Imagine that you are talking directly to the person who is farthest away.
Avoid pausing because pauses make you appear unsure.
Use a monotone voice so individuals with limited English proficiency can follow.
Pace of the entire presentation the same, for consistency.
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Frage
In most situations, it is better to use your natural voice rather than a microphone, even if a few people at the back of the room have trouble hearing you.