibody-secreting cell following activation.
-
immediately secrete antibodies following the first exposure to antigen.
-
recognize the antigen and stimulate an immune response.
-
activate the hippocampus in the CNS
Frage 85
Frage
White blood cells responsible for adaptive immunity:
Antworten
-
Neutrophils
-
Lymphocytes
-
Monocytes
-
Eosinophils
Frage 86
Frage
Which cells are required to process and present antigens from foreign material as the initial step in the immune response?
Antworten
-
T-helper cells
-
Macrophages
-
Eosinophils
-
Mast cells
Frage 87
Frage
A common primary target for most immunosuppressant drugs is:
Frage 88
Frage
Some common treatments for immunodeficiency may include marrow or thymus transplants and:
Antworten
-
Hyperbaric treatments
-
Blood transfusions and narrow spectrum antibiotics
-
Prophylactic antibiotics and cytokine stimulants
-
Antibiotics and radiation therapy
Frage 89
Frage
Interferons work by:
Antworten
-
Suppress viral replication in infected cells
-
Stimulates cytokine production
-
Inhibit macrophage activity
-
Inducing fever
Frage 90
Frage
The immune system identifies foreign organisms via the recognition of surface:
Antworten
-
antigens
-
cytokines
-
interferons
-
antibodies
Frage 91
Frage
Type 1 diabetes mellitus is associated with a:
Antworten
-
Type III hypersensitivity reaction
-
Type II hypersensitivity reaction
-
Type IV hypersensitivity reaction
-
Type I hypersensitivity reaction
Frage 92
Frage
Systemic lupus erythematosus is caused by:
Antworten
-
development of an immune-deficient state.
-
a chronic allergic condition.
-
immune complex deposits of anti DNA/RNA antibodies.
-
a deficiency of T lymphocytes.
Frage 93
Frage
The type of white blood cells that contains chemical mediators and plays an important part in allergic inflammatory responses is the:
Antworten
-
Basophil
-
Neutrophil
-
Monocyte
-
Macrophage
Frage 94
Frage
The common local effects of an expanding tumour mass include:
1. obstruction of a tube or duct.
2. anemia and weight loss.
3. cell necrosis and ulceration.
4. tumour markers in the circulation.
Frage 95
Frage
Which of the following does paraneoplastic syndrome refer to?
Antworten
-
The decreased resistance to infection resulting from malignant tumors
-
The effects of substances such as hormones secreted by the tumor cells
-
The effects of multiple metastatic tumors
-
Severe weight loss and cachexia associated with advanced cancer
Frage 96
Frage
Ultraviolet light is considered a carcinogen because:
Antworten
-
It produces a carcinogenic enzyme in skin cells
-
It introduces errors into DNA (genes)
-
It directly prevents telomere shortening
-
It directly prevents DNA repair
Frage 97
Frage
First line treatment for testicular cancer always involves
Antworten
-
nodulectomy
-
chemotherapy
-
radiation
-
orchidectomy
Frage 98
Frage
Staging systems used to classify a malignant tumour at the time of diagnosis are based on which of the following factors?
Antworten
-
Size, encapsulated or non-encapsulated, invasion into neighboring tissue
-
Size of the tumour, involvement of lymph nodes, metastases
-
Location of tumour, size, type of cellular abnormality
-
Type of cellular abnormality, size of secondary tumours, location/tissue affected
Frage 99
Frage
Why is a patient with prostate cancer prescribed an estrogen?
Antworten
-
To soften prostatic tissue
-
To decrease the rate of replication for malignant cells
-
To achieve hormonal balance
-
To suppress prostate gland function
Frage 100
Antworten
-
Spread of cancer cells in body cavities/membranes
-
Spread of cancer cells into the nearest lymph node
-
Local spread of cancer cells within a tissue
-
Spread of cancer cells to distant sites in the body by blood or lymph